Changes in retinal vascular bifurcation in eyes with myopia
Abstract Objective To evaluate the effect of myopia on retinal vascular bifurcation. Methods A cross-sectional study that retrospectively analyzed the fundus photographs and clinical data of 493 people who participated in routine physical examinations in Huadong Sanatorium. One eye of each subject w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-10-01
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| Series: | BMC Ophthalmology |
| Online Access: | https://doi.org/10.1186/s12886-022-02629-y |
| _version_ | 1797986060298354688 |
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| author | Caixia Sun Tingli Chen Jing Cong Xinyuan Wu Jing Wang Yuanzhi Yuan |
| author_facet | Caixia Sun Tingli Chen Jing Cong Xinyuan Wu Jing Wang Yuanzhi Yuan |
| author_sort | Caixia Sun |
| collection | DOAJ |
| description | Abstract Objective To evaluate the effect of myopia on retinal vascular bifurcation. Methods A cross-sectional study that retrospectively analyzed the fundus photographs and clinical data of 493 people who participated in routine physical examinations in Huadong Sanatorium. One eye of each subject was included in the analysis. Retinal vascular bifurcation measurements were extracted by using a validated computer program. One-way ANOVA and analysis of covariance were performed to compare the measurements across high myopia, low to moderate myopia, and non-myopia groups. Results The mean age was 41.83 ± 10.43 years and 63.49% were women. The mean spherical equivalent refraction (SER) was − 4.59 ± 3.07 D. Ninety-nine (20.08%) eyes met the definition of high myopia (SER ≤ -6.0 D), along with 234 (47.46%) low to moderate myopia (-6.0 D < SER <-0.5 D), and 160 (32.45%) non-myopia (SER ≥ -0.5 D). The differences in the arteriolar branching angle, venular branching coefficient, venular asymmetry ratio, venular angular asymmetry, and venular junctional exponent among the three groups remained significant (p < 0.05) after multivariate adjustment. Pairwise comparisons showed arteriolar branching angle and venular angular asymmetry in high myopia were significantly lower than low to moderate myopia (p < 0.001, p = 0.014 respectively) and non-myopia (p = 0.007, p = 0.048 respectively). Venular asymmetry ratio and venular branching coefficient in high myopia were significantly higher than low to moderate myopia (p = 0.029, p = 0.001 respectively) and non-myopia (p = 0.041, p = 0.043 respectively). There was a significant difference in venular junctional exponent between high myopia and low to moderate myopia (p = 0.031). Conclusion The vascular bifurcation differs in dependence on the myopic refractive error and a significant increase in the difference can be observed in high myopic eyes. |
| first_indexed | 2024-04-11T07:28:08Z |
| format | Article |
| id | doaj.art-ed334451c69348d79861601d12d13395 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-11T07:28:08Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-ed334451c69348d79861601d12d133952022-12-22T04:37:01ZengBMCBMC Ophthalmology1471-24152022-10-012211810.1186/s12886-022-02629-yChanges in retinal vascular bifurcation in eyes with myopiaCaixia Sun0Tingli Chen1Jing Cong2Xinyuan Wu3Jing Wang4Yuanzhi Yuan5Department of Ophthalmology, Zhongshan Hospital, Fudan UniversityDepartment of Ophthalmology, Huadong SanatoriumDepartment of Ophthalmology, Zhongshan Hospital, Fudan UniversityDepartment of Ophthalmology, Zhongshan Hospital, Fudan UniversityDepartment of Ophthalmology, Huadong SanatoriumDepartment of Ophthalmology, Zhongshan Hospital, Fudan UniversityAbstract Objective To evaluate the effect of myopia on retinal vascular bifurcation. Methods A cross-sectional study that retrospectively analyzed the fundus photographs and clinical data of 493 people who participated in routine physical examinations in Huadong Sanatorium. One eye of each subject was included in the analysis. Retinal vascular bifurcation measurements were extracted by using a validated computer program. One-way ANOVA and analysis of covariance were performed to compare the measurements across high myopia, low to moderate myopia, and non-myopia groups. Results The mean age was 41.83 ± 10.43 years and 63.49% were women. The mean spherical equivalent refraction (SER) was − 4.59 ± 3.07 D. Ninety-nine (20.08%) eyes met the definition of high myopia (SER ≤ -6.0 D), along with 234 (47.46%) low to moderate myopia (-6.0 D < SER <-0.5 D), and 160 (32.45%) non-myopia (SER ≥ -0.5 D). The differences in the arteriolar branching angle, venular branching coefficient, venular asymmetry ratio, venular angular asymmetry, and venular junctional exponent among the three groups remained significant (p < 0.05) after multivariate adjustment. Pairwise comparisons showed arteriolar branching angle and venular angular asymmetry in high myopia were significantly lower than low to moderate myopia (p < 0.001, p = 0.014 respectively) and non-myopia (p = 0.007, p = 0.048 respectively). Venular asymmetry ratio and venular branching coefficient in high myopia were significantly higher than low to moderate myopia (p = 0.029, p = 0.001 respectively) and non-myopia (p = 0.041, p = 0.043 respectively). There was a significant difference in venular junctional exponent between high myopia and low to moderate myopia (p = 0.031). Conclusion The vascular bifurcation differs in dependence on the myopic refractive error and a significant increase in the difference can be observed in high myopic eyes.https://doi.org/10.1186/s12886-022-02629-y |
| spellingShingle | Caixia Sun Tingli Chen Jing Cong Xinyuan Wu Jing Wang Yuanzhi Yuan Changes in retinal vascular bifurcation in eyes with myopia BMC Ophthalmology |
| title | Changes in retinal vascular bifurcation in eyes with myopia |
| title_full | Changes in retinal vascular bifurcation in eyes with myopia |
| title_fullStr | Changes in retinal vascular bifurcation in eyes with myopia |
| title_full_unstemmed | Changes in retinal vascular bifurcation in eyes with myopia |
| title_short | Changes in retinal vascular bifurcation in eyes with myopia |
| title_sort | changes in retinal vascular bifurcation in eyes with myopia |
| url | https://doi.org/10.1186/s12886-022-02629-y |
| work_keys_str_mv | AT caixiasun changesinretinalvascularbifurcationineyeswithmyopia AT tinglichen changesinretinalvascularbifurcationineyeswithmyopia AT jingcong changesinretinalvascularbifurcationineyeswithmyopia AT xinyuanwu changesinretinalvascularbifurcationineyeswithmyopia AT jingwang changesinretinalvascularbifurcationineyeswithmyopia AT yuanzhiyuan changesinretinalvascularbifurcationineyeswithmyopia |