Preparation and Evaluation of Telmisartan Solid Dispersion as Sublingual Tablets
Background: Telmisartan is an antihypertensive angiotensin II receptor antagonist drug commonly used to treat hypertension and renal disease. Based on the Biopharmaceutical Classification System. It’s a Class II poorly soluble drug. Objective: To prepare a sublingual tablet by increasing the dis...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2024-01-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2145 |
| _version_ | 1827391012628070400 |
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| author | Hiba Ayad Aziz Entidhar J. Al-Akkam |
| author_facet | Hiba Ayad Aziz Entidhar J. Al-Akkam |
| author_sort | Hiba Ayad Aziz |
| collection | DOAJ |
| description |
Background: Telmisartan is an antihypertensive angiotensin II receptor antagonist drug commonly used to treat hypertension and renal disease. Based on the Biopharmaceutical Classification System. It’s a Class II poorly soluble drug.
Objective: To prepare a sublingual tablet by increasing the dissolution and solubility of Telmisartan utilizing the solid dispersion method.
Methods: Three methods were obtained to prepare the solid dispersion of telmisartan: solvent evaporation, Kneading, and microwave method. Each method uses surplus as a hydrophilic carrier in different ratios of 1%, 2%, and 3%. Preparation of ternary solid dispersion by adding potassium carbonate salt to the binary solid dispersion. After that preparing the sublingual tablets by applying a direct compression method, using different types and ratios of superdisintegrants such as crospovidone, croscarmellose and sodium starch glycolate in 5% and 10%.
Study the evaluation tests of sublingual tablets, such as friability, hardness, disintegration time and dissolution time.
Results: The solid dispersion showed an improvement in solubility over the pure medication. The best result was obtained with the formula (Telmisartan, soluplus and k2co3 salt at 1:1:0.3 ratio) prepared by microwave method, in this method and the high ratio of soluplus, the solubility increased more than the solvent evaporation and kneading method. The selected tablet is prepared using crospovidone 10% as a superdisintegrant that appears disintegration time in 5 seconds and releases in 1 min in dissolution media.
Conclusion: The solubility and dissolution of Telmisartan were improved by microwave-based ternary solid dispersion using hydrophilic carriers and salt in a ratio of 1:1:0.3 (drug: carrier: salt). The analysis exerts the increases in wettability, enhanced solubility, and dissolution due to conversion from crystal to amorphous state.
Received May. 2023
Accepted Aug. 2023
Published Jan. 2024
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| first_indexed | 2024-03-08T17:02:28Z |
| format | Article |
| id | doaj.art-ed339862915d47b88dc84823152363d0 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:02:28Z |
| publishDate | 2024-01-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-ed339862915d47b88dc84823152363d02024-01-04T08:17:26ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572024-01-0165410.32007/jfacmedbagdad.2145Preparation and Evaluation of Telmisartan Solid Dispersion as Sublingual TabletsHiba Ayad Aziz0Entidhar J. Al-Akkam1pharmacistDepartment of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq Background: Telmisartan is an antihypertensive angiotensin II receptor antagonist drug commonly used to treat hypertension and renal disease. Based on the Biopharmaceutical Classification System. It’s a Class II poorly soluble drug. Objective: To prepare a sublingual tablet by increasing the dissolution and solubility of Telmisartan utilizing the solid dispersion method. Methods: Three methods were obtained to prepare the solid dispersion of telmisartan: solvent evaporation, Kneading, and microwave method. Each method uses surplus as a hydrophilic carrier in different ratios of 1%, 2%, and 3%. Preparation of ternary solid dispersion by adding potassium carbonate salt to the binary solid dispersion. After that preparing the sublingual tablets by applying a direct compression method, using different types and ratios of superdisintegrants such as crospovidone, croscarmellose and sodium starch glycolate in 5% and 10%. Study the evaluation tests of sublingual tablets, such as friability, hardness, disintegration time and dissolution time. Results: The solid dispersion showed an improvement in solubility over the pure medication. The best result was obtained with the formula (Telmisartan, soluplus and k2co3 salt at 1:1:0.3 ratio) prepared by microwave method, in this method and the high ratio of soluplus, the solubility increased more than the solvent evaporation and kneading method. The selected tablet is prepared using crospovidone 10% as a superdisintegrant that appears disintegration time in 5 seconds and releases in 1 min in dissolution media. Conclusion: The solubility and dissolution of Telmisartan were improved by microwave-based ternary solid dispersion using hydrophilic carriers and salt in a ratio of 1:1:0.3 (drug: carrier: salt). The analysis exerts the increases in wettability, enhanced solubility, and dissolution due to conversion from crystal to amorphous state. Received May. 2023 Accepted Aug. 2023 Published Jan. 2024 https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2145Key-word: Potassium carbonate, solid dispersion, soluplus, sublingual tablet, telmisartan. |
| spellingShingle | Hiba Ayad Aziz Entidhar J. Al-Akkam Preparation and Evaluation of Telmisartan Solid Dispersion as Sublingual Tablets مجلة كلية الطب Key-word: Potassium carbonate, solid dispersion, soluplus, sublingual tablet, telmisartan. |
| title | Preparation and Evaluation of Telmisartan Solid Dispersion as Sublingual Tablets |
| title_full | Preparation and Evaluation of Telmisartan Solid Dispersion as Sublingual Tablets |
| title_fullStr | Preparation and Evaluation of Telmisartan Solid Dispersion as Sublingual Tablets |
| title_full_unstemmed | Preparation and Evaluation of Telmisartan Solid Dispersion as Sublingual Tablets |
| title_short | Preparation and Evaluation of Telmisartan Solid Dispersion as Sublingual Tablets |
| title_sort | preparation and evaluation of telmisartan solid dispersion as sublingual tablets |
| topic | Key-word: Potassium carbonate, solid dispersion, soluplus, sublingual tablet, telmisartan. |
| url | https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/2145 |
| work_keys_str_mv | AT hibaayadaziz preparationandevaluationoftelmisartansoliddispersionassublingualtablets AT entidharjalakkam preparationandevaluationoftelmisartansoliddispersionassublingualtablets |