Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion.
The exocyst complex subunit Sec5 is a downstream effector of RalA-GTPase which promotes RalA-exocyst interactions and exocyst assembly, serving to tether secretory granules to docking sites on the plasma membrane. We recently reported that RalA regulates biphasic insulin secretion in pancreatic isle...
Main Authors: | Li Xie, Dan Zhu, Youhou Kang, Tao Liang, Yu He, Herbert Y Gaisano |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3699660?pdf=render |
Similar Items
-
Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis
by: Fei Kang, et al.
Published: (2022-10-01) -
Regulation of insulin granule exocytosis
by: Renström, E, et al.
Published: (2008) -
Regulated exocytosis of single insulin granules and synaptic-like vesicles in membrane patches of insulin secreting cells
by: Macdonald, P, et al.
Published: (2004) -
Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells.
by: Olofsson, C, et al.
Published: (2002) -
The Cell Physiology of Biphasic Insulin Secretion.
by: Rorsman, P, et al.
Published: (2000)