Biosensors to Diagnose Chagas Disease: A Brief Review
Chagas disease (CD), which mostly affects those living in deprived areas, has become one of Latin America’s main public health problems. Effective prevention of the disease requires early diagnosis, initiation of therapy, and regular blood monitoring of the infected individual. However, the majority...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-11-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/17/11/2629 |
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| author | María-Isabel Rocha-Gaso Luis-Jesús Villarreal-Gómez Denis Beyssen Frédéric Sarry Marco-Antonio Reyna Carlos-Napoleón Ibarra-Cerdeña |
| author_facet | María-Isabel Rocha-Gaso Luis-Jesús Villarreal-Gómez Denis Beyssen Frédéric Sarry Marco-Antonio Reyna Carlos-Napoleón Ibarra-Cerdeña |
| author_sort | María-Isabel Rocha-Gaso |
| collection | DOAJ |
| description | Chagas disease (CD), which mostly affects those living in deprived areas, has become one of Latin America’s main public health problems. Effective prevention of the disease requires early diagnosis, initiation of therapy, and regular blood monitoring of the infected individual. However, the majority of the Trypanosoma cruzi infections go undiagnosed because of mild symptoms, limited access to medical attention and to a high variability in the sensitivity and specificity of diagnostic tests. Consequently, more affordable and accessible detection technologies capable of providing early diagnosis and T. cruzi load measurements in settings where CD is most prevalent are needed to enable enhanced intervention strategies. This work analyzes the potential contribution of biosensing technologies, reviewing examples that have been tested and contrasted with traditional methods, both serological and parasitological (i.e., molecular detection by PCR), and discusses some emerging biosensing technologies that have been applied for this public health issue. Even if biosensing technologies still require further research efforts to develop portable systems, we arrive at the conclusion that biosensors could improve the accuracy of CD diagnosis and the follow-up of patients’ treatments in terms of the rapidity of results, small sample volume, high integration, ease of use, real-time and low cost detection when compared with current conventional technologies. |
| first_indexed | 2024-04-14T00:40:59Z |
| format | Article |
| id | doaj.art-ed369c59e2674e0093be45520de471ca |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-14T00:40:59Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-ed369c59e2674e0093be45520de471ca2022-12-22T02:22:12ZengMDPI AGSensors1424-82202017-11-011711262910.3390/s17112629s17112629Biosensors to Diagnose Chagas Disease: A Brief ReviewMaría-Isabel Rocha-Gaso0Luis-Jesús Villarreal-Gómez1Denis Beyssen2Frédéric Sarry3Marco-Antonio Reyna4Carlos-Napoleón Ibarra-Cerdeña5Departamento de Ciencias Computacionales, Universidad de Quintana Roo, Unidad Cancún, 77519 Cancún, MexicoEscuela de Ciencias de la Ingeniería y Tecnología, Cuerpo Académico de Bioingeniería y Salud Ambiental, Universidad Autónoma de Baja California, 22260 Tijuana, MexicoInstitut Jean Lamour, 54600 Villers-lès-Nancy, FranceInstitut Jean Lamour, 54600 Villers-lès-Nancy, FranceEscuela de Ciencias de la Ingeniería y Tecnología, Cuerpo Académico de Bioingeniería y Salud Ambiental, Universidad Autónoma de Baja California, 22260 Tijuana, MexicoDepartamento de Ecología Humana, Cinvestav Unidad Mérida, 97310 Mérida, MexicoChagas disease (CD), which mostly affects those living in deprived areas, has become one of Latin America’s main public health problems. Effective prevention of the disease requires early diagnosis, initiation of therapy, and regular blood monitoring of the infected individual. However, the majority of the Trypanosoma cruzi infections go undiagnosed because of mild symptoms, limited access to medical attention and to a high variability in the sensitivity and specificity of diagnostic tests. Consequently, more affordable and accessible detection technologies capable of providing early diagnosis and T. cruzi load measurements in settings where CD is most prevalent are needed to enable enhanced intervention strategies. This work analyzes the potential contribution of biosensing technologies, reviewing examples that have been tested and contrasted with traditional methods, both serological and parasitological (i.e., molecular detection by PCR), and discusses some emerging biosensing technologies that have been applied for this public health issue. Even if biosensing technologies still require further research efforts to develop portable systems, we arrive at the conclusion that biosensors could improve the accuracy of CD diagnosis and the follow-up of patients’ treatments in terms of the rapidity of results, small sample volume, high integration, ease of use, real-time and low cost detection when compared with current conventional technologies.https://www.mdpi.com/1424-8220/17/11/2629Chagas diseasebiosensorsdetection technologiesdiagnosis |
| spellingShingle | María-Isabel Rocha-Gaso Luis-Jesús Villarreal-Gómez Denis Beyssen Frédéric Sarry Marco-Antonio Reyna Carlos-Napoleón Ibarra-Cerdeña Biosensors to Diagnose Chagas Disease: A Brief Review Sensors Chagas disease biosensors detection technologies diagnosis |
| title | Biosensors to Diagnose Chagas Disease: A Brief Review |
| title_full | Biosensors to Diagnose Chagas Disease: A Brief Review |
| title_fullStr | Biosensors to Diagnose Chagas Disease: A Brief Review |
| title_full_unstemmed | Biosensors to Diagnose Chagas Disease: A Brief Review |
| title_short | Biosensors to Diagnose Chagas Disease: A Brief Review |
| title_sort | biosensors to diagnose chagas disease a brief review |
| topic | Chagas disease biosensors detection technologies diagnosis |
| url | https://www.mdpi.com/1424-8220/17/11/2629 |
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