Canine serological survey and dog culling ant its relationship with human visceral leishmaniasis in an endemic urban area
Abstract Background Visceral leishmaniasis is an important but neglected disease that is spreading and is highly lethal when left untreated. This study sought to measure the Leishmania infantum seroprevalence in dogs, the coverage of its control activities (identification of the canine reservoir by...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-020-05125-0 |
| _version_ | 1819063044498522112 |
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| author | Patricia Marques Moralejo Bermudi Danielle Nunes Carneiro Castro Costa Caris Maroni Nunes Jose Eduardo Tolezano Roberto Mitsuyoshi Hiramoto Lilian Aparecida Colebrusco Rodas Rafael Silva Cipriano Marta Blangiardo Francisco Chiaravalloti-Neto |
| author_facet | Patricia Marques Moralejo Bermudi Danielle Nunes Carneiro Castro Costa Caris Maroni Nunes Jose Eduardo Tolezano Roberto Mitsuyoshi Hiramoto Lilian Aparecida Colebrusco Rodas Rafael Silva Cipriano Marta Blangiardo Francisco Chiaravalloti-Neto |
| author_sort | Patricia Marques Moralejo Bermudi |
| collection | DOAJ |
| description | Abstract Background Visceral leishmaniasis is an important but neglected disease that is spreading and is highly lethal when left untreated. This study sought to measure the Leishmania infantum seroprevalence in dogs, the coverage of its control activities (identification of the canine reservoir by serological survey, dog culling and insecticide spraying) and to evaluate its relationship with the occurrence of the disease in humans in the municipalities of Araçatuba and Birigui, state of São Paulo, Brazil. Methods Information from 2006 to 2015 was georeferenced for each municipality and modeling was performed for the two municipalities together. To do this, latent Gaussian Bayesian models with the incorporation of a spatio-temporal structure and Poisson distribution were used. The Besag-York-Mollie models were applied for random spatial effects, as also were autoregressive models of order 1 for random temporal effects. The modeling was performed using the INLA (Integrated Nested Laplace Approximations) deterministic approach, considering both the numbers of cases as well as the coverage paired year by year and lagged at one and two years. Results Control activity coverage was observed to be generally low. The behavior of the temporal tendency in the human disease presented distinct patterns in the two municipalities, however, in both the tendency was to decline. The canine serological survey presented as a protective factor only in the two-year lag model. Conclusions The canine serological coverage, even at low intensity, carried out jointly with the culling of the positive dogs, suggested a decreasing effect on the occurrence of the disease in humans, whose effects would be seen two years after it was carried out. |
| first_indexed | 2024-12-21T15:08:25Z |
| format | Article |
| id | doaj.art-ed37400912954f6fbc7cd6297f73b83a |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-21T15:08:25Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-ed37400912954f6fbc7cd6297f73b83a2022-12-21T18:59:21ZengBMCBMC Infectious Diseases1471-23342020-06-0120111110.1186/s12879-020-05125-0Canine serological survey and dog culling ant its relationship with human visceral leishmaniasis in an endemic urban areaPatricia Marques Moralejo Bermudi0Danielle Nunes Carneiro Castro Costa1Caris Maroni Nunes2Jose Eduardo Tolezano3Roberto Mitsuyoshi Hiramoto4Lilian Aparecida Colebrusco Rodas5Rafael Silva Cipriano6Marta Blangiardo7Francisco Chiaravalloti-Neto8Department of Epidemiology, School of Public Health, Universidade de São Paulo (USP)Department of Epidemiology, School of Public Health, Universidade de São Paulo (USP)Department of Animal Health and Production, School of Veterinary Medicine, UnespCenter for Parasitology and Mycology, Instituto Adolfo LutzCenter for Parasitology and Mycology, Instituto Adolfo LutzRegional Service 9, Superintendência de Controle de EndemiasZoonosis Control CenterMRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial CollegeDepartment of Epidemiology, School of Public Health, Universidade de São Paulo (USP)Abstract Background Visceral leishmaniasis is an important but neglected disease that is spreading and is highly lethal when left untreated. This study sought to measure the Leishmania infantum seroprevalence in dogs, the coverage of its control activities (identification of the canine reservoir by serological survey, dog culling and insecticide spraying) and to evaluate its relationship with the occurrence of the disease in humans in the municipalities of Araçatuba and Birigui, state of São Paulo, Brazil. Methods Information from 2006 to 2015 was georeferenced for each municipality and modeling was performed for the two municipalities together. To do this, latent Gaussian Bayesian models with the incorporation of a spatio-temporal structure and Poisson distribution were used. The Besag-York-Mollie models were applied for random spatial effects, as also were autoregressive models of order 1 for random temporal effects. The modeling was performed using the INLA (Integrated Nested Laplace Approximations) deterministic approach, considering both the numbers of cases as well as the coverage paired year by year and lagged at one and two years. Results Control activity coverage was observed to be generally low. The behavior of the temporal tendency in the human disease presented distinct patterns in the two municipalities, however, in both the tendency was to decline. The canine serological survey presented as a protective factor only in the two-year lag model. Conclusions The canine serological coverage, even at low intensity, carried out jointly with the culling of the positive dogs, suggested a decreasing effect on the occurrence of the disease in humans, whose effects would be seen two years after it was carried out.http://link.springer.com/article/10.1186/s12879-020-05125-0Visceral leishmaniasisEcological studyControl measuresBrazil |
| spellingShingle | Patricia Marques Moralejo Bermudi Danielle Nunes Carneiro Castro Costa Caris Maroni Nunes Jose Eduardo Tolezano Roberto Mitsuyoshi Hiramoto Lilian Aparecida Colebrusco Rodas Rafael Silva Cipriano Marta Blangiardo Francisco Chiaravalloti-Neto Canine serological survey and dog culling ant its relationship with human visceral leishmaniasis in an endemic urban area BMC Infectious Diseases Visceral leishmaniasis Ecological study Control measures Brazil |
| title | Canine serological survey and dog culling ant its relationship with human visceral leishmaniasis in an endemic urban area |
| title_full | Canine serological survey and dog culling ant its relationship with human visceral leishmaniasis in an endemic urban area |
| title_fullStr | Canine serological survey and dog culling ant its relationship with human visceral leishmaniasis in an endemic urban area |
| title_full_unstemmed | Canine serological survey and dog culling ant its relationship with human visceral leishmaniasis in an endemic urban area |
| title_short | Canine serological survey and dog culling ant its relationship with human visceral leishmaniasis in an endemic urban area |
| title_sort | canine serological survey and dog culling ant its relationship with human visceral leishmaniasis in an endemic urban area |
| topic | Visceral leishmaniasis Ecological study Control measures Brazil |
| url | http://link.springer.com/article/10.1186/s12879-020-05125-0 |
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