Disrupted Topological Organization of Functional Networks in Asymptomatic Carotid Plaque Without Significant Carotid Stenosis: A Resting-State fMRI Study
Purpose: Previous studies have found that there are significant changes in functional network properties for patients with moderate to severe carotid artery stenosis. Our study aimed to explore the topology properties of brain functional network in asymptomatic patients with carotid plaque without s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2021.685763/full |
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| author | Jia Tuo Jia Tuo Jia Tuo Wei He Wei He Wei He Shuai Yang Shuai Yang Lihui Liu Lihui Liu Lihui Liu Xiaojuan Liu Xiaojuan Liu Xiaojuan Liu Hui Liu Hui Liu Yang Wang Yang Wang Yang Wang Tao Tang Tao Tang Tao Tang Jian Xia Jian Xia Jian Xia Weihua Liao Weihua Liao Weihua Liao Yunhai Liu Yunhai Liu Yunhai Liu Qing Huang Qing Huang Qing Huang |
| author_facet | Jia Tuo Jia Tuo Jia Tuo Wei He Wei He Wei He Shuai Yang Shuai Yang Lihui Liu Lihui Liu Lihui Liu Xiaojuan Liu Xiaojuan Liu Xiaojuan Liu Hui Liu Hui Liu Yang Wang Yang Wang Yang Wang Tao Tang Tao Tang Tao Tang Jian Xia Jian Xia Jian Xia Weihua Liao Weihua Liao Weihua Liao Yunhai Liu Yunhai Liu Yunhai Liu Qing Huang Qing Huang Qing Huang |
| author_sort | Jia Tuo |
| collection | DOAJ |
| description | Purpose: Previous studies have found that there are significant changes in functional network properties for patients with moderate to severe carotid artery stenosis. Our study aimed to explore the topology properties of brain functional network in asymptomatic patients with carotid plaque without significant stenosis.Methods: A total of 61 asymptomatic patients with carotid plaque (mean age 61.79 ± 7.35 years) and 25 healthy control subjects (HC; 58.12 ± 6.79 years) were recruited. General data collection, carotid ultrasound examination and resting state functional magnetic resonance imaging were performed on all subjects. Graph-theory was applied to examine the differences in the brain functional network topological properties between two groups.Results: In the plaque group, Eloc(P = 0.03), γ (P = 0.01), and σ (P = 0.01) were significantly higher than in the HC group. The degree centrality of left middle frontal gyrus and the nodal efficiency of left middle frontal gyrus and right inferior parietal angular gyrus were significantly higher in the plaque group than in HC. The degree centrality and betweenness centrality of right middle temporal gyrus, as well as the nodal efficiency of right middle temporal gyrus, were significantly lower in the plaque group than in HC.Conclusions: The brain functional networks of patients with carotid plaques differ from those of healthy controls. Asymptomatic patients with carotid plaques exhibit increased local and global connectivity, which may reflect subtle reorganizations in response to early brain damage. |
| first_indexed | 2024-12-17T22:57:38Z |
| format | Article |
| id | doaj.art-ed37d92ec55e4b57ad0e0362801e8be6 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-17T22:57:38Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-ed37d92ec55e4b57ad0e0362801e8be62022-12-21T21:29:31ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612021-08-011510.3389/fnhum.2021.685763685763Disrupted Topological Organization of Functional Networks in Asymptomatic Carotid Plaque Without Significant Carotid Stenosis: A Resting-State fMRI StudyJia Tuo0Jia Tuo1Jia Tuo2Wei He3Wei He4Wei He5Shuai Yang6Shuai Yang7Lihui Liu8Lihui Liu9Lihui Liu10Xiaojuan Liu11Xiaojuan Liu12Xiaojuan Liu13Hui Liu14Hui Liu15Yang Wang16Yang Wang17Yang Wang18Tao Tang19Tao Tang20Tao Tang21Jian Xia22Jian Xia23Jian Xia24Weihua Liao25Weihua Liao26Weihua Liao27Yunhai Liu28Yunhai Liu29Yunhai Liu30Qing Huang31Qing Huang32Qing Huang33Department of Neurology, Chenzhou No.1 People's Hospital, Chenzhou, ChinaHunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaHunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Emergency, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Integrated Traditional and Western, Xiangya Hospital, Central South University, Changsha, ChinaHunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Integrated Traditional and Western, Xiangya Hospital, Central South University, Changsha, ChinaHunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaHunan Clinical Research Center for Cerebrovascular Disease, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaPurpose: Previous studies have found that there are significant changes in functional network properties for patients with moderate to severe carotid artery stenosis. Our study aimed to explore the topology properties of brain functional network in asymptomatic patients with carotid plaque without significant stenosis.Methods: A total of 61 asymptomatic patients with carotid plaque (mean age 61.79 ± 7.35 years) and 25 healthy control subjects (HC; 58.12 ± 6.79 years) were recruited. General data collection, carotid ultrasound examination and resting state functional magnetic resonance imaging were performed on all subjects. Graph-theory was applied to examine the differences in the brain functional network topological properties between two groups.Results: In the plaque group, Eloc(P = 0.03), γ (P = 0.01), and σ (P = 0.01) were significantly higher than in the HC group. The degree centrality of left middle frontal gyrus and the nodal efficiency of left middle frontal gyrus and right inferior parietal angular gyrus were significantly higher in the plaque group than in HC. The degree centrality and betweenness centrality of right middle temporal gyrus, as well as the nodal efficiency of right middle temporal gyrus, were significantly lower in the plaque group than in HC.Conclusions: The brain functional networks of patients with carotid plaques differ from those of healthy controls. Asymptomatic patients with carotid plaques exhibit increased local and global connectivity, which may reflect subtle reorganizations in response to early brain damage.https://www.frontiersin.org/articles/10.3389/fnhum.2021.685763/fullfunctional networkstopological organizationcarotid plaquestrokeresting-state fMRI |
| spellingShingle | Jia Tuo Jia Tuo Jia Tuo Wei He Wei He Wei He Shuai Yang Shuai Yang Lihui Liu Lihui Liu Lihui Liu Xiaojuan Liu Xiaojuan Liu Xiaojuan Liu Hui Liu Hui Liu Yang Wang Yang Wang Yang Wang Tao Tang Tao Tang Tao Tang Jian Xia Jian Xia Jian Xia Weihua Liao Weihua Liao Weihua Liao Yunhai Liu Yunhai Liu Yunhai Liu Qing Huang Qing Huang Qing Huang Disrupted Topological Organization of Functional Networks in Asymptomatic Carotid Plaque Without Significant Carotid Stenosis: A Resting-State fMRI Study Frontiers in Human Neuroscience functional networks topological organization carotid plaque stroke resting-state fMRI |
| title | Disrupted Topological Organization of Functional Networks in Asymptomatic Carotid Plaque Without Significant Carotid Stenosis: A Resting-State fMRI Study |
| title_full | Disrupted Topological Organization of Functional Networks in Asymptomatic Carotid Plaque Without Significant Carotid Stenosis: A Resting-State fMRI Study |
| title_fullStr | Disrupted Topological Organization of Functional Networks in Asymptomatic Carotid Plaque Without Significant Carotid Stenosis: A Resting-State fMRI Study |
| title_full_unstemmed | Disrupted Topological Organization of Functional Networks in Asymptomatic Carotid Plaque Without Significant Carotid Stenosis: A Resting-State fMRI Study |
| title_short | Disrupted Topological Organization of Functional Networks in Asymptomatic Carotid Plaque Without Significant Carotid Stenosis: A Resting-State fMRI Study |
| title_sort | disrupted topological organization of functional networks in asymptomatic carotid plaque without significant carotid stenosis a resting state fmri study |
| topic | functional networks topological organization carotid plaque stroke resting-state fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2021.685763/full |
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