DNA methylation evidence against the accelerated aging hypothesis of schizophrenia
Abstract The accelerated aging hypothesis of schizophrenia posits that physiological changes throughout the body that are associated with normal aging occur at an earlier age in individuals with schizophrenia. Testing this hypothesis has been limited by problems measuring biological age. Recently, a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-03-01
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| Series: | npj Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-017-0017-5 |
| _version_ | 1797428767700811776 |
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| author | Brandon C. McKinney Huang Lin Ying Ding David A. Lewis Robert A. Sweet |
| author_facet | Brandon C. McKinney Huang Lin Ying Ding David A. Lewis Robert A. Sweet |
| author_sort | Brandon C. McKinney |
| collection | DOAJ |
| description | Abstract The accelerated aging hypothesis of schizophrenia posits that physiological changes throughout the body that are associated with normal aging occur at an earlier age in individuals with schizophrenia. Testing this hypothesis has been limited by problems measuring biological age. Recently, a method using DNA methylation levels at 353 genomic sites to produce “DNA methylation age”, an estimate of tissue biological age, was described and validated. We used this method to test the hypothesis in the postmortem superior temporal gyrus of 22 non-psychiatric control and 22 schizophrenia subjects. DNA methylation age correlated with chronological age in both non-psychiatric control (r = 0.95, p < 0.0001) and schizophrenia subjects (r = 0.96, p < 0.0001). Age acceleration did not differ between non-psychiatric control and schizophrenia subjects (t = 1.27, p = 0.21). Our findings suggest there is no acceleration of brain aging in schizophrenia. Larger studies using samples from multiple brain regions and homogenous cell populations will be necessary to confirm these findings. |
| first_indexed | 2024-03-09T09:02:40Z |
| format | Article |
| id | doaj.art-ed396e9f81fe4ef7a7fac2ba0ce6e291 |
| institution | Directory Open Access Journal |
| issn | 2334-265X |
| language | English |
| last_indexed | 2024-03-09T09:02:40Z |
| publishDate | 2017-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Schizophrenia |
| spelling | doaj.art-ed396e9f81fe4ef7a7fac2ba0ce6e2912023-12-02T11:15:05ZengNature Portfolionpj Schizophrenia2334-265X2017-03-01311310.1038/s41537-017-0017-5DNA methylation evidence against the accelerated aging hypothesis of schizophreniaBrandon C. McKinney0Huang Lin1Ying Ding2David A. Lewis3Robert A. Sweet4Departments of Psychiatry, University of PittsburghDepartments of Biostatistics, University of PittsburghDepartments of Biostatistics, University of PittsburghDepartments of Psychiatry, University of PittsburghDepartments of Psychiatry, University of PittsburghAbstract The accelerated aging hypothesis of schizophrenia posits that physiological changes throughout the body that are associated with normal aging occur at an earlier age in individuals with schizophrenia. Testing this hypothesis has been limited by problems measuring biological age. Recently, a method using DNA methylation levels at 353 genomic sites to produce “DNA methylation age”, an estimate of tissue biological age, was described and validated. We used this method to test the hypothesis in the postmortem superior temporal gyrus of 22 non-psychiatric control and 22 schizophrenia subjects. DNA methylation age correlated with chronological age in both non-psychiatric control (r = 0.95, p < 0.0001) and schizophrenia subjects (r = 0.96, p < 0.0001). Age acceleration did not differ between non-psychiatric control and schizophrenia subjects (t = 1.27, p = 0.21). Our findings suggest there is no acceleration of brain aging in schizophrenia. Larger studies using samples from multiple brain regions and homogenous cell populations will be necessary to confirm these findings.https://doi.org/10.1038/s41537-017-0017-5 |
| spellingShingle | Brandon C. McKinney Huang Lin Ying Ding David A. Lewis Robert A. Sweet DNA methylation evidence against the accelerated aging hypothesis of schizophrenia npj Schizophrenia |
| title | DNA methylation evidence against the accelerated aging hypothesis of schizophrenia |
| title_full | DNA methylation evidence against the accelerated aging hypothesis of schizophrenia |
| title_fullStr | DNA methylation evidence against the accelerated aging hypothesis of schizophrenia |
| title_full_unstemmed | DNA methylation evidence against the accelerated aging hypothesis of schizophrenia |
| title_short | DNA methylation evidence against the accelerated aging hypothesis of schizophrenia |
| title_sort | dna methylation evidence against the accelerated aging hypothesis of schizophrenia |
| url | https://doi.org/10.1038/s41537-017-0017-5 |
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