A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population
Narumi Muto, 1,* Kentaro Oniki, 1,* Miku Kudo, 1 Yui Obata, 1 Yuki Sakamoto, 1 Naoto Tokumaru, 1 Tomoko Izuka, 1 Takehisa Watanabe, 2 Koji Otake, 3 Yasuhiro Ogata, 3 Junji Saruwatari 1 1Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumam...
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| Format: | Article |
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Dove Medical Press
2020-02-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/a-pilot-study-assessing-the-possible-combined-effect-of-physical-activ-peer-reviewed-article-DMSO |
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| author | Muto N Oniki K Kudo M Obata Y Sakamoto Y Tokumaru N Izuka T Watanabe T Otake K Ogata Y Saruwatari J |
| author_facet | Muto N Oniki K Kudo M Obata Y Sakamoto Y Tokumaru N Izuka T Watanabe T Otake K Ogata Y Saruwatari J |
| author_sort | Muto N |
| collection | DOAJ |
| description | Narumi Muto, 1,* Kentaro Oniki, 1,* Miku Kudo, 1 Yui Obata, 1 Yuki Sakamoto, 1 Naoto Tokumaru, 1 Tomoko Izuka, 1 Takehisa Watanabe, 2 Koji Otake, 3 Yasuhiro Ogata, 3 Junji Saruwatari 1 1Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; 2Departments of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan; 3Japanese Red Cross Kumamoto Health Care Center, Kumamoto, Japan*These authors contributed equally to this workCorrespondence: Junji SaruwatariDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, JapanTel/Fax +81 96-371-4512Email junsaru@gpo.kumamoto-u.ac.jpPurpose: The patatin-like phospholipase domain containing protein 3 (PNPLA3) rs738409 polymorphism (c.444C>G) is the most well-known genetic risk factor for non-alcoholic fatty liver disease (NAFLD), but whether or not physical activity influences the association between the PNPLA3 genotype and risk of NAFLD is unclear.Patients and Methods: A retrospective longitudinal analysis was conducted among 352 Japanese subjects. Each type of physical activity was assigned a metabolic equivalent (MET), and the subjects were classified into sedentary, low or high groups using the “METS*T” (METs × hours per week) value of 5 or 21 as a threshold.Results: Among the PNPLA3 G/G genotype carriers, the high and low METS*T groups had a lower risk of NAFLD than the sedentary METS*T group (odds ratio [95% confidence interval]: 0.14 [0.02– 0.99] and 0.16 [0.03– 1.04], respectively). Furthermore, the PNPLA3 C/C or C/G genotype carriers showed no significant difference in the risk of NAFLD among the three METS*T groups.Conclusion: The PNPLA3 rs738409 genotype may be associated with the beneficial effects of physical activity on the risk of NAFLD among elderly Japanese individuals. Further comprehensive investigations are therefore needed to verify the preliminary results.Keywords: weight status, liver steatosis, patatin-like phospholipase domain containing protein 3, genetic polymorphism |
| first_indexed | 2024-04-10T18:14:13Z |
| format | Article |
| id | doaj.art-ed3d22588c3d461da248fab810327511 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:14:13Z |
| publishDate | 2020-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-ed3d22588c3d461da248fab8103275112023-02-02T10:11:41ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072020-02-01Volume 1333334151746A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General PopulationMuto NOniki KKudo MObata YSakamoto YTokumaru NIzuka TWatanabe TOtake KOgata YSaruwatari JNarumi Muto, 1,* Kentaro Oniki, 1,* Miku Kudo, 1 Yui Obata, 1 Yuki Sakamoto, 1 Naoto Tokumaru, 1 Tomoko Izuka, 1 Takehisa Watanabe, 2 Koji Otake, 3 Yasuhiro Ogata, 3 Junji Saruwatari 1 1Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; 2Departments of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan; 3Japanese Red Cross Kumamoto Health Care Center, Kumamoto, Japan*These authors contributed equally to this workCorrespondence: Junji SaruwatariDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, JapanTel/Fax +81 96-371-4512Email junsaru@gpo.kumamoto-u.ac.jpPurpose: The patatin-like phospholipase domain containing protein 3 (PNPLA3) rs738409 polymorphism (c.444C>G) is the most well-known genetic risk factor for non-alcoholic fatty liver disease (NAFLD), but whether or not physical activity influences the association between the PNPLA3 genotype and risk of NAFLD is unclear.Patients and Methods: A retrospective longitudinal analysis was conducted among 352 Japanese subjects. Each type of physical activity was assigned a metabolic equivalent (MET), and the subjects were classified into sedentary, low or high groups using the “METS*T” (METs × hours per week) value of 5 or 21 as a threshold.Results: Among the PNPLA3 G/G genotype carriers, the high and low METS*T groups had a lower risk of NAFLD than the sedentary METS*T group (odds ratio [95% confidence interval]: 0.14 [0.02– 0.99] and 0.16 [0.03– 1.04], respectively). Furthermore, the PNPLA3 C/C or C/G genotype carriers showed no significant difference in the risk of NAFLD among the three METS*T groups.Conclusion: The PNPLA3 rs738409 genotype may be associated with the beneficial effects of physical activity on the risk of NAFLD among elderly Japanese individuals. Further comprehensive investigations are therefore needed to verify the preliminary results.Keywords: weight status, liver steatosis, patatin-like phospholipase domain containing protein 3, genetic polymorphismhttps://www.dovepress.com/a-pilot-study-assessing-the-possible-combined-effect-of-physical-activ-peer-reviewed-article-DMSOweight statusliver steatosispatatin-like phospholipase domain containing protein 3genetic polymorphism |
| spellingShingle | Muto N Oniki K Kudo M Obata Y Sakamoto Y Tokumaru N Izuka T Watanabe T Otake K Ogata Y Saruwatari J A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population Diabetes, Metabolic Syndrome and Obesity weight status liver steatosis patatin-like phospholipase domain containing protein 3 genetic polymorphism |
| title | A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population |
| title_full | A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population |
| title_fullStr | A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population |
| title_full_unstemmed | A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population |
| title_short | A Pilot Study Assessing the Possible Combined Effect of Physical Activity and PNPLA3 rs738409 Polymorphism on the Risk for Non-Alcoholic Fatty Liver Disease in the Japanese Elderly General Population |
| title_sort | pilot study assessing the possible combined effect of physical activity and pnpla3 rs738409 polymorphism on the risk for non alcoholic fatty liver disease in the japanese elderly general population |
| topic | weight status liver steatosis patatin-like phospholipase domain containing protein 3 genetic polymorphism |
| url | https://www.dovepress.com/a-pilot-study-assessing-the-possible-combined-effect-of-physical-activ-peer-reviewed-article-DMSO |
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