Assessment of salivary alpha amylase and mucin-4 before and after non-surgical treatment of peri-implant mucositis
Abstract Background The present study was based on the null hypothesis that there is no difference in clinicoradiographic parameters and whole salivary alpha amylase (AA) and mucin-4 levels before and after non-surgical mechanical debridement (NSMD) of patients with peri-implant mucositis (PM). The...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-07-01
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| Series: | International Journal of Implant Dentistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40729-022-00429-z |
| _version_ | 1811293855201361920 |
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| author | Hajer A. Aldulaijan Abeer S. Al-Zawawi Marwa Y. Shaheen Dena Ali Darshan Devang Divakar Amani M. Basudan |
| author_facet | Hajer A. Aldulaijan Abeer S. Al-Zawawi Marwa Y. Shaheen Dena Ali Darshan Devang Divakar Amani M. Basudan |
| author_sort | Hajer A. Aldulaijan |
| collection | DOAJ |
| description | Abstract Background The present study was based on the null hypothesis that there is no difference in clinicoradiographic parameters and whole salivary alpha amylase (AA) and mucin-4 levels before and after non-surgical mechanical debridement (NSMD) of patients with peri-implant mucositis (PM). The aim was to assess whole salivary AA and mucin-4 levels before and after treatment of PM. Methods Patients with PM (Group-1) and individuals without peri-implant diseases (Group-2) were included. Demographic data was collected and peri-implant modified plaque and bleeding indices (mPI and mBI, respectively), probing depth (PD) and crestal bone loss were measured at baseline. Levels of AA and mucin-4 were assessed in unstimulated whole saliva samples. All patients underwent full-mouth non-surgical periodontal therapy (NSPT) and NSMD; and clinical parameters and salivary biomarkers were re-assessed after 3 months. Level of significance was set at P < 0.01. Results Twenty-six and 32 individuals were included in groups 1 and 2, respectively. None of the participants had periodontitis. At baseline clinical periodontal parameters (PI [P < 0.001], GI [P < 0.001], clinical AL [P < 0.001] and PD [P < 0.001]) were significantly high in Group-1 than Group-2. At 3-month follow-up, there was a statistically significant reduction in clinical periodontal and peri-implant parameters (PI [P < 0.01], GI [P < 0.01], and PD [P < 0.01]) in Group-1 compared with their baseline values. At baseline, salivary AA levels were significantly high in Group-1 than Group-2 (P < 0.01). At 3-month follow-up, there was no significant difference in whole salivary AA levels among patients in groups 1 and 2. Conclusions The AA and mucin-4 levels are potential biomarkers for evaluation of peri-implant diseases including PM. Mechanical instrumentation continues to be the most predictable treatment option for the management of peri-implant diseases. |
| first_indexed | 2024-04-13T05:07:44Z |
| format | Article |
| id | doaj.art-ed3d962d4ca54763b94a7fd306b7ba0b |
| institution | Directory Open Access Journal |
| issn | 2198-4034 |
| language | English |
| last_indexed | 2024-04-13T05:07:44Z |
| publishDate | 2022-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | International Journal of Implant Dentistry |
| spelling | doaj.art-ed3d962d4ca54763b94a7fd306b7ba0b2022-12-22T03:01:08ZengSpringerOpenInternational Journal of Implant Dentistry2198-40342022-07-01811910.1186/s40729-022-00429-zAssessment of salivary alpha amylase and mucin-4 before and after non-surgical treatment of peri-implant mucositisHajer A. Aldulaijan0Abeer S. Al-Zawawi1Marwa Y. Shaheen2Dena Ali3Darshan Devang Divakar4Amani M. Basudan5Department of Periodontics and Community Dentistry, College of Dentistry, King Saud UniversityDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud UniversityDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud UniversityDepartment of General Dental Practice, Kuwait UniversityDepartment of Oral Medicine and Radiology, Sharavathi Dental College and HospitalDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud UniversityAbstract Background The present study was based on the null hypothesis that there is no difference in clinicoradiographic parameters and whole salivary alpha amylase (AA) and mucin-4 levels before and after non-surgical mechanical debridement (NSMD) of patients with peri-implant mucositis (PM). The aim was to assess whole salivary AA and mucin-4 levels before and after treatment of PM. Methods Patients with PM (Group-1) and individuals without peri-implant diseases (Group-2) were included. Demographic data was collected and peri-implant modified plaque and bleeding indices (mPI and mBI, respectively), probing depth (PD) and crestal bone loss were measured at baseline. Levels of AA and mucin-4 were assessed in unstimulated whole saliva samples. All patients underwent full-mouth non-surgical periodontal therapy (NSPT) and NSMD; and clinical parameters and salivary biomarkers were re-assessed after 3 months. Level of significance was set at P < 0.01. Results Twenty-six and 32 individuals were included in groups 1 and 2, respectively. None of the participants had periodontitis. At baseline clinical periodontal parameters (PI [P < 0.001], GI [P < 0.001], clinical AL [P < 0.001] and PD [P < 0.001]) were significantly high in Group-1 than Group-2. At 3-month follow-up, there was a statistically significant reduction in clinical periodontal and peri-implant parameters (PI [P < 0.01], GI [P < 0.01], and PD [P < 0.01]) in Group-1 compared with their baseline values. At baseline, salivary AA levels were significantly high in Group-1 than Group-2 (P < 0.01). At 3-month follow-up, there was no significant difference in whole salivary AA levels among patients in groups 1 and 2. Conclusions The AA and mucin-4 levels are potential biomarkers for evaluation of peri-implant diseases including PM. Mechanical instrumentation continues to be the most predictable treatment option for the management of peri-implant diseases.https://doi.org/10.1186/s40729-022-00429-zAlpha amylaseDental implantMechanical debridementMucin-4Peri-implant mucositisWhole saliva |
| spellingShingle | Hajer A. Aldulaijan Abeer S. Al-Zawawi Marwa Y. Shaheen Dena Ali Darshan Devang Divakar Amani M. Basudan Assessment of salivary alpha amylase and mucin-4 before and after non-surgical treatment of peri-implant mucositis International Journal of Implant Dentistry Alpha amylase Dental implant Mechanical debridement Mucin-4 Peri-implant mucositis Whole saliva |
| title | Assessment of salivary alpha amylase and mucin-4 before and after non-surgical treatment of peri-implant mucositis |
| title_full | Assessment of salivary alpha amylase and mucin-4 before and after non-surgical treatment of peri-implant mucositis |
| title_fullStr | Assessment of salivary alpha amylase and mucin-4 before and after non-surgical treatment of peri-implant mucositis |
| title_full_unstemmed | Assessment of salivary alpha amylase and mucin-4 before and after non-surgical treatment of peri-implant mucositis |
| title_short | Assessment of salivary alpha amylase and mucin-4 before and after non-surgical treatment of peri-implant mucositis |
| title_sort | assessment of salivary alpha amylase and mucin 4 before and after non surgical treatment of peri implant mucositis |
| topic | Alpha amylase Dental implant Mechanical debridement Mucin-4 Peri-implant mucositis Whole saliva |
| url | https://doi.org/10.1186/s40729-022-00429-z |
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