Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes.
It is now widely accepted that at an early stage in the evolution of life an RNA world arose, in which RNAs both served as the genetic material and catalyzed diverse biochemical reactions. Then, proteins have gradually replaced RNAs because of their superior catalytic properties in catalysis over ti...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21789260/pdf/?tool=EBI |
| _version_ | 1828897523499008000 |
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| author | Liang Shen Hong-Fang Ji |
| author_facet | Liang Shen Hong-Fang Ji |
| author_sort | Liang Shen |
| collection | DOAJ |
| description | It is now widely accepted that at an early stage in the evolution of life an RNA world arose, in which RNAs both served as the genetic material and catalyzed diverse biochemical reactions. Then, proteins have gradually replaced RNAs because of their superior catalytic properties in catalysis over time. Therefore, it is important to investigate how primitive functional proteins emerged from RNA world, which can shed light on the evolutionary pathway of life from RNA world to the modern world. In this work, we proposed that the emergence of most primitive functional proteins are assisted by the early primitive nucleotide cofactors, while only a minority are induced directly by RNAs based on the analysis of RNA-protein complexes. Furthermore, the present findings have significant implication for exploring the composition of primitive RNA, i.e., adenine base as principal building blocks. |
| first_indexed | 2024-12-13T14:59:17Z |
| format | Article |
| id | doaj.art-ed3ea63154b340b886230db1cafb69a9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T14:59:17Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ed3ea63154b340b886230db1cafb69a92022-12-21T23:41:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0167e2249410.1371/journal.pone.0022494Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes.Liang ShenHong-Fang JiIt is now widely accepted that at an early stage in the evolution of life an RNA world arose, in which RNAs both served as the genetic material and catalyzed diverse biochemical reactions. Then, proteins have gradually replaced RNAs because of their superior catalytic properties in catalysis over time. Therefore, it is important to investigate how primitive functional proteins emerged from RNA world, which can shed light on the evolutionary pathway of life from RNA world to the modern world. In this work, we proposed that the emergence of most primitive functional proteins are assisted by the early primitive nucleotide cofactors, while only a minority are induced directly by RNAs based on the analysis of RNA-protein complexes. Furthermore, the present findings have significant implication for exploring the composition of primitive RNA, i.e., adenine base as principal building blocks.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21789260/pdf/?tool=EBI |
| spellingShingle | Liang Shen Hong-Fang Ji Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes. PLoS ONE |
| title | Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes. |
| title_full | Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes. |
| title_fullStr | Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes. |
| title_full_unstemmed | Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes. |
| title_short | Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes. |
| title_sort | small cofactors may assist protein emergence from rna world clues from rna protein complexes |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21789260/pdf/?tool=EBI |
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