The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline
Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attracted significant attention. Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders. Aging is one of the critical...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=11;spage=2407;epage=2412;aulast=Alsegiani |
| _version_ | 1811244913067556864 |
|---|---|
| author | Amsha S Alsegiani Zahoor A Shah |
| author_facet | Amsha S Alsegiani Zahoor A Shah |
| author_sort | Amsha S Alsegiani |
| collection | DOAJ |
| description | Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attracted significant attention. Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders. Aging is one of the critical predisposing risk factors for the development of neurodegenerative diseases. Maintaining a healthy gut microbiota is essential for a healthy body and aging, but dysbiosis could initiate many chronic diseases. Understanding the underlying mechanisms of gut microbiota alterations/dysbiosis will help identify biomarkers for aging-related chronic conditions. This review summarizes recent advances in microbiota-neurodegenerative disease research and will enhance our understanding of gut microbiota dysbiosis and its effects on brain aging. |
| first_indexed | 2024-04-12T14:32:54Z |
| format | Article |
| id | doaj.art-ed41987e480046b4a8acd5abde41994e |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-12T14:32:54Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-ed41987e480046b4a8acd5abde41994e2022-12-22T03:29:13ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742022-01-0117112407241210.4103/1673-5374.335837The influence of gut microbiota alteration on age-related neuroinflammation and cognitive declineAmsha S AlsegianiZahoor A ShahRecent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attracted significant attention. Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders. Aging is one of the critical predisposing risk factors for the development of neurodegenerative diseases. Maintaining a healthy gut microbiota is essential for a healthy body and aging, but dysbiosis could initiate many chronic diseases. Understanding the underlying mechanisms of gut microbiota alterations/dysbiosis will help identify biomarkers for aging-related chronic conditions. This review summarizes recent advances in microbiota-neurodegenerative disease research and will enhance our understanding of gut microbiota dysbiosis and its effects on brain aging.http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=11;spage=2407;epage=2412;aulast=Alsegianibrain aging; cognitive decline; dysbiosis; fecal microbiota transplantation; gut-microbiota; neuroinflammation; prebiotics; probiotics |
| spellingShingle | Amsha S Alsegiani Zahoor A Shah The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline Neural Regeneration Research brain aging; cognitive decline; dysbiosis; fecal microbiota transplantation; gut-microbiota; neuroinflammation; prebiotics; probiotics |
| title | The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline |
| title_full | The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline |
| title_fullStr | The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline |
| title_full_unstemmed | The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline |
| title_short | The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline |
| title_sort | influence of gut microbiota alteration on age related neuroinflammation and cognitive decline |
| topic | brain aging; cognitive decline; dysbiosis; fecal microbiota transplantation; gut-microbiota; neuroinflammation; prebiotics; probiotics |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=11;spage=2407;epage=2412;aulast=Alsegiani |
| work_keys_str_mv | AT amshasalsegiani theinfluenceofgutmicrobiotaalterationonagerelatedneuroinflammationandcognitivedecline AT zahoorashah theinfluenceofgutmicrobiotaalterationonagerelatedneuroinflammationandcognitivedecline AT amshasalsegiani influenceofgutmicrobiotaalterationonagerelatedneuroinflammationandcognitivedecline AT zahoorashah influenceofgutmicrobiotaalterationonagerelatedneuroinflammationandcognitivedecline |