Sequential administration of paricalcitol followed by IL-17 blockade for progressive refractory IgA nephropathy patients

Sequential administration of paricalcitol followed by IL-17 blockade for progressive refractory IgA nephropathy patients

Abstract There is no established treatment for progressive IgA nephropathy refractory to steroids and immunosuppressant drugs (r-IgAN). Interleukin 17 (IL-17) blockade has garnered interest in immune-mediated diseases involving the gut-kidney axis. However, single IL-17A inhibition induced paradoxic...

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Bibliographic Details
Main Authors: Miguel G. Uriol-Rivera, Aina Obrador-Mulet, Maria Rosa Juliá, Vanessa Daza-Cajigal, Olga Delgado-Sanchez, Angel Garcia Alvarez, Ana Gomez-Lobon, Paula Carrillo-Garcia, Carlos Saus-Sarrias, Cristina Gómez-Cobo, Daniel Ramis-Cabrer, Joan Gasco Company, Javier Molina-Infante, The Balear IgA Research and Treatment Project
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
Inflammation
Interleukin-17A
IgA nephropathy
Vitamin D receptor
Online Access:https://doi.org/10.1038/s41598-024-55425-7

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