Antibiofilm activity of berberine and capsaicin in combination with quinolones against Staphylococcus aureus from bovine mastitis
Antimicrobial resistance which causes failure of antibiotic therapy has become a serious global issue nowadays. Bacteria develop resistance towards an antibacterial agent via many mechanisms. Biofilm formation by bacteria poses severe threat to the treatment of infections. The combination of plan...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Director of Academics and Research, Kerala Veterinary and Animal Sciences University
2022-06-01
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| Series: | Journal of Veterinary and Animal Sciences |
| Subjects: | |
| Online Access: | https://jvas.in/public_html/upload/article_file/article_file_rf9e1p.pdf?t=rf9e1p |
| Summary: | Antimicrobial resistance which causes failure of antibiotic therapy has become a serious global
issue nowadays. Bacteria develop resistance towards an antibacterial agent via many mechanisms.
Biofilm formation by bacteria poses severe threat to the treatment of infections. The combination of
plant molecules with antibiotics can combat antimicrobial resistance. In the present study, antibiofilm
activity of two plant molecules berberine and capsaicin was investigated against Staphylococcus
aureus isolates from bovine mastitis cases. Antibiotic sensitivity testing revealed that berberine
and capsaicin when combined with quinolones increased the diameter of zone of inhibition in
a dose dependent manner. In vitro biofilm assay using congo red agar plate method revealed
the antibiofilm activity of berberine and capsaicin in combination with quinolone antibiotics. The
study concludes that the combination of phytoconstituents with antibiotics can alleviate resistance
mechanisms in bacteria |
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| ISSN: | 0971-0701 2582-0605 |