Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy
This study investigated the development of a novel approach to surface characterization of drug polymorphism and the extension of the capabilities of this method to perform ‘real time’ in situ measurements. This was achieved using diffuse reflectance visible (DRV) spectroscopy and dye deposition, us...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-06-01
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| Series: | Journal of Pharmaceutical Analysis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177915300198 |
| _version_ | 1818407697882546176 |
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| author | Tracy O. Ehiwe Bruce D. Alexander John C. Mitchell Martin J. Snowden Laura J. Waters |
| author_facet | Tracy O. Ehiwe Bruce D. Alexander John C. Mitchell Martin J. Snowden Laura J. Waters |
| author_sort | Tracy O. Ehiwe |
| collection | DOAJ |
| description | This study investigated the development of a novel approach to surface characterization of drug polymorphism and the extension of the capabilities of this method to perform ‘real time’ in situ measurements. This was achieved using diffuse reflectance visible (DRV) spectroscopy and dye deposition, using the pH sensitive dye, thymol blue (TB). Two polymorphs, SFN-β and SFN-γ, of the drug substance sulfanilamide (SFN) were examined. The interaction of adsorbed dye with polymorphs showed different behavior, and thus reported different DRV spectra. Consideration of the acid/base properties of the morphological forms of the drug molecule provided a rationalization of the mechanism of differential coloration by indicator dyes. The kinetics of the polymorphic transformation of SFN polymorphs was monitored using treatment with TB dye and DRV spectroscopy. The thermally-induced transformation fitted a first-order solid-state kinetic model (R2=0.992), giving a rate constant of 2.43×10−2 s−1. |
| first_indexed | 2024-12-14T09:31:58Z |
| format | Article |
| id | doaj.art-ed448107ab1a4d1a8a8de8be452d6cc7 |
| institution | Directory Open Access Journal |
| issn | 2095-1779 |
| language | English |
| last_indexed | 2024-12-14T09:31:58Z |
| publishDate | 2016-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmaceutical Analysis |
| spelling | doaj.art-ed448107ab1a4d1a8a8de8be452d6cc72022-12-21T23:08:02ZengElsevierJournal of Pharmaceutical Analysis2095-17792016-06-016317918310.1016/j.jpha.2015.12.002Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopyTracy O. Ehiwe0Bruce D. Alexander1John C. Mitchell2Martin J. Snowden3Laura J. Waters4Medway Centre for Formulation Science, Faculty of Engineering and Science, University of Greenwich at Medway, Chatham Maritime, Kent ME4 4TB, UKMedway Centre for Formulation Science, Faculty of Engineering and Science, University of Greenwich at Medway, Chatham Maritime, Kent ME4 4TB, UKMedway Centre for Formulation Science, Faculty of Engineering and Science, University of Greenwich at Medway, Chatham Maritime, Kent ME4 4TB, UKMedway Centre for Formulation Science, Faculty of Engineering and Science, University of Greenwich at Medway, Chatham Maritime, Kent ME4 4TB, UKSchool of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UKThis study investigated the development of a novel approach to surface characterization of drug polymorphism and the extension of the capabilities of this method to perform ‘real time’ in situ measurements. This was achieved using diffuse reflectance visible (DRV) spectroscopy and dye deposition, using the pH sensitive dye, thymol blue (TB). Two polymorphs, SFN-β and SFN-γ, of the drug substance sulfanilamide (SFN) were examined. The interaction of adsorbed dye with polymorphs showed different behavior, and thus reported different DRV spectra. Consideration of the acid/base properties of the morphological forms of the drug molecule provided a rationalization of the mechanism of differential coloration by indicator dyes. The kinetics of the polymorphic transformation of SFN polymorphs was monitored using treatment with TB dye and DRV spectroscopy. The thermally-induced transformation fitted a first-order solid-state kinetic model (R2=0.992), giving a rate constant of 2.43×10−2 s−1.http://www.sciencedirect.com/science/article/pii/S2095177915300198Polymorphic transformationSulfanilamideDiffuse reflectance visible spectroscopyPowder X-ray diffractionDifferential scanning calorimetry |
| spellingShingle | Tracy O. Ehiwe Bruce D. Alexander John C. Mitchell Martin J. Snowden Laura J. Waters Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy Journal of Pharmaceutical Analysis Polymorphic transformation Sulfanilamide Diffuse reflectance visible spectroscopy Powder X-ray diffraction Differential scanning calorimetry |
| title | Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy |
| title_full | Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy |
| title_fullStr | Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy |
| title_full_unstemmed | Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy |
| title_short | Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy |
| title_sort | monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy |
| topic | Polymorphic transformation Sulfanilamide Diffuse reflectance visible spectroscopy Powder X-ray diffraction Differential scanning calorimetry |
| url | http://www.sciencedirect.com/science/article/pii/S2095177915300198 |
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