Role of Actin-Binding Proteins in Skeletal Myogenesis
Maintenance of skeletal muscle quantity and quality is essential to ensure various vital functions of the body. Muscle homeostasis is regulated by multiple cytoskeletal proteins and myogenic transcriptional programs responding to endogenous and exogenous signals influencing cell structure and functi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/21/2523 |
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| author | Mai Thi Nguyen Raju Dash Kyuho Jeong Wan Lee |
| author_facet | Mai Thi Nguyen Raju Dash Kyuho Jeong Wan Lee |
| author_sort | Mai Thi Nguyen |
| collection | DOAJ |
| description | Maintenance of skeletal muscle quantity and quality is essential to ensure various vital functions of the body. Muscle homeostasis is regulated by multiple cytoskeletal proteins and myogenic transcriptional programs responding to endogenous and exogenous signals influencing cell structure and function. Since actin is an essential component in cytoskeleton dynamics, actin-binding proteins (ABPs) have been recognized as crucial players in skeletal muscle health and diseases. Hence, dysregulation of ABPs leads to muscle atrophy characterized by loss of mass, strength, quality, and capacity for regeneration. This comprehensive review summarizes the recent studies that have unveiled the role of ABPs in actin cytoskeletal dynamics, with a particular focus on skeletal myogenesis and diseases. This provides insight into the molecular mechanisms that regulate skeletal myogenesis via ABPs as well as research avenues to identify potential therapeutic targets. Moreover, this review explores the implications of non-coding RNAs (ncRNAs) targeting ABPs in skeletal myogenesis and disorders based on recent achievements in ncRNA research. The studies presented here will enhance our understanding of the functional significance of ABPs and mechanotransduction-derived myogenic regulatory mechanisms. Furthermore, revealing how ncRNAs regulate ABPs will allow diverse therapeutic approaches for skeletal muscle disorders to be developed. |
| first_indexed | 2024-03-11T11:33:08Z |
| format | Article |
| id | doaj.art-ed453aee35f048dfaf3bfd94455a5f2c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T11:33:08Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-ed453aee35f048dfaf3bfd94455a5f2c2023-11-10T15:00:38ZengMDPI AGCells2073-44092023-10-011221252310.3390/cells12212523Role of Actin-Binding Proteins in Skeletal MyogenesisMai Thi Nguyen0Raju Dash1Kyuho Jeong2Wan Lee3Department of Biochemistry, Dongguk University College of Medicine, 123 Dongdae-ro, Gyeongju 38066, Republic of KoreaDepartment of Anatomy, Dongguk University College of Medicine, 123 Dongdae-ro, Gyeongju 38066, Republic of KoreaDepartment of Biochemistry, Dongguk University College of Medicine, 123 Dongdae-ro, Gyeongju 38066, Republic of KoreaDepartment of Biochemistry, Dongguk University College of Medicine, 123 Dongdae-ro, Gyeongju 38066, Republic of KoreaMaintenance of skeletal muscle quantity and quality is essential to ensure various vital functions of the body. Muscle homeostasis is regulated by multiple cytoskeletal proteins and myogenic transcriptional programs responding to endogenous and exogenous signals influencing cell structure and function. Since actin is an essential component in cytoskeleton dynamics, actin-binding proteins (ABPs) have been recognized as crucial players in skeletal muscle health and diseases. Hence, dysregulation of ABPs leads to muscle atrophy characterized by loss of mass, strength, quality, and capacity for regeneration. This comprehensive review summarizes the recent studies that have unveiled the role of ABPs in actin cytoskeletal dynamics, with a particular focus on skeletal myogenesis and diseases. This provides insight into the molecular mechanisms that regulate skeletal myogenesis via ABPs as well as research avenues to identify potential therapeutic targets. Moreover, this review explores the implications of non-coding RNAs (ncRNAs) targeting ABPs in skeletal myogenesis and disorders based on recent achievements in ncRNA research. The studies presented here will enhance our understanding of the functional significance of ABPs and mechanotransduction-derived myogenic regulatory mechanisms. Furthermore, revealing how ncRNAs regulate ABPs will allow diverse therapeutic approaches for skeletal muscle disorders to be developed.https://www.mdpi.com/2073-4409/12/21/2523actin-binding proteinsactin dynamicsmyogenesisdifferentiationproliferationnon-coding RNA |
| spellingShingle | Mai Thi Nguyen Raju Dash Kyuho Jeong Wan Lee Role of Actin-Binding Proteins in Skeletal Myogenesis Cells actin-binding proteins actin dynamics myogenesis differentiation proliferation non-coding RNA |
| title | Role of Actin-Binding Proteins in Skeletal Myogenesis |
| title_full | Role of Actin-Binding Proteins in Skeletal Myogenesis |
| title_fullStr | Role of Actin-Binding Proteins in Skeletal Myogenesis |
| title_full_unstemmed | Role of Actin-Binding Proteins in Skeletal Myogenesis |
| title_short | Role of Actin-Binding Proteins in Skeletal Myogenesis |
| title_sort | role of actin binding proteins in skeletal myogenesis |
| topic | actin-binding proteins actin dynamics myogenesis differentiation proliferation non-coding RNA |
| url | https://www.mdpi.com/2073-4409/12/21/2523 |
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