Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids
The mechanisms of tumor heterogeneity in pediatric hepatoblastoma remain poorly characterized. Here, the authors perform single cell RNA sequencing and identify 5 signatures with distinct responses to chemotherapy using patient-derived hepatoblastoma spheroid cultures.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32473-z |
| _version_ | 1811188776245919744 |
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| author | Hanbing Song Simon Bucher Katherine Rosenberg Margaret Tsui Deviana Burhan Daniel Hoffman Soo-Jin Cho Arun Rangaswami Marcus Breese Stanley Leung María V. Pons Ventura E. Alejandro Sweet-Cordero Franklin W. Huang Amar Nijagal Bruce Wang |
| author_facet | Hanbing Song Simon Bucher Katherine Rosenberg Margaret Tsui Deviana Burhan Daniel Hoffman Soo-Jin Cho Arun Rangaswami Marcus Breese Stanley Leung María V. Pons Ventura E. Alejandro Sweet-Cordero Franklin W. Huang Amar Nijagal Bruce Wang |
| author_sort | Hanbing Song |
| collection | DOAJ |
| description | The mechanisms of tumor heterogeneity in pediatric hepatoblastoma remain poorly characterized. Here, the authors perform single cell RNA sequencing and identify 5 signatures with distinct responses to chemotherapy using patient-derived hepatoblastoma spheroid cultures. |
| first_indexed | 2024-04-11T14:24:59Z |
| format | Article |
| id | doaj.art-ed471fb670d543c7baf6824b29a078f2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T14:24:59Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ed471fb670d543c7baf6824b29a078f22022-12-22T04:18:55ZengNature PortfolioNature Communications2041-17232022-08-0113111510.1038/s41467-022-32473-zSingle-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroidsHanbing Song0Simon Bucher1Katherine Rosenberg2Margaret Tsui3Deviana Burhan4Daniel Hoffman5Soo-Jin Cho6Arun Rangaswami7Marcus Breese8Stanley Leung9María V. Pons Ventura10E. Alejandro Sweet-Cordero11Franklin W. Huang12Amar Nijagal13Bruce Wang14Division of Hematology and Oncology, Department of Medicine, University of California, San FranciscoDivision of Gastroenterology, Department of Medicine, University of California, San FranciscoThe Liver Center, University of California, San FranciscoHelen Diller Family Comprehensive Cancer Center, University of California, San FranciscoDivision of Gastroenterology, Department of Medicine, University of California, San FranciscoThe Liver Center, University of California, San FranciscoDepartment of Pathology, University of California, San FranciscoThe Pediatric Liver Center at UCSF Benioff Childrens’ HospitalsDivision of Oncology, Department of Pediatrics, University of California, San FranciscoDivision of Oncology, Department of Pediatrics, University of California, San FranciscoDivision of Oncology, Department of Pediatrics, University of California, San FranciscoThe Pediatric Liver Center at UCSF Benioff Childrens’ HospitalsDivision of Hematology and Oncology, Department of Medicine, University of California, San FranciscoHelen Diller Family Comprehensive Cancer Center, University of California, San FranciscoHelen Diller Family Comprehensive Cancer Center, University of California, San FranciscoThe mechanisms of tumor heterogeneity in pediatric hepatoblastoma remain poorly characterized. Here, the authors perform single cell RNA sequencing and identify 5 signatures with distinct responses to chemotherapy using patient-derived hepatoblastoma spheroid cultures.https://doi.org/10.1038/s41467-022-32473-z |
| spellingShingle | Hanbing Song Simon Bucher Katherine Rosenberg Margaret Tsui Deviana Burhan Daniel Hoffman Soo-Jin Cho Arun Rangaswami Marcus Breese Stanley Leung María V. Pons Ventura E. Alejandro Sweet-Cordero Franklin W. Huang Amar Nijagal Bruce Wang Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids Nature Communications |
| title | Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids |
| title_full | Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids |
| title_fullStr | Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids |
| title_full_unstemmed | Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids |
| title_short | Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids |
| title_sort | single cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient specific tumor spheroids |
| url | https://doi.org/10.1038/s41467-022-32473-z |
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