Pallidal Structural Changes Related to Levodopa-induced Dyskinesia in Parkinson's Disease
BackgroundDespite the clinical impact of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD), the mechanism, especially the role of basal ganglia (BG), is not fully elucidated yet. We investigated the BG structural changes related to LID in PD using a surface-based shape analysis tech...
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| Format: | Article |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.781883/full |
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| author | Jinyoung Youn Jinyoung Youn Mansu Kim Suyeon Park Ji Sun Kim Ji Sun Kim Hyunjin Park Hyunjin Park Jin Whan Cho Jin Whan Cho |
| author_facet | Jinyoung Youn Jinyoung Youn Mansu Kim Suyeon Park Ji Sun Kim Ji Sun Kim Hyunjin Park Hyunjin Park Jin Whan Cho Jin Whan Cho |
| author_sort | Jinyoung Youn |
| collection | DOAJ |
| description | BackgroundDespite the clinical impact of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD), the mechanism, especially the role of basal ganglia (BG), is not fully elucidated yet. We investigated the BG structural changes related to LID in PD using a surface-based shape analysis technique.MethodsWe recruited patients with PD who developed LID within 3 years (LID group, 28 patients) and who did not develop it after 7 years (non-LID group, 35 patients) from levodopa treatment for the extreme case-control study. BG structure volumes were measured using volumetry analysis and the surface-based morphometry feature (i.e., Jacobian) from the subcortical surface vertices. We compared the volume and Jacobian of meshes in the regions between the two groups. We also performed a correlation analysis between local atrophy and the severity of LID. Additionally, we evaluated structural connectivity profiles from globus pallidus interna and externa (GPi and GPe) to other brain structures based on the group comparison.ResultsThe demographic and clinical data showed no significant difference except for disease duration, treatment duration, parkinsonism severity, and levodopa equivalent dose. The LID group had more local atrophies of vertices in the right GPi than the non-LID group, despite no difference in volumes. Furthermore, the LID group demonstrated significantly reduced structural connectivity between left GPi and thalamus.ConclusionThis is the first demonstration of distinct shape alterations of basal ganglia structures, especially GPi, related to LID in PD. Considering both direct and indirect BG pathways share the connection between GPi and thalamus, the BG pathway plays a crucial role in the development of LID. |
| first_indexed | 2024-04-13T08:24:04Z |
| format | Article |
| id | doaj.art-ed47bb0137ab4873947c0def5255a526 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T08:24:04Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-ed47bb0137ab4873947c0def5255a5262022-12-22T02:54:33ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-05-011410.3389/fnagi.2022.781883781883Pallidal Structural Changes Related to Levodopa-induced Dyskinesia in Parkinson's DiseaseJinyoung Youn0Jinyoung Youn1Mansu Kim2Suyeon Park3Ji Sun Kim4Ji Sun Kim5Hyunjin Park6Hyunjin Park7Jin Whan Cho8Jin Whan Cho9Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaNeuroscience Center, Samsung Medical Center, Seoul, South KoreaDepartment of Artificial Intelligence, Catholic University of Korea, Bucheon, South KoreaDepartment of Biostatistics, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, South KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaNeuroscience Center, Samsung Medical Center, Seoul, South KoreaCenter for Neuroscience Imaging Research, Institute for Basic Science, Suwon, South KoreaSchool of Electronic and Electrical Engineering, Sungkyunkwan University, Suwon, South KoreaDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaNeuroscience Center, Samsung Medical Center, Seoul, South KoreaBackgroundDespite the clinical impact of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD), the mechanism, especially the role of basal ganglia (BG), is not fully elucidated yet. We investigated the BG structural changes related to LID in PD using a surface-based shape analysis technique.MethodsWe recruited patients with PD who developed LID within 3 years (LID group, 28 patients) and who did not develop it after 7 years (non-LID group, 35 patients) from levodopa treatment for the extreme case-control study. BG structure volumes were measured using volumetry analysis and the surface-based morphometry feature (i.e., Jacobian) from the subcortical surface vertices. We compared the volume and Jacobian of meshes in the regions between the two groups. We also performed a correlation analysis between local atrophy and the severity of LID. Additionally, we evaluated structural connectivity profiles from globus pallidus interna and externa (GPi and GPe) to other brain structures based on the group comparison.ResultsThe demographic and clinical data showed no significant difference except for disease duration, treatment duration, parkinsonism severity, and levodopa equivalent dose. The LID group had more local atrophies of vertices in the right GPi than the non-LID group, despite no difference in volumes. Furthermore, the LID group demonstrated significantly reduced structural connectivity between left GPi and thalamus.ConclusionThis is the first demonstration of distinct shape alterations of basal ganglia structures, especially GPi, related to LID in PD. Considering both direct and indirect BG pathways share the connection between GPi and thalamus, the BG pathway plays a crucial role in the development of LID.https://www.frontiersin.org/articles/10.3389/fnagi.2022.781883/fulldyskinesialevodopa-induced dyskinesiabasal gangliaglobus palliduspallidumParkinson's disease |
| spellingShingle | Jinyoung Youn Jinyoung Youn Mansu Kim Suyeon Park Ji Sun Kim Ji Sun Kim Hyunjin Park Hyunjin Park Jin Whan Cho Jin Whan Cho Pallidal Structural Changes Related to Levodopa-induced Dyskinesia in Parkinson's Disease Frontiers in Aging Neuroscience dyskinesia levodopa-induced dyskinesia basal ganglia globus pallidus pallidum Parkinson's disease |
| title | Pallidal Structural Changes Related to Levodopa-induced Dyskinesia in Parkinson's Disease |
| title_full | Pallidal Structural Changes Related to Levodopa-induced Dyskinesia in Parkinson's Disease |
| title_fullStr | Pallidal Structural Changes Related to Levodopa-induced Dyskinesia in Parkinson's Disease |
| title_full_unstemmed | Pallidal Structural Changes Related to Levodopa-induced Dyskinesia in Parkinson's Disease |
| title_short | Pallidal Structural Changes Related to Levodopa-induced Dyskinesia in Parkinson's Disease |
| title_sort | pallidal structural changes related to levodopa induced dyskinesia in parkinson s disease |
| topic | dyskinesia levodopa-induced dyskinesia basal ganglia globus pallidus pallidum Parkinson's disease |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.781883/full |
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