IgE is associated with exacerbations and lung function decline in COPD
Abstract Background Both allergen-specific IgE and total IgE in serum play a major role in asthma. However, the role of IgE in chronic obstructive pulmonary disease (COPD) is poorly understood. It was the aim of this study to systematically analyze the relationship between serum IgE levels and disea...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-021-01847-0 |
| _version_ | 1818964056702189568 |
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| author | Marek Lommatzsch Timotheus Speer Christian Herr Rudolf A. Jörres Henrik Watz Achim Müller Tobias Welte Claus F. Vogelmeier Robert Bals for the COSYCONET study group |
| author_facet | Marek Lommatzsch Timotheus Speer Christian Herr Rudolf A. Jörres Henrik Watz Achim Müller Tobias Welte Claus F. Vogelmeier Robert Bals for the COSYCONET study group |
| author_sort | Marek Lommatzsch |
| collection | DOAJ |
| description | Abstract Background Both allergen-specific IgE and total IgE in serum play a major role in asthma. However, the role of IgE in chronic obstructive pulmonary disease (COPD) is poorly understood. It was the aim of this study to systematically analyze the relationship between serum IgE levels and disease characteristics in large COPD cohorts. Methods COSYCONET is a comprehensively characterized cohort of patients with COPD: total IgE and IgE specific to common aeroallergens were measured in serum of 2280 patients, and related to clinical characteristics of the patients. WISDOM is another large COPD population (2477 patients): this database contains the information whether total IgE in serum was elevated (≥ 100 IU/l) or normal in patients with COPD. Results Both in COSYCONET and WISDOM, total IgE was elevated (≥ 100 IU/l) in > 30% of the patients, higher in men than in women, and higher in currently than in not currently smoking men. In COSYCONET, total IgE was elevated in patients with a history of asthma and/or allergies. Men with at least one exacerbation in the last 12 months (50.6% of all men in COSYCONET) had higher median total IgE (71.3 IU/l) than men without exacerbations (48.3 IU/l): this difference was also observed in the subgroups of not currently smoking men and of men without a history of asthma. Surprisingly, a history of exacerbations did not impact on total IgE in women with COPD. Patients in the highest tertiles of total IgE (> 91.5 IU/ml, adjusted OR: 1.62, 95% CI 1.12–2.34) or allergen-specific IgE (> 0.19 IU/ml, adjusted OR: 2.15, 95% CI 1.32–3.51) were at risk of lung function decline (adjusted by: age, gender, body mass index, initial lung function, smoking status, history of asthma, history of allergy). Conclusion These data suggest that IgE may play a role in specific COPD subgroups. Clinical trials using antibodies targeting the IgE pathway (such as omalizumab), especially in men with recurrent exacerbations and elevated serum IgE, could elucidate potential therapeutic implications of our observations. |
| first_indexed | 2024-12-20T12:55:03Z |
| format | Article |
| id | doaj.art-ed4845884ee043c081b5a530246202d6 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-12-20T12:55:03Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-ed4845884ee043c081b5a530246202d62022-12-21T19:40:05ZengBMCRespiratory Research1465-993X2022-01-012311910.1186/s12931-021-01847-0IgE is associated with exacerbations and lung function decline in COPDMarek Lommatzsch0Timotheus Speer1Christian Herr2Rudolf A. Jörres3Henrik Watz4Achim Müller5Tobias Welte6Claus F. Vogelmeier7Robert Bals8for the COSYCONET study groupUniversity of RostockDepartment of Internal Medicine IV, Nephrology, Saarland University HospitalDepartment of Internal Medicine V - Pulmonology, Allergology, Critical Care Medicine, Saarland University Medical CenterUniversity of MunichAirway Research Center North (ARCN), German Center for Lung Research (DZL), Pulmonary Research Institute at LungenClinic GrosshansdorfBoehringer Ingelheim Pharma GmbH & Co. KGGerman Center for Lung Research (DZL), University of HannoverGerman Center for Lung Research (DZL), Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-Universität MarburgDepartment of Internal Medicine V - Pulmonology, Allergology, Critical Care Medicine, Saarland University Medical CenterAbstract Background Both allergen-specific IgE and total IgE in serum play a major role in asthma. However, the role of IgE in chronic obstructive pulmonary disease (COPD) is poorly understood. It was the aim of this study to systematically analyze the relationship between serum IgE levels and disease characteristics in large COPD cohorts. Methods COSYCONET is a comprehensively characterized cohort of patients with COPD: total IgE and IgE specific to common aeroallergens were measured in serum of 2280 patients, and related to clinical characteristics of the patients. WISDOM is another large COPD population (2477 patients): this database contains the information whether total IgE in serum was elevated (≥ 100 IU/l) or normal in patients with COPD. Results Both in COSYCONET and WISDOM, total IgE was elevated (≥ 100 IU/l) in > 30% of the patients, higher in men than in women, and higher in currently than in not currently smoking men. In COSYCONET, total IgE was elevated in patients with a history of asthma and/or allergies. Men with at least one exacerbation in the last 12 months (50.6% of all men in COSYCONET) had higher median total IgE (71.3 IU/l) than men without exacerbations (48.3 IU/l): this difference was also observed in the subgroups of not currently smoking men and of men without a history of asthma. Surprisingly, a history of exacerbations did not impact on total IgE in women with COPD. Patients in the highest tertiles of total IgE (> 91.5 IU/ml, adjusted OR: 1.62, 95% CI 1.12–2.34) or allergen-specific IgE (> 0.19 IU/ml, adjusted OR: 2.15, 95% CI 1.32–3.51) were at risk of lung function decline (adjusted by: age, gender, body mass index, initial lung function, smoking status, history of asthma, history of allergy). Conclusion These data suggest that IgE may play a role in specific COPD subgroups. Clinical trials using antibodies targeting the IgE pathway (such as omalizumab), especially in men with recurrent exacerbations and elevated serum IgE, could elucidate potential therapeutic implications of our observations.https://doi.org/10.1186/s12931-021-01847-0COPDIgEExacerbationsLung function decline |
| spellingShingle | Marek Lommatzsch Timotheus Speer Christian Herr Rudolf A. Jörres Henrik Watz Achim Müller Tobias Welte Claus F. Vogelmeier Robert Bals for the COSYCONET study group IgE is associated with exacerbations and lung function decline in COPD Respiratory Research COPD IgE Exacerbations Lung function decline |
| title | IgE is associated with exacerbations and lung function decline in COPD |
| title_full | IgE is associated with exacerbations and lung function decline in COPD |
| title_fullStr | IgE is associated with exacerbations and lung function decline in COPD |
| title_full_unstemmed | IgE is associated with exacerbations and lung function decline in COPD |
| title_short | IgE is associated with exacerbations and lung function decline in COPD |
| title_sort | ige is associated with exacerbations and lung function decline in copd |
| topic | COPD IgE Exacerbations Lung function decline |
| url | https://doi.org/10.1186/s12931-021-01847-0 |
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