Cardiotonic Steroids as Modulators of Neuroinflammation
Cardiotonic steroids (CTS) are a class of specific ligands of the Na+,K+- ATPase (NKA). NKA is a P-type ATPase that is ubiquitously expressed and although well known to be responsible for the maintenance of the cell electrochemical gradient through active transport, NKA can also act as a signal tran...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-02-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00010/full |
| _version_ | 1818487870199955456 |
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| author | Ana Maria Marques Orellana Paula Fernanda Kinoshita Jacqueline Alves Leite Elisa Mitiko Kawamoto Cristoforo eScavone |
| author_facet | Ana Maria Marques Orellana Paula Fernanda Kinoshita Jacqueline Alves Leite Elisa Mitiko Kawamoto Cristoforo eScavone |
| author_sort | Ana Maria Marques Orellana |
| collection | DOAJ |
| description | Cardiotonic steroids (CTS) are a class of specific ligands of the Na+,K+- ATPase (NKA). NKA is a P-type ATPase that is ubiquitously expressed and although well known to be responsible for the maintenance of the cell electrochemical gradient through active transport, NKA can also act as a signal transducer in the presence of CTS. Inflammation, in addition to importantly driving organism defense and survival mechanisms, can also modulate NKA activity and memory formation, as well as being relevant to many chronic illnesses, neurodegenerative diseases and mood disorders. The aim of the current review is to highlight the recent advances as to the role of CTS and NKA in inflammatory process, with a particular focus in the central nervous system. |
| first_indexed | 2024-12-10T16:43:36Z |
| format | Article |
| id | doaj.art-ed493f42db374162b0c59ed13d3b459c |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T16:43:36Z |
| publishDate | 2016-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-ed493f42db374162b0c59ed13d3b459c2022-12-22T01:41:08ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922016-02-01710.3389/fendo.2016.00010175588Cardiotonic Steroids as Modulators of NeuroinflammationAna Maria Marques Orellana0Paula Fernanda Kinoshita1Jacqueline Alves Leite2Elisa Mitiko Kawamoto3Cristoforo eScavone4University of São PauloUniversity of São PauloUniversity of São PauloUniversity of São PauloUniversity of São PauloCardiotonic steroids (CTS) are a class of specific ligands of the Na+,K+- ATPase (NKA). NKA is a P-type ATPase that is ubiquitously expressed and although well known to be responsible for the maintenance of the cell electrochemical gradient through active transport, NKA can also act as a signal transducer in the presence of CTS. Inflammation, in addition to importantly driving organism defense and survival mechanisms, can also modulate NKA activity and memory formation, as well as being relevant to many chronic illnesses, neurodegenerative diseases and mood disorders. The aim of the current review is to highlight the recent advances as to the role of CTS and NKA in inflammatory process, with a particular focus in the central nervous system.http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00010/fullImmunomodulationInflammationCardiotonic steroidsNKANFKB and Ouabain. |
| spellingShingle | Ana Maria Marques Orellana Paula Fernanda Kinoshita Jacqueline Alves Leite Elisa Mitiko Kawamoto Cristoforo eScavone Cardiotonic Steroids as Modulators of Neuroinflammation Frontiers in Endocrinology Immunomodulation Inflammation Cardiotonic steroids NKA NFKB and Ouabain. |
| title | Cardiotonic Steroids as Modulators of Neuroinflammation |
| title_full | Cardiotonic Steroids as Modulators of Neuroinflammation |
| title_fullStr | Cardiotonic Steroids as Modulators of Neuroinflammation |
| title_full_unstemmed | Cardiotonic Steroids as Modulators of Neuroinflammation |
| title_short | Cardiotonic Steroids as Modulators of Neuroinflammation |
| title_sort | cardiotonic steroids as modulators of neuroinflammation |
| topic | Immunomodulation Inflammation Cardiotonic steroids NKA NFKB and Ouabain. |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00010/full |
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