Design of artificial vascular devices: Hemodynamic evaluation of shear-induced thrombogenicity
Blood-circulating devices such as oxygenators have offered life-saving opportunities for advanced cardiovascular and pulmonary failures. However, such systems are limited in the mimicking of the native vascular environment (architecture, mechanical forces, operating flow rates and scaffold compositi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Mechanical Engineering |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmech.2023.1060580/full |
| _version_ | 1797901837851951104 |
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| author | Thomas Feaugas Thomas Feaugas Gwenyth Newman Gwenyth Newman Silvia Tea Calzuola Silvia Tea Calzuola Alison Domingues William Arditi William Arditi Constance Porrini Emmanuel Roy Cecile M. Perrault |
| author_facet | Thomas Feaugas Thomas Feaugas Gwenyth Newman Gwenyth Newman Silvia Tea Calzuola Silvia Tea Calzuola Alison Domingues William Arditi William Arditi Constance Porrini Emmanuel Roy Cecile M. Perrault |
| author_sort | Thomas Feaugas |
| collection | DOAJ |
| description | Blood-circulating devices such as oxygenators have offered life-saving opportunities for advanced cardiovascular and pulmonary failures. However, such systems are limited in the mimicking of the native vascular environment (architecture, mechanical forces, operating flow rates and scaffold compositions). Complications involving thrombosis considerably reduce their implementation time and require intensive anticoagulant treatment. Variations in the hemodynamic forces and fluid-mediated interactions between the different blood components determine the risk of thrombosis and are generally not taken sufficiently into consideration in the design of new blood-circulating devices. In this Review article, we examine the tools and investigations around hemodynamics employed in the development of artificial vascular devices, and especially with advanced microfluidics techniques. Firstly, the architecture of the human vascular system will be discussed, with regards to achieving physiological functions while maintaining antithrombotic conditions for the blood. The aim is to highlight that blood circulation in native vessels is a finely controlled balance between architecture, rheology and mechanical forces, altogether providing valuable biomimetics concepts. Later, we summarize the current numerical and experimental methodologies to assess the risk of thrombogenicity of flow patterns in blood circulating devices. We show that the leveraging of both local hemodynamic analysis and nature-inspired architectures can greatly contribute to the development of predictive models of device thrombogenicity. When integrated in the early phase of the design, such evaluation would pave the way for optimised blood circulating systems with effective thromboresistance performances, long-term implantation prospects and a reduced burden for patients. |
| first_indexed | 2024-04-10T09:08:15Z |
| format | Article |
| id | doaj.art-ed4a2016a75c4b30a994e40b233c97e3 |
| institution | Directory Open Access Journal |
| issn | 2297-3079 |
| language | English |
| last_indexed | 2024-04-10T09:08:15Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Mechanical Engineering |
| spelling | doaj.art-ed4a2016a75c4b30a994e40b233c97e32023-02-21T05:58:36ZengFrontiers Media S.A.Frontiers in Mechanical Engineering2297-30792023-02-01910.3389/fmech.2023.10605801060580Design of artificial vascular devices: Hemodynamic evaluation of shear-induced thrombogenicityThomas Feaugas0Thomas Feaugas1Gwenyth Newman2Gwenyth Newman3Silvia Tea Calzuola4Silvia Tea Calzuola5Alison Domingues6William Arditi7William Arditi8Constance Porrini9Emmanuel Roy10Cecile M. Perrault11Department of Medicine and Surgery, Università degli Studi di Milano-Bicocca, Milan, ItalyEden Tech, Paris, FranceDepartment of Medicine and Surgery, Università degli Studi di Milano-Bicocca, Milan, ItalyEden Tech, Paris, FranceEden Tech, Paris, FranceUMR7648—LadHyX, Ecole Polytechnique, Palaiseau, FranceUniversité Paris Cité, INSERM, Innovations Thérapeutiques en Hémostase UMR-S 1140, Paris, FranceEden Tech, Paris, FranceCentrale Supélec, Gif-sur-Yvette, Île-de-France, FranceEden Tech, Paris, FranceEden Tech, Paris, FranceEden Tech, Paris, FranceBlood-circulating devices such as oxygenators have offered life-saving opportunities for advanced cardiovascular and pulmonary failures. However, such systems are limited in the mimicking of the native vascular environment (architecture, mechanical forces, operating flow rates and scaffold compositions). Complications involving thrombosis considerably reduce their implementation time and require intensive anticoagulant treatment. Variations in the hemodynamic forces and fluid-mediated interactions between the different blood components determine the risk of thrombosis and are generally not taken sufficiently into consideration in the design of new blood-circulating devices. In this Review article, we examine the tools and investigations around hemodynamics employed in the development of artificial vascular devices, and especially with advanced microfluidics techniques. Firstly, the architecture of the human vascular system will be discussed, with regards to achieving physiological functions while maintaining antithrombotic conditions for the blood. The aim is to highlight that blood circulation in native vessels is a finely controlled balance between architecture, rheology and mechanical forces, altogether providing valuable biomimetics concepts. Later, we summarize the current numerical and experimental methodologies to assess the risk of thrombogenicity of flow patterns in blood circulating devices. We show that the leveraging of both local hemodynamic analysis and nature-inspired architectures can greatly contribute to the development of predictive models of device thrombogenicity. When integrated in the early phase of the design, such evaluation would pave the way for optimised blood circulating systems with effective thromboresistance performances, long-term implantation prospects and a reduced burden for patients.https://www.frontiersin.org/articles/10.3389/fmech.2023.1060580/fullthrombosisartificial vesselsbiomechanicsshear stresscomputational fluid dynamicsbiocompability |
| spellingShingle | Thomas Feaugas Thomas Feaugas Gwenyth Newman Gwenyth Newman Silvia Tea Calzuola Silvia Tea Calzuola Alison Domingues William Arditi William Arditi Constance Porrini Emmanuel Roy Cecile M. Perrault Design of artificial vascular devices: Hemodynamic evaluation of shear-induced thrombogenicity Frontiers in Mechanical Engineering thrombosis artificial vessels biomechanics shear stress computational fluid dynamics biocompability |
| title | Design of artificial vascular devices: Hemodynamic evaluation of shear-induced thrombogenicity |
| title_full | Design of artificial vascular devices: Hemodynamic evaluation of shear-induced thrombogenicity |
| title_fullStr | Design of artificial vascular devices: Hemodynamic evaluation of shear-induced thrombogenicity |
| title_full_unstemmed | Design of artificial vascular devices: Hemodynamic evaluation of shear-induced thrombogenicity |
| title_short | Design of artificial vascular devices: Hemodynamic evaluation of shear-induced thrombogenicity |
| title_sort | design of artificial vascular devices hemodynamic evaluation of shear induced thrombogenicity |
| topic | thrombosis artificial vessels biomechanics shear stress computational fluid dynamics biocompability |
| url | https://www.frontiersin.org/articles/10.3389/fmech.2023.1060580/full |
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