Chemoembolization with HepaSpheres as a stage of comprehensive treatment for malignant pelvic tumors
Genital bleeding poses a serious threat to patients with progressive locally advanced malignant tumors. Surgical treatment is often impossible in these patients; therefore, to achieve reliable hemostasis, the patients should undergo embolization of vessels feeding the tumor. Good results have been a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2019-02-01
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| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/617 |
| _version_ | 1797876043575459840 |
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| author | A. G. Kedrova D. P. Lebedev D. A. Astakhov V. V. Kosyy F. G. Zabozlaev R. V. Ishchenko |
| author_facet | A. G. Kedrova D. P. Lebedev D. A. Astakhov V. V. Kosyy F. G. Zabozlaev R. V. Ishchenko |
| author_sort | A. G. Kedrova |
| collection | DOAJ |
| description | Genital bleeding poses a serious threat to patients with progressive locally advanced malignant tumors. Surgical treatment is often impossible in these patients; therefore, to achieve reliable hemostasis, the patients should undergo embolization of vessels feeding the tumor. Good results have been achieved by selective catheterization of pelvic arteries using chemoembolization with HepaSphere microspheres (Biosphere Medical, France) delivering the therapeutic agent to the tumor. Hydrophilicity of microspheres loaded with cytostatics and their biological compatibility with tissues ensure long-term therapeutic effect by controlling tumor growth. Pronounced hemostatic and antitumor effects of this treatment method have been confirmed by a morphological study. This study analyzes 38 patients that underwent chemoembolization with HepaSpheres loaded with doxorubicin or irinotecan, which allowed surgery and further treatment. |
| first_indexed | 2024-04-10T01:55:58Z |
| format | Article |
| id | doaj.art-ed4dd679a31a456b815ba4796f1a1a08 |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2024-04-10T01:55:58Z |
| publishDate | 2019-02-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-ed4dd679a31a456b815ba4796f1a1a082023-03-13T08:44:37ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272019-02-01144354210.17650/1994-4098-2018-14-4-35-42593Chemoembolization with HepaSpheres as a stage of comprehensive treatment for malignant pelvic tumorsA. G. Kedrova0D. P. Lebedev1D. A. Astakhov2V. V. Kosyy3F. G. Zabozlaev4R. V. Ishchenko5ФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства России» (ФНКЦ ФМБА России); Академии постдипломного образования ФГБУ ФНКЦ ФМБА РоссииФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства России» (ФНКЦ ФМБА России)ФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства России» (ФНКЦ ФМБА России)ФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства России» (ФНКЦ ФМБА России)ФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства России» (ФНКЦ ФМБА России); Академии постдипломного образования ФГБУ ФНКЦ ФМБА РоссииФГБУ «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства России» (ФНКЦ ФМБА России)Genital bleeding poses a serious threat to patients with progressive locally advanced malignant tumors. Surgical treatment is often impossible in these patients; therefore, to achieve reliable hemostasis, the patients should undergo embolization of vessels feeding the tumor. Good results have been achieved by selective catheterization of pelvic arteries using chemoembolization with HepaSphere microspheres (Biosphere Medical, France) delivering the therapeutic agent to the tumor. Hydrophilicity of microspheres loaded with cytostatics and their biological compatibility with tissues ensure long-term therapeutic effect by controlling tumor growth. Pronounced hemostatic and antitumor effects of this treatment method have been confirmed by a morphological study. This study analyzes 38 patients that underwent chemoembolization with HepaSpheres loaded with doxorubicin or irinotecan, which allowed surgery and further treatment.https://ojrs.abvpress.ru/ojrs/article/view/617артериальная химиоэмболизациярецидивы рака шейки и тела маткирецидив саркомы маткиэмболизация маточных артерийhepasphereостановка кровотечения |
| spellingShingle | A. G. Kedrova D. P. Lebedev D. A. Astakhov V. V. Kosyy F. G. Zabozlaev R. V. Ishchenko Chemoembolization with HepaSpheres as a stage of comprehensive treatment for malignant pelvic tumors Опухоли женской репродуктивной системы артериальная химиоэмболизация рецидивы рака шейки и тела матки рецидив саркомы матки эмболизация маточных артерий hepasphere остановка кровотечения |
| title | Chemoembolization with HepaSpheres as a stage of comprehensive treatment for malignant pelvic tumors |
| title_full | Chemoembolization with HepaSpheres as a stage of comprehensive treatment for malignant pelvic tumors |
| title_fullStr | Chemoembolization with HepaSpheres as a stage of comprehensive treatment for malignant pelvic tumors |
| title_full_unstemmed | Chemoembolization with HepaSpheres as a stage of comprehensive treatment for malignant pelvic tumors |
| title_short | Chemoembolization with HepaSpheres as a stage of comprehensive treatment for malignant pelvic tumors |
| title_sort | chemoembolization with hepaspheres as a stage of comprehensive treatment for malignant pelvic tumors |
| topic | артериальная химиоэмболизация рецидивы рака шейки и тела матки рецидив саркомы матки эмболизация маточных артерий hepasphere остановка кровотечения |
| url | https://ojrs.abvpress.ru/ojrs/article/view/617 |
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