Encapsulation of progesterone-like compounds in 10% liposome increases their concentration in rats administered an injectable dosage form of these compounds
The use of herbal medicine to fill the void in synthetic medicine is very necessary for health lifestyle. Progesterone-like compounds (PLCs) from the extract of the leaves of Dendrophthoe pentandra L. Miq from the subspecies, Benalu Duku (BD), are known to contain beneficial compounds that contain a...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2021-12-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
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| Online Access: | https://vetdergikafkas.org/pdf.php?id=2869 |
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| author | Mochamad LAZUARDI Suharjono SUHARJOMO Chi-Hsien CHIEN Jie-Long HE Chi-Wen LEE Chia-Kang PENG Bambang HERMANTO Mohammad SUKMANADI Rahmi SUGIHARTUTI Lilik MASLACHAH |
| author_facet | Mochamad LAZUARDI Suharjono SUHARJOMO Chi-Hsien CHIEN Jie-Long HE Chi-Wen LEE Chia-Kang PENG Bambang HERMANTO Mohammad SUKMANADI Rahmi SUGIHARTUTI Lilik MASLACHAH |
| author_sort | Mochamad LAZUARDI |
| collection | DOAJ |
| description | The use of herbal medicine to fill the void in synthetic medicine is very necessary for health lifestyle. Progesterone-like compounds (PLCs) from the extract of the leaves of Dendrophthoe pentandra L. Miq from the subspecies, Benalu Duku (BD), are known to contain beneficial compounds that contain anti-cancer and androgenic substances. The slow release of active compounds can be achieved using slow release vehicles. Liposomes that are small unilamellar vesicles (SUVs) are one of the excipient substances that can be reliably used as a vehicle to achieve timely release of bioactive substances. This study was conducted to demonstrate that encapsulating PLCs in 10% liposomal SUV enables the gradual release of bioactive compounds. Three single doses of 3; 5; 7 mg PLCs-Liposome SUV/100 g per body weight of rats were injected into rats in the trial groups (15 of rats). Thereafter, the plasma concentrations of PLCs were assessed using liquid chromatography electrospray ionization mass spectrometry (LC-ESI MS). The concentrations of PLCs in the trial groups were found to be 1.20 to 2.40 fold higher than those in the control group. Such findings indicate that encapsulating drugs in 10% liposomes can result in a higher drug level in blood than that obtained without drug encapsulation (P<0.05). |
| first_indexed | 2024-03-13T04:39:52Z |
| format | Article |
| id | doaj.art-ed4f410c9dab4852bc8f03ce66a6fc74 |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-13T04:39:52Z |
| publishDate | 2021-12-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-ed4f410c9dab4852bc8f03ce66a6fc742023-06-19T06:28:33ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512021-12-01281273410.9775/kvfd.2021.262682869Encapsulation of progesterone-like compounds in 10% liposome increases their concentration in rats administered an injectable dosage form of these compoundsMochamad LAZUARDI0Suharjono SUHARJOMO1Chi-Hsien CHIEN2Jie-Long HE3Chi-Wen LEE4Chia-Kang PENG5Bambang HERMANTO6Mohammad SUKMANADI7Rahmi SUGIHARTUTI8Lilik MASLACHAH9Universitas Airlangga, Faculty of Veterinary Medicine Sub-division Veterinary-Pharmacy, Mulyorejo Rd, 60115, Surabaya, INDONESIAUniversitas Airlangga, Faculty of Pharmacy, Mulyorejo Rd, 60115, Surabaya, INDONESIAAsia University, Departement of Veterinary Medicine, No. 500, Lioufeng Rd., Wufeng District Taichung City, 41354, TAIWANAsia University, Departement of Veterinary Medicine, No. 500, Lioufeng Rd., Wufeng District Taichung City, 41354, TAIWANAsia University, Departement of Veterinary Medicine, No. 500, Lioufeng Rd., Wufeng District Taichung City, 41354, TAIWANAsia University, Departement of Veterinary Medicine, No. 500, Lioufeng Rd., Wufeng District Taichung City, 41354, TAIWANUniversitas Airlangga, Medical Faculty Department Pharmacology, Mayjen Prof. Dr. Moestopo No.47, 60132, Surabaya, INDONESIAUniversitas Airlangga, Faculty of Veterinary Medicine Sub-division Veterinary-Pharmacy, Mulyorejo Rd, 60115, Surabaya, INDONESIAUniversitas Airlangga, Faculty of Veterinary Medicine Sub-division Veterinary-Pharmacy, Mulyorejo Rd, 60115, Surabaya, INDONESIAUniversitas Airlangga, Faculty of Veterinary Medicine Sub-division Veterinary-Pharmacy, Mulyorejo Rd, 60115, Surabaya, INDONESIAThe use of herbal medicine to fill the void in synthetic medicine is very necessary for health lifestyle. Progesterone-like compounds (PLCs) from the extract of the leaves of Dendrophthoe pentandra L. Miq from the subspecies, Benalu Duku (BD), are known to contain beneficial compounds that contain anti-cancer and androgenic substances. The slow release of active compounds can be achieved using slow release vehicles. Liposomes that are small unilamellar vesicles (SUVs) are one of the excipient substances that can be reliably used as a vehicle to achieve timely release of bioactive substances. This study was conducted to demonstrate that encapsulating PLCs in 10% liposomal SUV enables the gradual release of bioactive compounds. Three single doses of 3; 5; 7 mg PLCs-Liposome SUV/100 g per body weight of rats were injected into rats in the trial groups (15 of rats). Thereafter, the plasma concentrations of PLCs were assessed using liquid chromatography electrospray ionization mass spectrometry (LC-ESI MS). The concentrations of PLCs in the trial groups were found to be 1.20 to 2.40 fold higher than those in the control group. Such findings indicate that encapsulating drugs in 10% liposomes can result in a higher drug level in blood than that obtained without drug encapsulation (P<0.05).https://vetdergikafkas.org/pdf.php?id=2869androgenichealth lifestylemistletoe plantprogesterone-like compoundssmall unilamellar vesicle |
| spellingShingle | Mochamad LAZUARDI Suharjono SUHARJOMO Chi-Hsien CHIEN Jie-Long HE Chi-Wen LEE Chia-Kang PENG Bambang HERMANTO Mohammad SUKMANADI Rahmi SUGIHARTUTI Lilik MASLACHAH Encapsulation of progesterone-like compounds in 10% liposome increases their concentration in rats administered an injectable dosage form of these compounds Kafkas Universitesi Veteriner Fakültesi Dergisi androgenic health lifestyle mistletoe plant progesterone-like compounds small unilamellar vesicle |
| title | Encapsulation of progesterone-like compounds in 10% liposome increases their concentration in rats administered an injectable dosage form of these compounds |
| title_full | Encapsulation of progesterone-like compounds in 10% liposome increases their concentration in rats administered an injectable dosage form of these compounds |
| title_fullStr | Encapsulation of progesterone-like compounds in 10% liposome increases their concentration in rats administered an injectable dosage form of these compounds |
| title_full_unstemmed | Encapsulation of progesterone-like compounds in 10% liposome increases their concentration in rats administered an injectable dosage form of these compounds |
| title_short | Encapsulation of progesterone-like compounds in 10% liposome increases their concentration in rats administered an injectable dosage form of these compounds |
| title_sort | encapsulation of progesterone like compounds in 10 liposome increases their concentration in rats administered an injectable dosage form of these compounds |
| topic | androgenic health lifestyle mistletoe plant progesterone-like compounds small unilamellar vesicle |
| url | https://vetdergikafkas.org/pdf.php?id=2869 |
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