Poor glycemic control enhances the disease activity in the RA patients with undiagnosed diabetes—a cross-sectional clinical study
Abstract Background Rheumatoid arthritis (RA), an autoimmune disorder, characterized by systemic inflammation and swollen joints, establishes itself as a critical threat. A pro-inflammatory cytokine TNF-α is a well-known driver of RA pathogenesis and at the same time predisposes to insulin resistanc...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2021-12-01
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| Series: | Egyptian Rheumatology and Rehabilitation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43166-021-00097-8 |
| _version_ | 1798026818880536576 |
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| author | Pulak Kanti Palit Ashekul Islam Md Syeed Al Habib Abu Syed Mohammed Mujib Joyonti Datta Bahni Chakraborty Suman Dhar Dhiman Chowdhury Md Faisal Fahad Chowdhury Mohammad Shawkat Ali Arfana Yesmin Mohammod Johirul Islam Nishat Akther Abdullah Al Mamun Khairul Islam Pradip Kumar Nath |
| author_facet | Pulak Kanti Palit Ashekul Islam Md Syeed Al Habib Abu Syed Mohammed Mujib Joyonti Datta Bahni Chakraborty Suman Dhar Dhiman Chowdhury Md Faisal Fahad Chowdhury Mohammad Shawkat Ali Arfana Yesmin Mohammod Johirul Islam Nishat Akther Abdullah Al Mamun Khairul Islam Pradip Kumar Nath |
| author_sort | Pulak Kanti Palit |
| collection | DOAJ |
| description | Abstract Background Rheumatoid arthritis (RA), an autoimmune disorder, characterized by systemic inflammation and swollen joints, establishes itself as a critical threat. A pro-inflammatory cytokine TNF-α is a well-known driver of RA pathogenesis and at the same time predisposes to insulin resistance through signal impediment which ultimately paves the way for type 2 diabetes (T2DM). However, in patients with RA, T2DM remains significantly undiagnosed or undertreated, apparently which increases the risk of developing cardio-metabolic comorbidities. This study aimed to evaluate the glycemic status among RA patients and its association with disease activity. Result One hundred fifty inpatients RA cases according to ACR/EULAR standards were included in the cross-sectional study who have an average age of 45.4±12.15 years and a median and interquartile period of RA of 2.25 years and 0.48–6 years, respectively. We discovered that 36% of people had T2DM, 26% were prediabetic, and 38% were non-diabetic. Age was shown to be significantly correlated with DM frequency in RA patients (p=0.007). There were 28 patients with elevated disease activity (19%) and 60 patients with low disease activity (40%) in this study. No substantial associations were found in the presence of DM with gender, anti-CCP, RF, disease duration, or DAS28. Conclusion RA patients are more likely to experience diabetes, and resultantly a high index of notion must be kept. Clinician should be aware about the affliction of undiagnosed diabetes and prediabetes in RA patients. Furthermore, keeping an eye on glycemic control in RA patients could prevent metabolic and cardiovascular comorbidities in those susceptible patients. |
| first_indexed | 2024-04-11T18:41:23Z |
| format | Article |
| id | doaj.art-ed4f63cc07ee48f480eba31de6652c62 |
| institution | Directory Open Access Journal |
| issn | 1110-161X 2090-3235 |
| language | English |
| last_indexed | 2024-04-11T18:41:23Z |
| publishDate | 2021-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Rheumatology and Rehabilitation |
| spelling | doaj.art-ed4f63cc07ee48f480eba31de6652c622022-12-22T04:08:58ZengSpringerOpenEgyptian Rheumatology and Rehabilitation1110-161X2090-32352021-12-014811910.1186/s43166-021-00097-8Poor glycemic control enhances the disease activity in the RA patients with undiagnosed diabetes—a cross-sectional clinical studyPulak Kanti Palit0Ashekul Islam1Md Syeed Al Habib2Abu Syed Mohammed Mujib3Joyonti Datta4Bahni Chakraborty5Suman Dhar6Dhiman Chowdhury7Md Faisal Fahad Chowdhury8Mohammad Shawkat Ali9Arfana Yesmin10Mohammod Johirul Islam11Nishat Akther12Abdullah Al Mamun13Khairul Islam14Pradip Kumar Nath15Chittagong Medical CollegeMawlana Bhashani Science and Technology UniversityMawlana Bhashani Science and Technology UniversityUniversity of ChittagongChittagong Medical CollegeChittagong Medical CollegeChittagong Medical CollegeChittagong Medical CollegeChittagong Medical CollegeChittagong Medical CollegeChittagong Medical CollegeMawlana Bhashani Science and Technology UniversityMawlana Bhashani Science and Technology UniversityMawlana Bhashani Science and Technology UniversityMawlana Bhashani Science and Technology UniversityChittagong Medical CollegeAbstract Background Rheumatoid arthritis (RA), an autoimmune disorder, characterized by systemic inflammation and swollen joints, establishes itself as a critical threat. A pro-inflammatory cytokine TNF-α is a well-known driver of RA pathogenesis and at the same time predisposes to insulin resistance through signal impediment which ultimately paves the way for type 2 diabetes (T2DM). However, in patients with RA, T2DM remains significantly undiagnosed or undertreated, apparently which increases the risk of developing cardio-metabolic comorbidities. This study aimed to evaluate the glycemic status among RA patients and its association with disease activity. Result One hundred fifty inpatients RA cases according to ACR/EULAR standards were included in the cross-sectional study who have an average age of 45.4±12.15 years and a median and interquartile period of RA of 2.25 years and 0.48–6 years, respectively. We discovered that 36% of people had T2DM, 26% were prediabetic, and 38% were non-diabetic. Age was shown to be significantly correlated with DM frequency in RA patients (p=0.007). There were 28 patients with elevated disease activity (19%) and 60 patients with low disease activity (40%) in this study. No substantial associations were found in the presence of DM with gender, anti-CCP, RF, disease duration, or DAS28. Conclusion RA patients are more likely to experience diabetes, and resultantly a high index of notion must be kept. Clinician should be aware about the affliction of undiagnosed diabetes and prediabetes in RA patients. Furthermore, keeping an eye on glycemic control in RA patients could prevent metabolic and cardiovascular comorbidities in those susceptible patients.https://doi.org/10.1186/s43166-021-00097-8Diabetes mellitusRheumatoid arthritisGlycemic controlDAS-28RFAnti-CCP |
| spellingShingle | Pulak Kanti Palit Ashekul Islam Md Syeed Al Habib Abu Syed Mohammed Mujib Joyonti Datta Bahni Chakraborty Suman Dhar Dhiman Chowdhury Md Faisal Fahad Chowdhury Mohammad Shawkat Ali Arfana Yesmin Mohammod Johirul Islam Nishat Akther Abdullah Al Mamun Khairul Islam Pradip Kumar Nath Poor glycemic control enhances the disease activity in the RA patients with undiagnosed diabetes—a cross-sectional clinical study Egyptian Rheumatology and Rehabilitation Diabetes mellitus Rheumatoid arthritis Glycemic control DAS-28 RF Anti-CCP |
| title | Poor glycemic control enhances the disease activity in the RA patients with undiagnosed diabetes—a cross-sectional clinical study |
| title_full | Poor glycemic control enhances the disease activity in the RA patients with undiagnosed diabetes—a cross-sectional clinical study |
| title_fullStr | Poor glycemic control enhances the disease activity in the RA patients with undiagnosed diabetes—a cross-sectional clinical study |
| title_full_unstemmed | Poor glycemic control enhances the disease activity in the RA patients with undiagnosed diabetes—a cross-sectional clinical study |
| title_short | Poor glycemic control enhances the disease activity in the RA patients with undiagnosed diabetes—a cross-sectional clinical study |
| title_sort | poor glycemic control enhances the disease activity in the ra patients with undiagnosed diabetes a cross sectional clinical study |
| topic | Diabetes mellitus Rheumatoid arthritis Glycemic control DAS-28 RF Anti-CCP |
| url | https://doi.org/10.1186/s43166-021-00097-8 |
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