The limits of test-based scrapie eradication programs in goats.
Small ruminant post-mortem testing programs were initially designed for monitoring the prevalence of prion disease. They are now considered as a potential alternative to genetic selection for eradicating/controlling classical scrapie at population level. If such policy should be implemented, its suc...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3553010?pdf=render |
| _version_ | 1819041880508203008 |
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| author | Fabien Corbière Cécile Chauvineau-Perrin Caroline Lacroux Séverine Lugan Pierrette Costes Myriam Thomas Isabelle Brémaud Christophe Chartier Francis Barillet François Schelcher Olivier Andréoletti |
| author_facet | Fabien Corbière Cécile Chauvineau-Perrin Caroline Lacroux Séverine Lugan Pierrette Costes Myriam Thomas Isabelle Brémaud Christophe Chartier Francis Barillet François Schelcher Olivier Andréoletti |
| author_sort | Fabien Corbière |
| collection | DOAJ |
| description | Small ruminant post-mortem testing programs were initially designed for monitoring the prevalence of prion disease. They are now considered as a potential alternative to genetic selection for eradicating/controlling classical scrapie at population level. If such policy should be implemented, its success would be crucially dependent on the efficiency of the surveillance system used to identify infected flocks. In this study, we first determined the performance of post-mortem classical scrapie detection in eight naturally affected goat herds (total n = 1961 animals) according to the age at culling. These results provided us with necessary parameters to estimate, through a Monte Carlo simulation model, the performance of scrapie detection in a commercial population. According to this model, whatever the number of tests performed, post mortem surveillance will have limited success in identifying infected herds. These data support the contention that scrapie eradication programs relying solely on post mortem testing in goats will probably fail. Considering the epidemiological and pathological similarities of scrapie in sheep and goats, the efficiency of scrapie surveillance in both species is likely to be similar. |
| first_indexed | 2024-12-21T09:32:01Z |
| format | Article |
| id | doaj.art-ed5110fc332e4fd49f8da1cf5a05d3c8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T09:32:01Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ed5110fc332e4fd49f8da1cf5a05d3c82022-12-21T19:08:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5491110.1371/journal.pone.0054911The limits of test-based scrapie eradication programs in goats.Fabien CorbièreCécile Chauvineau-PerrinCaroline LacrouxSéverine LuganPierrette CostesMyriam ThomasIsabelle BrémaudChristophe ChartierFrancis BarilletFrançois SchelcherOlivier AndréolettiSmall ruminant post-mortem testing programs were initially designed for monitoring the prevalence of prion disease. They are now considered as a potential alternative to genetic selection for eradicating/controlling classical scrapie at population level. If such policy should be implemented, its success would be crucially dependent on the efficiency of the surveillance system used to identify infected flocks. In this study, we first determined the performance of post-mortem classical scrapie detection in eight naturally affected goat herds (total n = 1961 animals) according to the age at culling. These results provided us with necessary parameters to estimate, through a Monte Carlo simulation model, the performance of scrapie detection in a commercial population. According to this model, whatever the number of tests performed, post mortem surveillance will have limited success in identifying infected herds. These data support the contention that scrapie eradication programs relying solely on post mortem testing in goats will probably fail. Considering the epidemiological and pathological similarities of scrapie in sheep and goats, the efficiency of scrapie surveillance in both species is likely to be similar.http://europepmc.org/articles/PMC3553010?pdf=render |
| spellingShingle | Fabien Corbière Cécile Chauvineau-Perrin Caroline Lacroux Séverine Lugan Pierrette Costes Myriam Thomas Isabelle Brémaud Christophe Chartier Francis Barillet François Schelcher Olivier Andréoletti The limits of test-based scrapie eradication programs in goats. PLoS ONE |
| title | The limits of test-based scrapie eradication programs in goats. |
| title_full | The limits of test-based scrapie eradication programs in goats. |
| title_fullStr | The limits of test-based scrapie eradication programs in goats. |
| title_full_unstemmed | The limits of test-based scrapie eradication programs in goats. |
| title_short | The limits of test-based scrapie eradication programs in goats. |
| title_sort | limits of test based scrapie eradication programs in goats |
| url | http://europepmc.org/articles/PMC3553010?pdf=render |
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