Catechol-chitosan/polyacrylamide hydrogel wound dressing for regulating local inflammation
Chronic wounds and the accompanying inflammation are ongoing challenges in clinical treatment. They are usually accompanied by low pH and high oxidative stress environments, limiting cell growth and proliferation. Ordinary medical gauze has limited therapeutic effects on chronic wounds, and there is...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
|
| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422001909 |
| _version_ | 1797990826128703488 |
|---|---|
| author | Bingyang Lu Xiao Han Dan Zou Xiao Luo Li Liu Jingyue Wang Manfred F. Maitz Ping Yang Nan Huang Ansha Zhao |
| author_facet | Bingyang Lu Xiao Han Dan Zou Xiao Luo Li Liu Jingyue Wang Manfred F. Maitz Ping Yang Nan Huang Ansha Zhao |
| author_sort | Bingyang Lu |
| collection | DOAJ |
| description | Chronic wounds and the accompanying inflammation are ongoing challenges in clinical treatment. They are usually accompanied by low pH and high oxidative stress environments, limiting cell growth and proliferation. Ordinary medical gauze has limited therapeutic effects on chronic wounds, and there is active research to develop new wound dressings. The chitosan hydrogel could be widely used in biomedical science with great biocompatibility, but the low mechanical properties limit its development. This work uses polyacrylamide to prepare double-network (DN) hydrogels based on bioadhesive catechol-chitosan hydrogels. Cystamine and N, N′-Bis(acryloyl)cystamine, which can be cross-linking agents with disulfide bonds to prepare redox-responsive DN hydrogels and pH-responsive nanoparticles (NPs) prepared by acetalized cyclodextrin (ACD) are used to intelligently release drugs against chronic inflammation microenvironments. The addition of catechol groups and ACD-NPs loaded with the Resolvin E1 (RvE1), promotes cell adhesion and regulates the inflammatory response at the wound site. The preparation of the DN hydrogel in this study can be used to treat and regulate the inflammatory microenvironment of chronic wounds accurately. It provides new ideas for using inflammation resolving factor loaded in DN hydrogel of good biocompatibility with enhanced mechanical properties to intelligent regulate the wound inflammation and promote the wound repaired. |
| first_indexed | 2024-04-11T08:42:36Z |
| format | Article |
| id | doaj.art-ed5140d0a54b4fd1936297c2f353d815 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-11T08:42:36Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-ed5140d0a54b4fd1936297c2f353d8152022-12-22T04:34:11ZengElsevierMaterials Today Bio2590-00642022-12-0116100392Catechol-chitosan/polyacrylamide hydrogel wound dressing for regulating local inflammationBingyang Lu0Xiao Han1Dan Zou2Xiao Luo3Li Liu4Jingyue Wang5Manfred F. Maitz6Ping Yang7Nan Huang8Ansha Zhao9Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, ChinaLeibniz-Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden, Hohe Strasse 6, 01069, Dresden, GermanyKey Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, ChinaKey Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China; Corresponding author. Key Lab. for Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.Chronic wounds and the accompanying inflammation are ongoing challenges in clinical treatment. They are usually accompanied by low pH and high oxidative stress environments, limiting cell growth and proliferation. Ordinary medical gauze has limited therapeutic effects on chronic wounds, and there is active research to develop new wound dressings. The chitosan hydrogel could be widely used in biomedical science with great biocompatibility, but the low mechanical properties limit its development. This work uses polyacrylamide to prepare double-network (DN) hydrogels based on bioadhesive catechol-chitosan hydrogels. Cystamine and N, N′-Bis(acryloyl)cystamine, which can be cross-linking agents with disulfide bonds to prepare redox-responsive DN hydrogels and pH-responsive nanoparticles (NPs) prepared by acetalized cyclodextrin (ACD) are used to intelligently release drugs against chronic inflammation microenvironments. The addition of catechol groups and ACD-NPs loaded with the Resolvin E1 (RvE1), promotes cell adhesion and regulates the inflammatory response at the wound site. The preparation of the DN hydrogel in this study can be used to treat and regulate the inflammatory microenvironment of chronic wounds accurately. It provides new ideas for using inflammation resolving factor loaded in DN hydrogel of good biocompatibility with enhanced mechanical properties to intelligent regulate the wound inflammation and promote the wound repaired.http://www.sciencedirect.com/science/article/pii/S2590006422001909pH and redox responsiveResolvinDrug deliveryDouble network hydrogelChronic wounds and inflammation |
| spellingShingle | Bingyang Lu Xiao Han Dan Zou Xiao Luo Li Liu Jingyue Wang Manfred F. Maitz Ping Yang Nan Huang Ansha Zhao Catechol-chitosan/polyacrylamide hydrogel wound dressing for regulating local inflammation Materials Today Bio pH and redox responsive Resolvin Drug delivery Double network hydrogel Chronic wounds and inflammation |
| title | Catechol-chitosan/polyacrylamide hydrogel wound dressing for regulating local inflammation |
| title_full | Catechol-chitosan/polyacrylamide hydrogel wound dressing for regulating local inflammation |
| title_fullStr | Catechol-chitosan/polyacrylamide hydrogel wound dressing for regulating local inflammation |
| title_full_unstemmed | Catechol-chitosan/polyacrylamide hydrogel wound dressing for regulating local inflammation |
| title_short | Catechol-chitosan/polyacrylamide hydrogel wound dressing for regulating local inflammation |
| title_sort | catechol chitosan polyacrylamide hydrogel wound dressing for regulating local inflammation |
| topic | pH and redox responsive Resolvin Drug delivery Double network hydrogel Chronic wounds and inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422001909 |
| work_keys_str_mv | AT bingyanglu catecholchitosanpolyacrylamidehydrogelwounddressingforregulatinglocalinflammation AT xiaohan catecholchitosanpolyacrylamidehydrogelwounddressingforregulatinglocalinflammation AT danzou catecholchitosanpolyacrylamidehydrogelwounddressingforregulatinglocalinflammation AT xiaoluo catecholchitosanpolyacrylamidehydrogelwounddressingforregulatinglocalinflammation AT liliu catecholchitosanpolyacrylamidehydrogelwounddressingforregulatinglocalinflammation AT jingyuewang catecholchitosanpolyacrylamidehydrogelwounddressingforregulatinglocalinflammation AT manfredfmaitz catecholchitosanpolyacrylamidehydrogelwounddressingforregulatinglocalinflammation AT pingyang catecholchitosanpolyacrylamidehydrogelwounddressingforregulatinglocalinflammation AT nanhuang catecholchitosanpolyacrylamidehydrogelwounddressingforregulatinglocalinflammation AT anshazhao catecholchitosanpolyacrylamidehydrogelwounddressingforregulatinglocalinflammation |