Bifunctional antibiotic hybrids: A review of clinical candidates
Antibiotic resistance is a top threat to human health and a priority across the globe. This problematic issue is accompanied by the decline of new antibiotics in the pipeline over the past 30 years. In this context, an urgent need to develop new strategies to combat antimicrobial resistance is in gr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1158152/full |
| _version_ | 1797802414435205120 |
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| author | Augustine Jing Jie Koh Varsha Thombare Maytham Hussein Gauri G. Rao Jian Li Tony Velkov Tony Velkov |
| author_facet | Augustine Jing Jie Koh Varsha Thombare Maytham Hussein Gauri G. Rao Jian Li Tony Velkov Tony Velkov |
| author_sort | Augustine Jing Jie Koh |
| collection | DOAJ |
| description | Antibiotic resistance is a top threat to human health and a priority across the globe. This problematic issue is accompanied by the decline of new antibiotics in the pipeline over the past 30 years. In this context, an urgent need to develop new strategies to combat antimicrobial resistance is in great demand. Lately, among the possible approaches used to deal with antimicrobial resistance is the covalent ligation of two antibiotic pharmacophores that target the bacterial cells through a dissimilar mode of action into a single hybrid molecule, namely hybrid antibiotics. This strategy exhibits several advantages, including better antibacterial activity, overcoming the existing resistance towards individual antibiotics, and may ultimately delay the onset of bacterial resistance. This review sheds light on the latest development of the dual antibiotic hybrids pipeline, their potential mechanisms of action, and challenges in their use. |
| first_indexed | 2024-03-13T05:05:20Z |
| format | Article |
| id | doaj.art-ed517d4f7d70407991ecf69ae72cf14d |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-13T05:05:20Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-ed517d4f7d70407991ecf69ae72cf14d2023-06-16T16:56:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-06-011410.3389/fphar.2023.11581521158152Bifunctional antibiotic hybrids: A review of clinical candidatesAugustine Jing Jie Koh0Varsha Thombare1Maytham Hussein2Gauri G. Rao3Jian Li4Tony Velkov5Tony Velkov6Department of Biochemistry and Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIP, AustraliaMonash Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Parkville, VIP, AustraliaMonash Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Parkville, VIP, AustraliaDivision of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, United StatesMonash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Parkville, VIP, AustraliaDepartment of Biochemistry and Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIP, AustraliaMonash Biomedicine Discovery Institute, Department of Pharmacology, Monash University, Parkville, VIP, AustraliaAntibiotic resistance is a top threat to human health and a priority across the globe. This problematic issue is accompanied by the decline of new antibiotics in the pipeline over the past 30 years. In this context, an urgent need to develop new strategies to combat antimicrobial resistance is in great demand. Lately, among the possible approaches used to deal with antimicrobial resistance is the covalent ligation of two antibiotic pharmacophores that target the bacterial cells through a dissimilar mode of action into a single hybrid molecule, namely hybrid antibiotics. This strategy exhibits several advantages, including better antibacterial activity, overcoming the existing resistance towards individual antibiotics, and may ultimately delay the onset of bacterial resistance. This review sheds light on the latest development of the dual antibiotic hybrids pipeline, their potential mechanisms of action, and challenges in their use.https://www.frontiersin.org/articles/10.3389/fphar.2023.1158152/fullantibiotic resistancedrug combinationshybrid antibioticsantibiotic pipelinedrug synthesis |
| spellingShingle | Augustine Jing Jie Koh Varsha Thombare Maytham Hussein Gauri G. Rao Jian Li Tony Velkov Tony Velkov Bifunctional antibiotic hybrids: A review of clinical candidates Frontiers in Pharmacology antibiotic resistance drug combinations hybrid antibiotics antibiotic pipeline drug synthesis |
| title | Bifunctional antibiotic hybrids: A review of clinical candidates |
| title_full | Bifunctional antibiotic hybrids: A review of clinical candidates |
| title_fullStr | Bifunctional antibiotic hybrids: A review of clinical candidates |
| title_full_unstemmed | Bifunctional antibiotic hybrids: A review of clinical candidates |
| title_short | Bifunctional antibiotic hybrids: A review of clinical candidates |
| title_sort | bifunctional antibiotic hybrids a review of clinical candidates |
| topic | antibiotic resistance drug combinations hybrid antibiotics antibiotic pipeline drug synthesis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1158152/full |
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