Adenine: an important drug scaffold for the design of antiviral agents

Adenine: an important drug scaffold for the design of antiviral agents

Adenine derivatives, in particular the scaffold bearing the acyclic nucleoside phosphonates (ANPS), possess significant antiviral and cytostatic activity. Till now, several effective adenine derivatives have been marketed for the treatment of HIV, HBV, CMV and other virus-infected diseases. These co...

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Bibliographic Details
Main Authors: Changyuan Wang, Zhendong Song, Haiqing Yu, Kexin Liu, Xiaodong Ma
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Antiviral
Structure–activity relationship
Adenine
Acyclic nucleoside phosphonates
Scaffold
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383515001057

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