Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell
Pyramidal neurons, a mainstay of cortical regions, receive a plethora of inputs from various areas onto their morphologically distinct apical and basal trees. Both trees differentially contribute to the somatic response, defining distinct anatomical and possibly functional sub-units. To elucidate th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2023-12-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/91627 |
| _version_ | 1797373714922209280 |
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| author | Konstantinos-Evangelos Petousakis Jiyoung Park Athanasia Papoutsi Stelios Smirnakis Panayiota Poirazi |
| author_facet | Konstantinos-Evangelos Petousakis Jiyoung Park Athanasia Papoutsi Stelios Smirnakis Panayiota Poirazi |
| author_sort | Konstantinos-Evangelos Petousakis |
| collection | DOAJ |
| description | Pyramidal neurons, a mainstay of cortical regions, receive a plethora of inputs from various areas onto their morphologically distinct apical and basal trees. Both trees differentially contribute to the somatic response, defining distinct anatomical and possibly functional sub-units. To elucidate the contribution of each tree to the encoding of visual stimuli at the somatic level, we modeled the response pattern of a mouse L2/3 V1 pyramidal neuron to orientation tuned synaptic input. Towards this goal, we used a morphologically detailed computational model of a single cell that replicates electrophysiological and two-photon imaging data. Our simulations predict a synergistic effect of apical and basal trees on somatic action potential generation: basal tree activity, in the form of either depolarization or dendritic spiking, is necessary for producing somatic activity, despite the fact that most somatic spikes are heavily driven by apical dendritic spikes. This model provides evidence for synergistic computations taking place in the basal and apical trees of the L2/3 V1 neuron along with mechanistic explanations for tree-specific contributions and emphasizes the potential role of predictive and attentional feedback input in these cells. |
| first_indexed | 2024-03-08T18:54:26Z |
| format | Article |
| id | doaj.art-ed51f923562f451e918482b23e593d42 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-03-08T18:54:26Z |
| publishDate | 2023-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-ed51f923562f451e918482b23e593d422023-12-28T15:29:33ZengeLife Sciences Publications LtdeLife2050-084X2023-12-011210.7554/eLife.91627Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cellKonstantinos-Evangelos Petousakis0https://orcid.org/0000-0003-2022-1671Jiyoung Park1Athanasia Papoutsi2https://orcid.org/0000-0003-2466-7259Stelios Smirnakis3https://orcid.org/0000-0002-1929-2811Panayiota Poirazi4https://orcid.org/0000-0001-6152-595XDepartment of Biology, University of Crete, Heraklion, Greece; IMBB, FORTH, Heraklion, GreeceDepartment of Neurology, Brigham and Women’s Hospital and Jamaica Plain Veterans Administration Hospital, Harvard Medical School, Boston, United StatesIMBB, FORTH, Heraklion, GreeceDepartment of Neurology, Brigham and Women’s Hospital and Jamaica Plain Veterans Administration Hospital, Harvard Medical School, Boston, United StatesIMBB, FORTH, Heraklion, GreecePyramidal neurons, a mainstay of cortical regions, receive a plethora of inputs from various areas onto their morphologically distinct apical and basal trees. Both trees differentially contribute to the somatic response, defining distinct anatomical and possibly functional sub-units. To elucidate the contribution of each tree to the encoding of visual stimuli at the somatic level, we modeled the response pattern of a mouse L2/3 V1 pyramidal neuron to orientation tuned synaptic input. Towards this goal, we used a morphologically detailed computational model of a single cell that replicates electrophysiological and two-photon imaging data. Our simulations predict a synergistic effect of apical and basal trees on somatic action potential generation: basal tree activity, in the form of either depolarization or dendritic spiking, is necessary for producing somatic activity, despite the fact that most somatic spikes are heavily driven by apical dendritic spikes. This model provides evidence for synergistic computations taking place in the basal and apical trees of the L2/3 V1 neuron along with mechanistic explanations for tree-specific contributions and emphasizes the potential role of predictive and attentional feedback input in these cells.https://elifesciences.org/articles/91627V1pyramidal neuron modeldendritesapical treebasal treeL 2/3 |
| spellingShingle | Konstantinos-Evangelos Petousakis Jiyoung Park Athanasia Papoutsi Stelios Smirnakis Panayiota Poirazi Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell eLife V1 pyramidal neuron model dendrites apical tree basal tree L 2/3 |
| title | Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell |
| title_full | Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell |
| title_fullStr | Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell |
| title_full_unstemmed | Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell |
| title_short | Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell |
| title_sort | modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2 3 pyramidal cell |
| topic | V1 pyramidal neuron model dendrites apical tree basal tree L 2/3 |
| url | https://elifesciences.org/articles/91627 |
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