The oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi
Abstract Background Psoroptes cuniculi can parasitise the ear canal of the rabbit, and cause the afflicted animals to cease feeding and become severely debilitated, sometimes resulting in death. In this study, we examined the oxidative status and inflammatory level of the peripheral blood of rabbits...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2014-03-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/1756-3305-7-124 |
| _version_ | 1797811722166206464 |
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| author | Xiaofei Shang Dongsheng Wang Xiaolou Miao Xuezhi Wang Jianxi Li Zhiqiang Yang Hu Pan |
| author_facet | Xiaofei Shang Dongsheng Wang Xiaolou Miao Xuezhi Wang Jianxi Li Zhiqiang Yang Hu Pan |
| author_sort | Xiaofei Shang |
| collection | DOAJ |
| description | Abstract Background Psoroptes cuniculi can parasitise the ear canal of the rabbit, and cause the afflicted animals to cease feeding and become severely debilitated, sometimes resulting in death. In this study, we examined the oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi and investigated the pathogenesis of this disease. Methods A total of 24 rabbits were divided into a healthy rabbit group and two infested rabbit groups. After weighing the rabbits, approximately 5 ml of blood was obtained from each animal. Then, the blood serum was extracted and used to assess the levels of antioxidant enzymes and inflammatory factors. Results Compared to the healthy rabbits, the activities of catalase and glutathione-S-transferase and the level of malonyldialdehyde were increased, but the activity of superoxide dismutase was reduced in the infested rabbits. At the same time, a variety of inflammatory cells were activated, and the levels of inflammatory factors such as prostaglandin E2, interleukin-6, interleukin-8 and transforming growth factor-β1 were increased in peripheral blood. Conclusion Animal acariasis was associated with immunosuppressive disorders and inflammatory reaction. These results advance our understanding of the pathogenesis of Psoroptes cuniculi infestation in rabbits and can help guide the effectual treatment of this disease in clinics. |
| first_indexed | 2024-03-13T07:26:54Z |
| format | Article |
| id | doaj.art-ed5425471aaf47768a65de78aaeab4c1 |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-03-13T07:26:54Z |
| publishDate | 2014-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-ed5425471aaf47768a65de78aaeab4c12023-06-04T11:19:47ZengBMCParasites & Vectors1756-33052014-03-01711610.1186/1756-3305-7-124The oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculiXiaofei Shang0Dongsheng Wang1Xiaolou Miao2Xuezhi Wang3Jianxi Li4Zhiqiang Yang5Hu Pan6Key Lab of New Animal Drug ProjectKey Lab of New Animal Drug ProjectKey Lab of New Animal Drug ProjectKey Lab of New Animal Drug ProjectKey Lab of New Animal Drug ProjectKey Lab of New Animal Drug ProjectKey Lab of New Animal Drug ProjectAbstract Background Psoroptes cuniculi can parasitise the ear canal of the rabbit, and cause the afflicted animals to cease feeding and become severely debilitated, sometimes resulting in death. In this study, we examined the oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi and investigated the pathogenesis of this disease. Methods A total of 24 rabbits were divided into a healthy rabbit group and two infested rabbit groups. After weighing the rabbits, approximately 5 ml of blood was obtained from each animal. Then, the blood serum was extracted and used to assess the levels of antioxidant enzymes and inflammatory factors. Results Compared to the healthy rabbits, the activities of catalase and glutathione-S-transferase and the level of malonyldialdehyde were increased, but the activity of superoxide dismutase was reduced in the infested rabbits. At the same time, a variety of inflammatory cells were activated, and the levels of inflammatory factors such as prostaglandin E2, interleukin-6, interleukin-8 and transforming growth factor-β1 were increased in peripheral blood. Conclusion Animal acariasis was associated with immunosuppressive disorders and inflammatory reaction. These results advance our understanding of the pathogenesis of Psoroptes cuniculi infestation in rabbits and can help guide the effectual treatment of this disease in clinics.https://doi.org/10.1186/1756-3305-7-124RabbitsPsoroptes cuniculiOxidative statusSuperoxide dismutaseInflammatory factor |
| spellingShingle | Xiaofei Shang Dongsheng Wang Xiaolou Miao Xuezhi Wang Jianxi Li Zhiqiang Yang Hu Pan The oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi Parasites & Vectors Rabbits Psoroptes cuniculi Oxidative status Superoxide dismutase Inflammatory factor |
| title | The oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi |
| title_full | The oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi |
| title_fullStr | The oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi |
| title_full_unstemmed | The oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi |
| title_short | The oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi |
| title_sort | oxidative status and inflammatory level of the peripheral blood of rabbits infested with psoroptes cuniculi |
| topic | Rabbits Psoroptes cuniculi Oxidative status Superoxide dismutase Inflammatory factor |
| url | https://doi.org/10.1186/1756-3305-7-124 |
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