Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation
Abstract Background Over the years, the scope of outcomes assessment in chronic obstructive pulmonary disease (COPD) has broadened, allowing for the evaluation of various patient-reported outcomes (PROs). As it still remains unclear whether and to what extent PROs mirror the exercise performance of...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-09-01
|
| Series: | Health and Quality of Life Outcomes |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12955-020-01505-x |
| _version_ | 1818506916447387648 |
|---|---|
| author | Roy Meys Anouk A. F. Stoffels Sarah Houben-Wilke Daisy J. A. Janssen Chris Burtin Hieronymus W. H. van Hees Frits M. E. Franssen Bram van den Borst Emiel F. M. Wouters Martijn A. Spruit on behalf of the BASES-consortium |
| author_facet | Roy Meys Anouk A. F. Stoffels Sarah Houben-Wilke Daisy J. A. Janssen Chris Burtin Hieronymus W. H. van Hees Frits M. E. Franssen Bram van den Borst Emiel F. M. Wouters Martijn A. Spruit on behalf of the BASES-consortium |
| author_sort | Roy Meys |
| collection | DOAJ |
| description | Abstract Background Over the years, the scope of outcomes assessment in chronic obstructive pulmonary disease (COPD) has broadened, allowing for the evaluation of various patient-reported outcomes (PROs). As it still remains unclear whether and to what extent PROs mirror the exercise performance of patients with COPD, the current study aimed to assess the association between different exercise test outcomes and PROs, before and after pulmonary rehabilitation (PR). Methods Correlations between PROs used to describe health-related quality of life (HRQoL), mood status, level of care dependency and dyspnea in patients with COPD and commonly used laboratory- and field-based exercise test outcomes were evaluated in 518 individuals with COPD attending PR. Results Overall, correlations between PROs and exercise test outcomes at baseline were statistically significant. The correlation between modified Medical Research Council (mMRC) dyspnea score and 6-min walking distance (6MWD) was strongest (ρ:-0.65; p<0.001). HRQoL related PROs showed weak correlations with exercise outcomes at baseline. Moderate correlations were found between St George’s Respiratory Questionnaire total score and 6MWD (r:-0.53; p<0.001) and maximal workload achieved during cardiopulmonary exercise testing (ρ:-0.48; p<0.001); and between Clinical COPD Questionnaire (CCQ) total score and 6MWD (r:-0.48; p<0.001) and maximal workload (ρ:-0.43; p<0.001). When significant, correlations between changes in exercise test outcomes and changes in PROs after PR were generally very weak or weak. The highest correlation was found between changes in CCQ total score and changes in 6MWD (ρ: − 0.36; p<0.001). Conclusions PROs and exercise test outcomes, although significantly correlated with each other, assess different disease features in patients with COPD. Individual PROs need to be supported by additional functional measurements whenever possible, in order to get a more detailed insight in the effectiveness of a PR program. Trial registration Netherlands Trial Register ( NL3263 /NTR3416). Registered 2 May 2012. |
| first_indexed | 2024-12-10T22:11:11Z |
| format | Article |
| id | doaj.art-ed54e0dc8a764e669729f49f0639edff |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-12-10T22:11:11Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-ed54e0dc8a764e669729f49f0639edff2022-12-22T01:31:37ZengBMCHealth and Quality of Life Outcomes1477-75252020-09-011811910.1186/s12955-020-01505-xAssociation between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitationRoy Meys0Anouk A. F. Stoffels1Sarah Houben-Wilke2Daisy J. A. Janssen3Chris Burtin4Hieronymus W. H. van Hees5Frits M. E. Franssen6Bram van den Borst7Emiel F. M. Wouters8Martijn A. Spruit9on behalf of the BASES-consortiumDepartment of Research and Development, CIRODepartment of Research and Development, CIRODepartment of Research and Development, CIRODepartment of Research and Development, CIROReval Rehabilitation Research, Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt UniversityDepartment of Pulmonary Diseases, Radboud UMC DekkerswaldDepartment of Research and Development, CIRODepartment of Pulmonary Diseases, Radboud UMC DekkerswaldDepartment of Research and Development, CIRODepartment of Research and Development, CIROAbstract Background Over the years, the scope of outcomes assessment in chronic obstructive pulmonary disease (COPD) has broadened, allowing for the evaluation of various patient-reported outcomes (PROs). As it still remains unclear whether and to what extent PROs mirror the exercise performance of patients with COPD, the current study aimed to assess the association between different exercise test outcomes and PROs, before and after pulmonary rehabilitation (PR). Methods Correlations between PROs used to describe health-related quality of life (HRQoL), mood status, level of care dependency and dyspnea in patients with COPD and commonly used laboratory- and field-based exercise test outcomes were evaluated in 518 individuals with COPD attending PR. Results Overall, correlations between PROs and exercise test outcomes at baseline were statistically significant. The correlation between modified Medical Research Council (mMRC) dyspnea score and 6-min walking distance (6MWD) was strongest (ρ:-0.65; p<0.001). HRQoL related PROs showed weak correlations with exercise outcomes at baseline. Moderate correlations were found between St George’s Respiratory Questionnaire total score and 6MWD (r:-0.53; p<0.001) and maximal workload achieved during cardiopulmonary exercise testing (ρ:-0.48; p<0.001); and between Clinical COPD Questionnaire (CCQ) total score and 6MWD (r:-0.48; p<0.001) and maximal workload (ρ:-0.43; p<0.001). When significant, correlations between changes in exercise test outcomes and changes in PROs after PR were generally very weak or weak. The highest correlation was found between changes in CCQ total score and changes in 6MWD (ρ: − 0.36; p<0.001). Conclusions PROs and exercise test outcomes, although significantly correlated with each other, assess different disease features in patients with COPD. Individual PROs need to be supported by additional functional measurements whenever possible, in order to get a more detailed insight in the effectiveness of a PR program. Trial registration Netherlands Trial Register ( NL3263 /NTR3416). Registered 2 May 2012.http://link.springer.com/article/10.1186/s12955-020-01505-xCOPDPatient-reported outcome measuresExercise testPulmonary rehabilitationQuality of life |
| spellingShingle | Roy Meys Anouk A. F. Stoffels Sarah Houben-Wilke Daisy J. A. Janssen Chris Burtin Hieronymus W. H. van Hees Frits M. E. Franssen Bram van den Borst Emiel F. M. Wouters Martijn A. Spruit on behalf of the BASES-consortium Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation Health and Quality of Life Outcomes COPD Patient-reported outcome measures Exercise test Pulmonary rehabilitation Quality of life |
| title | Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation |
| title_full | Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation |
| title_fullStr | Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation |
| title_full_unstemmed | Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation |
| title_short | Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation |
| title_sort | association between patient reported outcomes and exercise test outcomes in patients with copd before and after pulmonary rehabilitation |
| topic | COPD Patient-reported outcome measures Exercise test Pulmonary rehabilitation Quality of life |
| url | http://link.springer.com/article/10.1186/s12955-020-01505-x |
| work_keys_str_mv | AT roymeys associationbetweenpatientreportedoutcomesandexercisetestoutcomesinpatientswithcopdbeforeandafterpulmonaryrehabilitation AT anoukafstoffels associationbetweenpatientreportedoutcomesandexercisetestoutcomesinpatientswithcopdbeforeandafterpulmonaryrehabilitation AT sarahhoubenwilke associationbetweenpatientreportedoutcomesandexercisetestoutcomesinpatientswithcopdbeforeandafterpulmonaryrehabilitation AT daisyjajanssen associationbetweenpatientreportedoutcomesandexercisetestoutcomesinpatientswithcopdbeforeandafterpulmonaryrehabilitation AT chrisburtin associationbetweenpatientreportedoutcomesandexercisetestoutcomesinpatientswithcopdbeforeandafterpulmonaryrehabilitation AT hieronymuswhvanhees associationbetweenpatientreportedoutcomesandexercisetestoutcomesinpatientswithcopdbeforeandafterpulmonaryrehabilitation AT fritsmefranssen associationbetweenpatientreportedoutcomesandexercisetestoutcomesinpatientswithcopdbeforeandafterpulmonaryrehabilitation AT bramvandenborst associationbetweenpatientreportedoutcomesandexercisetestoutcomesinpatientswithcopdbeforeandafterpulmonaryrehabilitation AT emielfmwouters associationbetweenpatientreportedoutcomesandexercisetestoutcomesinpatientswithcopdbeforeandafterpulmonaryrehabilitation AT martijnaspruit associationbetweenpatientreportedoutcomesandexercisetestoutcomesinpatientswithcopdbeforeandafterpulmonaryrehabilitation AT onbehalfofthebasesconsortium associationbetweenpatientreportedoutcomesandexercisetestoutcomesinpatientswithcopdbeforeandafterpulmonaryrehabilitation |