Reverse Remodeling and Functional Improvement of Left Ventricle in Patients with Chronic Heart Failure Treated with Sacubitril/Valsartan: Comparison between Non-Ischemic and Ischemic Etiology
Sacubitril/valsartan (SV) has been demonstrated to reduce cardiovascular mortality, hospitalization for heart failure and to induce reverse ventricular remodeling. The present study was designed to confirm the effects of SV in a selected population of patients with HFrEF and to evaluate the differen...
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MDPI AG
2023-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/2/621 |
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| author | Roberto Cemin Simona Casablanca Luisa Foco Elisabeth Schoepf Andrea Erlicher Renato Di Gaetano Davide Ermacora |
| author_facet | Roberto Cemin Simona Casablanca Luisa Foco Elisabeth Schoepf Andrea Erlicher Renato Di Gaetano Davide Ermacora |
| author_sort | Roberto Cemin |
| collection | DOAJ |
| description | Sacubitril/valsartan (SV) has been demonstrated to reduce cardiovascular mortality, hospitalization for heart failure and to induce reverse ventricular remodeling. The present study was designed to confirm the effects of SV in a selected population of patients with HFrEF and to evaluate the different responses between patients with an ischemic or a non-ischemic etiology. A total of 79 patients with indication of SV were recruited prospectively during a timelapse of 4 years. SV was overall associated to a reduction of end-diastolic and end-systolic volume, of NT-proBNP levels, furosemide dosage and NYHA functional class, together with an increase in EF. These changes were more evident in patients with non-ischemic dilated cardiomyopathy, who showed a significant improvement in ventricular volumes, ejection fraction, TAPSE and blood levels of NT-proBNP. Kaplan–Meier curves confirmed a greater benefit in terms of ejection-fraction improvement in non-ischemic patients compared to the ischemic group. The results of the present study confirm the positive effect of SV on NYHA functional class, NT- proBNP, left ventricular volumes and EF in HFrEF patients, showing evidence of association of SV with ventricular remodeling in patients with dilated cardiomyopathy of non-ischemic etiology compared to the ischemic group. |
| first_indexed | 2024-03-09T12:11:15Z |
| format | Article |
| id | doaj.art-ed55d3fa42ee438094ebab6ad332d14c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T12:11:15Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ed55d3fa42ee438094ebab6ad332d14c2023-11-30T22:52:30ZengMDPI AGJournal of Clinical Medicine2077-03832023-01-0112262110.3390/jcm12020621Reverse Remodeling and Functional Improvement of Left Ventricle in Patients with Chronic Heart Failure Treated with Sacubitril/Valsartan: Comparison between Non-Ischemic and Ischemic EtiologyRoberto Cemin0Simona Casablanca1Luisa Foco2Elisabeth Schoepf3Andrea Erlicher4Renato Di Gaetano5Davide Ermacora6Division of Cardiology, San Maurizio Regional Hospital, 39100 Bolzano, ItalyDivision of Cardiology, San Maurizio Regional Hospital, 39100 Bolzano, ItalyEurac Research, Institute for Biomedicine, University of Lübeck, 39100 Bolzano, ItalyDivision of Cardiology, San Maurizio Regional Hospital, 39100 Bolzano, ItalyDivision of Cardiology, San Maurizio Regional Hospital, 39100 Bolzano, ItalyDivision of Cardiology, San Maurizio Regional Hospital, 39100 Bolzano, ItalyDivision of Cardiology, San Maurizio Regional Hospital, 39100 Bolzano, ItalySacubitril/valsartan (SV) has been demonstrated to reduce cardiovascular mortality, hospitalization for heart failure and to induce reverse ventricular remodeling. The present study was designed to confirm the effects of SV in a selected population of patients with HFrEF and to evaluate the different responses between patients with an ischemic or a non-ischemic etiology. A total of 79 patients with indication of SV were recruited prospectively during a timelapse of 4 years. SV was overall associated to a reduction of end-diastolic and end-systolic volume, of NT-proBNP levels, furosemide dosage and NYHA functional class, together with an increase in EF. These changes were more evident in patients with non-ischemic dilated cardiomyopathy, who showed a significant improvement in ventricular volumes, ejection fraction, TAPSE and blood levels of NT-proBNP. Kaplan–Meier curves confirmed a greater benefit in terms of ejection-fraction improvement in non-ischemic patients compared to the ischemic group. The results of the present study confirm the positive effect of SV on NYHA functional class, NT- proBNP, left ventricular volumes and EF in HFrEF patients, showing evidence of association of SV with ventricular remodeling in patients with dilated cardiomyopathy of non-ischemic etiology compared to the ischemic group.https://www.mdpi.com/2077-0383/12/2/621chronic heart failureventricular functionsacubitril/valsartan |
| spellingShingle | Roberto Cemin Simona Casablanca Luisa Foco Elisabeth Schoepf Andrea Erlicher Renato Di Gaetano Davide Ermacora Reverse Remodeling and Functional Improvement of Left Ventricle in Patients with Chronic Heart Failure Treated with Sacubitril/Valsartan: Comparison between Non-Ischemic and Ischemic Etiology Journal of Clinical Medicine chronic heart failure ventricular function sacubitril/valsartan |
| title | Reverse Remodeling and Functional Improvement of Left Ventricle in Patients with Chronic Heart Failure Treated with Sacubitril/Valsartan: Comparison between Non-Ischemic and Ischemic Etiology |
| title_full | Reverse Remodeling and Functional Improvement of Left Ventricle in Patients with Chronic Heart Failure Treated with Sacubitril/Valsartan: Comparison between Non-Ischemic and Ischemic Etiology |
| title_fullStr | Reverse Remodeling and Functional Improvement of Left Ventricle in Patients with Chronic Heart Failure Treated with Sacubitril/Valsartan: Comparison between Non-Ischemic and Ischemic Etiology |
| title_full_unstemmed | Reverse Remodeling and Functional Improvement of Left Ventricle in Patients with Chronic Heart Failure Treated with Sacubitril/Valsartan: Comparison between Non-Ischemic and Ischemic Etiology |
| title_short | Reverse Remodeling and Functional Improvement of Left Ventricle in Patients with Chronic Heart Failure Treated with Sacubitril/Valsartan: Comparison between Non-Ischemic and Ischemic Etiology |
| title_sort | reverse remodeling and functional improvement of left ventricle in patients with chronic heart failure treated with sacubitril valsartan comparison between non ischemic and ischemic etiology |
| topic | chronic heart failure ventricular function sacubitril/valsartan |
| url | https://www.mdpi.com/2077-0383/12/2/621 |
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