PPARγ ligand ciglitazone inhibits TNFα-induced ICAM-1 in human airway smooth muscle cells

PPARγ ligand ciglitazone inhibits TNFα-induced ICAM-1 in human airway smooth muscle cells

Background: Modification of human airway smooth muscle (ASM) function by proinflammatory cytokines has been regarded as a potential mechanism underlying bronchial hyperresponsiveness in asthma. Human ASM cells express intercellular adhesion molecule (ICAM)-1 in response to cytokines. Synthetic ligan...

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Bibliographic Details
Main Authors: Chien-Da Huang, Te-Chih Hsiung, Shu-Chuan Ho, Kang-Yun Lee, Yao-Fei Chan, Li-Wei Kuo, Shu-Min Lin, Chun-Hua Wang, Horng-Chyuan Lin, Han-Pin Kuo
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Biomedical Journal
Subjects:
airway inflammation
airway smooth muscle
ICAM-1
NF-κB
PPARγ
Online Access:http://www.biomedj.org/article.asp?issn=2319-4170;year=2014;volume=37;issue=4;spage=191;epage=198;aulast=Huang

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