Sense and Immunity: Context-Dependent Neuro-Immune Interplay
The sensory nervous and immune systems, historically considered autonomous, actually work in concert to promote host defense and tissue homeostasis. These systems interact with each other through a common language of cell surface G protein-coupled receptors and receptor tyrosine kinases as well as c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01463/full |
| _version_ | 1828387539001540608 |
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| author | Simmie L. Foster Simmie L. Foster Simmie L. Foster Simmie L. Foster Corey R. Seehus Corey R. Seehus Clifford J. Woolf Clifford J. Woolf Sébastien Talbot |
| author_facet | Simmie L. Foster Simmie L. Foster Simmie L. Foster Simmie L. Foster Corey R. Seehus Corey R. Seehus Clifford J. Woolf Clifford J. Woolf Sébastien Talbot |
| author_sort | Simmie L. Foster |
| collection | DOAJ |
| description | The sensory nervous and immune systems, historically considered autonomous, actually work in concert to promote host defense and tissue homeostasis. These systems interact with each other through a common language of cell surface G protein-coupled receptors and receptor tyrosine kinases as well as cytokines, growth factors, and neuropeptides. While this bidirectional communication is adaptive in many settings, helping protect from danger, it can also become maladaptive and contribute to disease pathophysiology. The fundamental logic of how, where, and when sensory neurons and immune cells contribute to either health or disease remains, however, unclear. Our lab and others’ have begun to explore how this neuro-immune reciprocal dialog contributes to physiological and pathological immune responses and sensory disorders. The cumulative results collected so far indicate that there is an important role for nociceptors (noxious stimulus detecting sensory neurons) in driving immune responses, but that this is highly context dependent. To illustrate this concept, we present our findings in a model of airway inflammation, in which nociceptors seem to have major involvement in type 2 but not type 1 adaptive immunity. |
| first_indexed | 2024-12-10T05:56:07Z |
| format | Article |
| id | doaj.art-ed57602fd5bd470c8b4be6dfcb6e4651 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T05:56:07Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ed57602fd5bd470c8b4be6dfcb6e46512022-12-22T01:59:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-11-01810.3389/fimmu.2017.01463300437Sense and Immunity: Context-Dependent Neuro-Immune InterplaySimmie L. Foster0Simmie L. Foster1Simmie L. Foster2Simmie L. Foster3Corey R. Seehus4Corey R. Seehus5Clifford J. Woolf6Clifford J. Woolf7Sébastien Talbot8F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Boston, MA, United StatesDepartment of Neurobiology, Harvard Medical School, Boston, MA, United StatesDepartment of Psychiatry, Harvard Medical School, Boston, MA, United StatesDepression Clinical Research Program, Massachusetts General Hospital, Boston, MA, United StatesF.M. Kirby Neurobiology Center, Boston Children’s Hospital, Boston, MA, United StatesDepartment of Neurobiology, Harvard Medical School, Boston, MA, United StatesF.M. Kirby Neurobiology Center, Boston Children’s Hospital, Boston, MA, United StatesDepartment of Neurobiology, Harvard Medical School, Boston, MA, United StatesDépartement de Pharmacologie et Physiologie, Université de Montréal, Montréal, QC, CanadaThe sensory nervous and immune systems, historically considered autonomous, actually work in concert to promote host defense and tissue homeostasis. These systems interact with each other through a common language of cell surface G protein-coupled receptors and receptor tyrosine kinases as well as cytokines, growth factors, and neuropeptides. While this bidirectional communication is adaptive in many settings, helping protect from danger, it can also become maladaptive and contribute to disease pathophysiology. The fundamental logic of how, where, and when sensory neurons and immune cells contribute to either health or disease remains, however, unclear. Our lab and others’ have begun to explore how this neuro-immune reciprocal dialog contributes to physiological and pathological immune responses and sensory disorders. The cumulative results collected so far indicate that there is an important role for nociceptors (noxious stimulus detecting sensory neurons) in driving immune responses, but that this is highly context dependent. To illustrate this concept, we present our findings in a model of airway inflammation, in which nociceptors seem to have major involvement in type 2 but not type 1 adaptive immunity.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01463/fullallergy and immunologysensory neuronsasthmainflammationneuro-immunological signaling |
| spellingShingle | Simmie L. Foster Simmie L. Foster Simmie L. Foster Simmie L. Foster Corey R. Seehus Corey R. Seehus Clifford J. Woolf Clifford J. Woolf Sébastien Talbot Sense and Immunity: Context-Dependent Neuro-Immune Interplay Frontiers in Immunology allergy and immunology sensory neurons asthma inflammation neuro-immunological signaling |
| title | Sense and Immunity: Context-Dependent Neuro-Immune Interplay |
| title_full | Sense and Immunity: Context-Dependent Neuro-Immune Interplay |
| title_fullStr | Sense and Immunity: Context-Dependent Neuro-Immune Interplay |
| title_full_unstemmed | Sense and Immunity: Context-Dependent Neuro-Immune Interplay |
| title_short | Sense and Immunity: Context-Dependent Neuro-Immune Interplay |
| title_sort | sense and immunity context dependent neuro immune interplay |
| topic | allergy and immunology sensory neurons asthma inflammation neuro-immunological signaling |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01463/full |
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