N-Acetylcysteine for COVID-19: A Potential Adjuvant Therapy
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) infection or known as coronavirus disease 2019 (COVID-19) is a highly infectious disease that has been declared as a world pandemic by WHO. Although the majority of patients only experience mild symptoms, older patients and those with comor...
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| Format: | Article |
| Language: | English |
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University of Sarajevo
2021-01-01
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| Series: | Journal of Health Sciences |
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| Online Access: | https://www.jhsci.ba/ojs/index.php/jhsci/article/view/1156 |
| _version_ | 1818984334223212544 |
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| author | Mia Elhidsi Fanny Fachrucha Rizky Yudha Irawan |
| author_facet | Mia Elhidsi Fanny Fachrucha Rizky Yudha Irawan |
| author_sort | Mia Elhidsi |
| collection | DOAJ |
| description | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) infection or known as coronavirus disease 2019 (COVID-19) is a highly infectious disease that has been declared as a world pandemic by WHO. Although the majority of patients only experience mild symptoms, older patients and those with comorbidities are in the risk of falling into critically ill and even death. This is thought to correlate with systemic inflammatory response and oxidative stress imbalance. N-acetylcysteine (NAC) is recognized as a potent mucolytic, yet its lesser-known function as an antioxidant is a precursor of glutathione. Basic aspects and either in vivo or in vitro studies showed various mechanisms of NAC acting as a counterbalance in viral infections and its role in decreasing inflammation and oxidative stress. High-dose NAC is reported to be effective as an antioxidant in pneumonia, influenza, sepsis, and acute respiratory distress syndrome. Early evidence in COVID-19 patients showed that NAC could be beneficial. This review gives the scientific background in considering NAC as an adjuvant treatment for COVID-19. |
| first_indexed | 2024-12-20T18:17:21Z |
| format | Article |
| id | doaj.art-ed57891d5e65477984fbfb396b88f8a6 |
| institution | Directory Open Access Journal |
| issn | 2232-7576 1986-8049 |
| language | English |
| last_indexed | 2024-12-20T18:17:21Z |
| publishDate | 2021-01-01 |
| publisher | University of Sarajevo |
| record_format | Article |
| series | Journal of Health Sciences |
| spelling | doaj.art-ed57891d5e65477984fbfb396b88f8a62022-12-21T19:30:21ZengUniversity of SarajevoJournal of Health Sciences2232-75761986-80492021-01-0110.17532/jhsci.2020.1156N-Acetylcysteine for COVID-19: A Potential Adjuvant TherapyMia Elhidsi0Fanny Fachrucha1Rizky Yudha Irawan 2Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, IndonesiaDepartment of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, IndonesiaFaculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, IndonesiaSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) infection or known as coronavirus disease 2019 (COVID-19) is a highly infectious disease that has been declared as a world pandemic by WHO. Although the majority of patients only experience mild symptoms, older patients and those with comorbidities are in the risk of falling into critically ill and even death. This is thought to correlate with systemic inflammatory response and oxidative stress imbalance. N-acetylcysteine (NAC) is recognized as a potent mucolytic, yet its lesser-known function as an antioxidant is a precursor of glutathione. Basic aspects and either in vivo or in vitro studies showed various mechanisms of NAC acting as a counterbalance in viral infections and its role in decreasing inflammation and oxidative stress. High-dose NAC is reported to be effective as an antioxidant in pneumonia, influenza, sepsis, and acute respiratory distress syndrome. Early evidence in COVID-19 patients showed that NAC could be beneficial. This review gives the scientific background in considering NAC as an adjuvant treatment for COVID-19.https://www.jhsci.ba/ojs/index.php/jhsci/article/view/1156antioxidantCOVID-19glutathioneN-acetylcysteineoxidative stress |
| spellingShingle | Mia Elhidsi Fanny Fachrucha Rizky Yudha Irawan N-Acetylcysteine for COVID-19: A Potential Adjuvant Therapy Journal of Health Sciences antioxidant COVID-19 glutathione N-acetylcysteine oxidative stress |
| title | N-Acetylcysteine for COVID-19: A Potential Adjuvant Therapy |
| title_full | N-Acetylcysteine for COVID-19: A Potential Adjuvant Therapy |
| title_fullStr | N-Acetylcysteine for COVID-19: A Potential Adjuvant Therapy |
| title_full_unstemmed | N-Acetylcysteine for COVID-19: A Potential Adjuvant Therapy |
| title_short | N-Acetylcysteine for COVID-19: A Potential Adjuvant Therapy |
| title_sort | n acetylcysteine for covid 19 a potential adjuvant therapy |
| topic | antioxidant COVID-19 glutathione N-acetylcysteine oxidative stress |
| url | https://www.jhsci.ba/ojs/index.php/jhsci/article/view/1156 |
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