The Impact of a Natural Olive-Derived Phytocomplex (OliPhenolia<sup>®</sup>) on Exercise-Induced Oxidative Stress in Healthy Adults
The role of natural polyphenols in reducing oxidative stress and/or supporting antioxidant mechanisms, particularly relating to exercise, is of high interest. The aim of this study was to investigate OliPhenolia<sup>®</sup> (OliP), a biodynamic and organic olive fruit water phytocomplex,...
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MDPI AG
2022-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/23/5156 |
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| author | Justin D. Roberts Joseph Lillis Jorge Marques Pinto Ashley G. B. Willmott Lata Gautam Christopher Davies Álvaro López-Samanes Juan Del Coso Havovi Chichger |
| author_facet | Justin D. Roberts Joseph Lillis Jorge Marques Pinto Ashley G. B. Willmott Lata Gautam Christopher Davies Álvaro López-Samanes Juan Del Coso Havovi Chichger |
| author_sort | Justin D. Roberts |
| collection | DOAJ |
| description | The role of natural polyphenols in reducing oxidative stress and/or supporting antioxidant mechanisms, particularly relating to exercise, is of high interest. The aim of this study was to investigate OliPhenolia<sup>®</sup> (OliP), a biodynamic and organic olive fruit water phytocomplex, rich in hydroxytyrosol (HT), for the first time within an exercise domain. HT bioavailability from OliP was assessed in fifteen healthy volunteers in a randomized, double-blind, placebo controlled cross-over design (age: 30 ± 2 yrs; body mass: 76.7 ± 3.9 kg; height: 1.77 ± 0.02 m), followed by a separate randomized, double-blinded, cohort trial investigating the short-term impact of OliP consumption (2 × 28 mL∙d<sup>−1</sup> of OliP or placebo (PL) for 16-days) on markers of oxidative stress in twenty-nine recreationally active participants (42 ± 2 yrs; 71.1 ± 2.1 kg; 1.76 ± 0.02 m). In response to a single 28 mL OliP bolus, plasma HT peaked at 1 h (38.31 ± 4.76 ng∙mL<sup>−1</sup>), remaining significantly elevated (<i>p</i> < 0.001) until 4 h. Plasma malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and HT were assessed at rest and immediately following exercise (50 min at ~75% <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mover accent="true"><mi mathvariant="normal">V</mi><mo>˙</mo></mover></mrow></semantics></math></inline-formula>O<sub>2</sub>max then 10 min intermittent efforts) and at 1 and 24 h post-exercise, before and after the 16-day supplementation protocol. Plasma HT under resting conditions was not detected pre-intervention, but increased to 6.3 ± 1.6 ng·mL<sup>−1</sup> following OliP only (<i>p</i> < 0.001). OliP demonstrated modest antioxidant effects based on reduced SOD activity post-exercise (<i>p</i> = 0.016) and at 24 h (<i>p</i> ≤ 0.046), and increased GSH immediately post-exercise (<i>p</i> = 0.009) compared with PL. No differences were reported for MDA and CAT activity in response to the exercise protocol between conditions. The phenolic compounds within OliP, including HT, may have specific antioxidant benefits supporting acute exercise recovery. Further research is warranted to explore the impact of OliP following longer-term exercise training, and clinical domains pertinent to reduced oxidative stress. |
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| spelling | doaj.art-ed5c072ea9da4862b708e5a90c724c042023-11-24T11:53:05ZengMDPI AGNutrients2072-66432022-12-011423515610.3390/nu14235156The Impact of a Natural Olive-Derived Phytocomplex (OliPhenolia<sup>®</sup>) on Exercise-Induced Oxidative Stress in Healthy AdultsJustin D. Roberts0Joseph Lillis1Jorge Marques Pinto2Ashley G. B. Willmott3Lata Gautam4Christopher Davies5Álvaro López-Samanes6Juan Del Coso7Havovi Chichger8Cambridge Centre for Sport and Exercise Sciences, School of Psychology and Sport Science, Anglia Ruskin University, Cambridge CB1 1PT, UKCambridge Centre for Sport and Exercise Sciences, School of Psychology and Sport Science, Anglia Ruskin University, Cambridge CB1 1PT, UKCambridge Centre for Sport and Exercise Sciences, School of Psychology and Sport Science, Anglia Ruskin University, Cambridge CB1 1PT, UKCambridge Centre for Sport and Exercise Sciences, School of Psychology and Sport Science, Anglia Ruskin University, Cambridge CB1 1PT, UKSchool of Life Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UKSchool of Life Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UKExercise Physiology Group, Faculty of Health Sciences, Universidad Francisco de Vitoria, 28223 Madrid, SpainCentre for Sport Studies, Rey Juan Carlos University, 28943 Fuenlabrada, SpainSchool of Life Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UKThe role of natural polyphenols in reducing oxidative stress and/or supporting antioxidant mechanisms, particularly relating to exercise, is of high interest. The aim of this study was to investigate OliPhenolia<sup>®</sup> (OliP), a biodynamic and organic olive fruit water phytocomplex, rich in hydroxytyrosol (HT), for the first time within an exercise domain. HT bioavailability from OliP was assessed in fifteen healthy volunteers in a randomized, double-blind, placebo controlled cross-over design (age: 30 ± 2 yrs; body mass: 76.7 ± 3.9 kg; height: 1.77 ± 0.02 m), followed by a separate randomized, double-blinded, cohort trial investigating the short-term impact of OliP consumption (2 × 28 mL∙d<sup>−1</sup> of OliP or placebo (PL) for 16-days) on markers of oxidative stress in twenty-nine recreationally active participants (42 ± 2 yrs; 71.1 ± 2.1 kg; 1.76 ± 0.02 m). In response to a single 28 mL OliP bolus, plasma HT peaked at 1 h (38.31 ± 4.76 ng∙mL<sup>−1</sup>), remaining significantly elevated (<i>p</i> < 0.001) until 4 h. Plasma malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and HT were assessed at rest and immediately following exercise (50 min at ~75% <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mover accent="true"><mi mathvariant="normal">V</mi><mo>˙</mo></mover></mrow></semantics></math></inline-formula>O<sub>2</sub>max then 10 min intermittent efforts) and at 1 and 24 h post-exercise, before and after the 16-day supplementation protocol. Plasma HT under resting conditions was not detected pre-intervention, but increased to 6.3 ± 1.6 ng·mL<sup>−1</sup> following OliP only (<i>p</i> < 0.001). OliP demonstrated modest antioxidant effects based on reduced SOD activity post-exercise (<i>p</i> = 0.016) and at 24 h (<i>p</i> ≤ 0.046), and increased GSH immediately post-exercise (<i>p</i> = 0.009) compared with PL. No differences were reported for MDA and CAT activity in response to the exercise protocol between conditions. The phenolic compounds within OliP, including HT, may have specific antioxidant benefits supporting acute exercise recovery. Further research is warranted to explore the impact of OliP following longer-term exercise training, and clinical domains pertinent to reduced oxidative stress.https://www.mdpi.com/2072-6643/14/23/5156polyphenolsOliPhenolia<sup>®</sup>oxidative stressexercisenutritionantioxidants |
| spellingShingle | Justin D. Roberts Joseph Lillis Jorge Marques Pinto Ashley G. B. Willmott Lata Gautam Christopher Davies Álvaro López-Samanes Juan Del Coso Havovi Chichger The Impact of a Natural Olive-Derived Phytocomplex (OliPhenolia<sup>®</sup>) on Exercise-Induced Oxidative Stress in Healthy Adults Nutrients polyphenols OliPhenolia<sup>®</sup> oxidative stress exercise nutrition antioxidants |
| title | The Impact of a Natural Olive-Derived Phytocomplex (OliPhenolia<sup>®</sup>) on Exercise-Induced Oxidative Stress in Healthy Adults |
| title_full | The Impact of a Natural Olive-Derived Phytocomplex (OliPhenolia<sup>®</sup>) on Exercise-Induced Oxidative Stress in Healthy Adults |
| title_fullStr | The Impact of a Natural Olive-Derived Phytocomplex (OliPhenolia<sup>®</sup>) on Exercise-Induced Oxidative Stress in Healthy Adults |
| title_full_unstemmed | The Impact of a Natural Olive-Derived Phytocomplex (OliPhenolia<sup>®</sup>) on Exercise-Induced Oxidative Stress in Healthy Adults |
| title_short | The Impact of a Natural Olive-Derived Phytocomplex (OliPhenolia<sup>®</sup>) on Exercise-Induced Oxidative Stress in Healthy Adults |
| title_sort | impact of a natural olive derived phytocomplex oliphenolia sup r sup on exercise induced oxidative stress in healthy adults |
| topic | polyphenols OliPhenolia<sup>®</sup> oxidative stress exercise nutrition antioxidants |
| url | https://www.mdpi.com/2072-6643/14/23/5156 |
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