Nanoparticles and Their Antibacterial Application in Endodontics
Root canal treatment represents a significant challenge as current cleaning and disinfection methodologies fail to remove persistent bacterial biofilms within the intricate anatomical structures. Recently, the field of nanotechnology has emerged as a promising frontier with numerous biomedical appli...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/12/12/1690 |
| _version_ | 1797382274649423872 |
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| author | Nicoletta Capuano Alessandra Amato Federica Dell’Annunziata Francesco Giordano Veronica Folliero Federica Di Spirito Pragati Rajendra More Anna De Filippis Stefano Martina Massimo Amato Massimiliano Galdiero Alfredo Iandolo Gianluigi Franci |
| author_facet | Nicoletta Capuano Alessandra Amato Federica Dell’Annunziata Francesco Giordano Veronica Folliero Federica Di Spirito Pragati Rajendra More Anna De Filippis Stefano Martina Massimo Amato Massimiliano Galdiero Alfredo Iandolo Gianluigi Franci |
| author_sort | Nicoletta Capuano |
| collection | DOAJ |
| description | Root canal treatment represents a significant challenge as current cleaning and disinfection methodologies fail to remove persistent bacterial biofilms within the intricate anatomical structures. Recently, the field of nanotechnology has emerged as a promising frontier with numerous biomedical applications. Among the most notable contributions of nanotechnology are nanoparticles, which possess antimicrobial, antifungal, and antiviral properties. Nanoparticles cause the destructuring of bacterial walls, increasing the permeability of the cell membrane, stimulating the generation of reactive oxygen species, and interrupting the replication of deoxyribonucleic acid through the controlled release of ions. Thus, they could revolutionize endodontics, obtaining superior results and guaranteeing a promising short- and long-term prognosis. Therefore, chitosan, silver, graphene, poly(lactic) co-glycolic acid, bioactive glass, mesoporous calcium silicate, hydroxyapatite, zirconia, glucose oxidase magnetic, copper, and zinc oxide nanoparticles in endodontic therapy have been investigated in the present review. The diversified antimicrobial mechanisms of action, the numerous applications, and the high degree of clinical safety could encourage the scientific community to adopt nanoparticles as potential drugs for the treatment of endodontic diseases, overcoming the limitations related to antibiotic resistance and eradication of the biofilm. |
| first_indexed | 2024-03-08T21:04:05Z |
| format | Article |
| id | doaj.art-ed5e2370232041f08af38fb26ce70f9f |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-08T21:04:05Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-ed5e2370232041f08af38fb26ce70f9f2023-12-22T13:47:54ZengMDPI AGAntibiotics2079-63822023-12-011212169010.3390/antibiotics12121690Nanoparticles and Their Antibacterial Application in EndodonticsNicoletta Capuano0Alessandra Amato1Federica Dell’Annunziata2Francesco Giordano3Veronica Folliero4Federica Di Spirito5Pragati Rajendra More6Anna De Filippis7Stefano Martina8Massimo Amato9Massimiliano Galdiero10Alfredo Iandolo11Gianluigi Franci12Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Neuroscience, Reproductive Science and Dentistry, University of Naples Federico II, 80138 Naples, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyRoot canal treatment represents a significant challenge as current cleaning and disinfection methodologies fail to remove persistent bacterial biofilms within the intricate anatomical structures. Recently, the field of nanotechnology has emerged as a promising frontier with numerous biomedical applications. Among the most notable contributions of nanotechnology are nanoparticles, which possess antimicrobial, antifungal, and antiviral properties. Nanoparticles cause the destructuring of bacterial walls, increasing the permeability of the cell membrane, stimulating the generation of reactive oxygen species, and interrupting the replication of deoxyribonucleic acid through the controlled release of ions. Thus, they could revolutionize endodontics, obtaining superior results and guaranteeing a promising short- and long-term prognosis. Therefore, chitosan, silver, graphene, poly(lactic) co-glycolic acid, bioactive glass, mesoporous calcium silicate, hydroxyapatite, zirconia, glucose oxidase magnetic, copper, and zinc oxide nanoparticles in endodontic therapy have been investigated in the present review. The diversified antimicrobial mechanisms of action, the numerous applications, and the high degree of clinical safety could encourage the scientific community to adopt nanoparticles as potential drugs for the treatment of endodontic diseases, overcoming the limitations related to antibiotic resistance and eradication of the biofilm.https://www.mdpi.com/2079-6382/12/12/1690nanotechnologyinfectiondentistrycleaningroot canalbiofilm matrix |
| spellingShingle | Nicoletta Capuano Alessandra Amato Federica Dell’Annunziata Francesco Giordano Veronica Folliero Federica Di Spirito Pragati Rajendra More Anna De Filippis Stefano Martina Massimo Amato Massimiliano Galdiero Alfredo Iandolo Gianluigi Franci Nanoparticles and Their Antibacterial Application in Endodontics Antibiotics nanotechnology infection dentistry cleaning root canal biofilm matrix |
| title | Nanoparticles and Their Antibacterial Application in Endodontics |
| title_full | Nanoparticles and Their Antibacterial Application in Endodontics |
| title_fullStr | Nanoparticles and Their Antibacterial Application in Endodontics |
| title_full_unstemmed | Nanoparticles and Their Antibacterial Application in Endodontics |
| title_short | Nanoparticles and Their Antibacterial Application in Endodontics |
| title_sort | nanoparticles and their antibacterial application in endodontics |
| topic | nanotechnology infection dentistry cleaning root canal biofilm matrix |
| url | https://www.mdpi.com/2079-6382/12/12/1690 |
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