Direct Thrombin Inhibitor Dabigatran Compromises Pulmonary Endothelial Integrity in a Murine Model of Breast Cancer Metastasis to the Lungs; the Role of Platelets and Inflammation-Associated Haemostasis

Direct Thrombin Inhibitor Dabigatran Compromises Pulmonary Endothelial Integrity in a Murine Model of Breast Cancer Metastasis to the Lungs; the Role of Platelets and Inflammation-Associated Haemostasis

Activation of the coagulation cascade favours metastatic spread, but antithrombotic therapy might also have detrimental effects on cancer progression. In this study, we characterized the effects of dabigatran, a direct reversible thrombin inhibitor, on the pulmonary endothelial barrier and metastati...

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Bibliographic Details
Main Authors: Marta Smeda, Marta Stojak, Kamil Przyborowski, Magdalena Sternak, Joanna Suraj-Prazmowska, Kamil Kus, Katarzyna Derszniak, Agnieszka Jasztal, Agnieszka Kij, Anna Kurpinska, Anna Kieronska-Rudek, Kamila Wojnar-Lason, Elzbieta Buczek, Tasnim Mohaissen, Stefan Chlopicki
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
breast cancer
pulmonary metastasis
dabigatran
thrombin
platelets
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.834472/full

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