Background and roles: myosin in autoimmune diseases
The myosin superfamily is a group of molecular motors. Autoimmune diseases are characterized by dysregulation or deficiency of the immune tolerance mechanism, resulting in an immune response to the human body itself. The link between myosin and autoimmune diseases is much more complex than scientist...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1220672/full |
| _version_ | 1797738358204530688 |
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| author | Longsheng Fu Yonghui Zou Boyang Yu Daojun Hong Teng Guan Jinfang Hu Yi Xu Yaoqi Wu Junping Kou Yanni Lv |
| author_facet | Longsheng Fu Yonghui Zou Boyang Yu Daojun Hong Teng Guan Jinfang Hu Yi Xu Yaoqi Wu Junping Kou Yanni Lv |
| author_sort | Longsheng Fu |
| collection | DOAJ |
| description | The myosin superfamily is a group of molecular motors. Autoimmune diseases are characterized by dysregulation or deficiency of the immune tolerance mechanism, resulting in an immune response to the human body itself. The link between myosin and autoimmune diseases is much more complex than scientists had hoped. Myosin itself immunization can induce experimental autoimmune diseases of animals, and myosins were abnormally expressed in a number of autoimmune diseases. Additionally, myosin takes part in the pathological process of multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, autoimmune myocarditis, myositis, hemopathy, inclusion body diseases, etc. However, research on myosin and its involvement in the occurrence and development of diseases is still in its infancy, and the underlying pathological mechanisms are not well understood. We can reasonably predict that myosin might play a role in new treatments of autoimmune diseases. |
| first_indexed | 2024-03-12T13:41:42Z |
| format | Article |
| id | doaj.art-ed60f21071104fd1b79392f01aa2125b |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-12T13:41:42Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-ed60f21071104fd1b79392f01aa2125b2023-08-23T15:05:31ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-08-011110.3389/fcell.2023.12206721220672Background and roles: myosin in autoimmune diseasesLongsheng Fu0Yonghui Zou1Boyang Yu2Daojun Hong3Teng Guan4Jinfang Hu5Yi Xu6Yaoqi Wu7Junping Kou8Yanni Lv9Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaJiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangxi, ChinaDepartment of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, CanadaDepartment of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaJiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangxi, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaThe myosin superfamily is a group of molecular motors. Autoimmune diseases are characterized by dysregulation or deficiency of the immune tolerance mechanism, resulting in an immune response to the human body itself. The link between myosin and autoimmune diseases is much more complex than scientists had hoped. Myosin itself immunization can induce experimental autoimmune diseases of animals, and myosins were abnormally expressed in a number of autoimmune diseases. Additionally, myosin takes part in the pathological process of multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, autoimmune myocarditis, myositis, hemopathy, inclusion body diseases, etc. However, research on myosin and its involvement in the occurrence and development of diseases is still in its infancy, and the underlying pathological mechanisms are not well understood. We can reasonably predict that myosin might play a role in new treatments of autoimmune diseases.https://www.frontiersin.org/articles/10.3389/fcell.2023.1220672/fullmyosinautoimmuneautoimmune myocardioptisNMMHC IIAmultiple sclerosisAlzheimer |
| spellingShingle | Longsheng Fu Yonghui Zou Boyang Yu Daojun Hong Teng Guan Jinfang Hu Yi Xu Yaoqi Wu Junping Kou Yanni Lv Background and roles: myosin in autoimmune diseases Frontiers in Cell and Developmental Biology myosin autoimmune autoimmune myocardioptis NMMHC IIA multiple sclerosis Alzheimer |
| title | Background and roles: myosin in autoimmune diseases |
| title_full | Background and roles: myosin in autoimmune diseases |
| title_fullStr | Background and roles: myosin in autoimmune diseases |
| title_full_unstemmed | Background and roles: myosin in autoimmune diseases |
| title_short | Background and roles: myosin in autoimmune diseases |
| title_sort | background and roles myosin in autoimmune diseases |
| topic | myosin autoimmune autoimmune myocardioptis NMMHC IIA multiple sclerosis Alzheimer |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1220672/full |
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