Hypoxia promotes gastric cancer malignancy partly through the HIF-1α dependent transcriptional activation of the long non-coding RNA GAPLINC

Hypoxia promotes gastric cancer malignancy partly through the HIF-1α dependent transcriptional activation of the long non-coding RNA GAPLINC

Hypoxia-inducible factor (HIF) activates the transcription of genes involved in cancer progression. Recently, HIF was reported to regulate the transcription of non-coding RNAs. Here, we show that the transcription of a long non-coding RNA (lncRNA), Gastric Adenocarcinoma Associated, Positive CD44 Re...

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Bibliographic Details
Main Authors: Lei Liu, Xihe Zhao, Huawei Zou, Rubing Bai, Keyu Yang, Zhong Tian
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Physiology
Subjects:
hypoxia
lncRNA
gastric cancer
HIF-1α
GAPLINC
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00420/full

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