315 Non-invasive and quantitative surgical outcome evaluation of patients with sagittal craniosynostosis undergoing sagittal craniectomy
OBJECTIVES/GOALS: Craniosynostosis is the premature fusion of one or more cranial sutures that produces brain growth constraints and typically requires surgical treatment. We present an age- and sex-specific method to evaluate surgical outcomes using non-invasive 3D photogrammetry that brings object...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2023-04-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2059866123003679/type/journal_article |
| _version_ | 1797840445492953088 |
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| author | Connor Elkhill Jiawei Liu Marius George Linguraru Scott LeBeau David Khechoyan Brooke French Antonio R. Porras |
| author_facet | Connor Elkhill Jiawei Liu Marius George Linguraru Scott LeBeau David Khechoyan Brooke French Antonio R. Porras |
| author_sort | Connor Elkhill |
| collection | DOAJ |
| description | OBJECTIVES/GOALS: Craniosynostosis is the premature fusion of one or more cranial sutures that produces brain growth constraints and typically requires surgical treatment. We present an age- and sex-specific method to evaluate surgical outcomes using non-invasive 3D photogrammetry that brings objectivity to the current approach for clinical assessment. METHODS/STUDY POPULATION: First, we created standardized head anatomy representations for 2,020 patients (1,081 males, 939 females, age 3.14 ± 3.05 years) without cranial pathology from their computed tomography (CT) images based on our previous methods. We used principal component regression stratified by sex to establish age-specific normative ranges of anatomical variability and we designed a new metric called cranial shape abnormality (CSA) index that calculates the number of standard deviations from normality of a given patient’s head anatomy. We calculated our CSA index in a group of 56 patients (44 male, 12 female) with sagittal craniosynostosis who underwent sagittal craniectomy from their pre- (22 ± 30 days before surgery) and post-surgical (267 ± 63 days after surgery) 3D photograms to evaluate surgical outcomes. RESULTS/ANTICIPATED RESULTS: We observed a reduction in the CSA index from 1.28 ± 0.26 before surgery to 0.87 ± 0.22 after surgery (p < 0.001 with a paired Wilcoxon test). The CSA index decreased in 53 of 56 patients (94.6%), who consistently showed head shape improvements after corrective surgery during clinical evaluation. Linear temporal regression indicates a CSA index decrease of 0.43 ± 0.05 during the first year after surgery. We found no significant correlation between a patient’s age at surgery and the patient’s CSA index after surgery (Pearson’s correlation coefficient 0.17, p = 0.20) or the patient’s change in CSA index before and after surgery (Pearson’s correlation coefficient 0.22, p = 0.11), suggesting that sagittal craniectomy is equally effective for all patients who are between 85 and 331 days old at the time of surgery. DISCUSSION/SIGNIFICANCE: Our new CSA index is a sex- and age-specific metric of head shape anomalies built upon the observed statistical distributions in the normative pediatric population. Our metric can objectively evaluate pre- and post-surgical head shapes and will allow the investigation of the reported variability in surgical outcomes among patients and procedures. |
| first_indexed | 2024-04-09T16:15:13Z |
| format | Article |
| id | doaj.art-ed635f9da9d843b8a4ec4fca9b3569ec |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-09T16:15:13Z |
| publishDate | 2023-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-ed635f9da9d843b8a4ec4fca9b3569ec2023-04-24T05:55:56ZengCambridge University PressJournal of Clinical and Translational Science2059-86612023-04-017949510.1017/cts.2023.367315 Non-invasive and quantitative surgical outcome evaluation of patients with sagittal craniosynostosis undergoing sagittal craniectomyConnor Elkhill0Jiawei Liu1Marius George Linguraru2Scott LeBeau3David Khechoyan4Brooke French5Antonio R. Porras6Computational Bioscience Program, University of Colorado Anschutz Medical CampusDepartment of Biostatistics and Informatics, Colorado School of Public HealthChildren's National Health System, Washington, DCPlastic & Reconstructive Surgery, Children's Hospital ColoradoPlastic & Reconstructive Surgery Children's Hospital Colorado, University of Colorado School of MedicinePlastic & Reconstructive Surgery Children's Hospital Colorado, University of Colorado School of MedicineDepartment of Biostatistics and Informatics, Colorado School of Public Health, Children's Hospital ColoradoOBJECTIVES/GOALS: Craniosynostosis is the premature fusion of one or more cranial sutures that produces brain growth constraints and typically requires surgical treatment. We present an age- and sex-specific method to evaluate surgical outcomes using non-invasive 3D photogrammetry that brings objectivity to the current approach for clinical assessment. METHODS/STUDY POPULATION: First, we created standardized head anatomy representations for 2,020 patients (1,081 males, 939 females, age 3.14 ± 3.05 years) without cranial pathology from their computed tomography (CT) images based on our previous methods. We used principal component regression stratified by sex to establish age-specific normative ranges of anatomical variability and we designed a new metric called cranial shape abnormality (CSA) index that calculates the number of standard deviations from normality of a given patient’s head anatomy. We calculated our CSA index in a group of 56 patients (44 male, 12 female) with sagittal craniosynostosis who underwent sagittal craniectomy from their pre- (22 ± 30 days before surgery) and post-surgical (267 ± 63 days after surgery) 3D photograms to evaluate surgical outcomes. RESULTS/ANTICIPATED RESULTS: We observed a reduction in the CSA index from 1.28 ± 0.26 before surgery to 0.87 ± 0.22 after surgery (p < 0.001 with a paired Wilcoxon test). The CSA index decreased in 53 of 56 patients (94.6%), who consistently showed head shape improvements after corrective surgery during clinical evaluation. Linear temporal regression indicates a CSA index decrease of 0.43 ± 0.05 during the first year after surgery. We found no significant correlation between a patient’s age at surgery and the patient’s CSA index after surgery (Pearson’s correlation coefficient 0.17, p = 0.20) or the patient’s change in CSA index before and after surgery (Pearson’s correlation coefficient 0.22, p = 0.11), suggesting that sagittal craniectomy is equally effective for all patients who are between 85 and 331 days old at the time of surgery. DISCUSSION/SIGNIFICANCE: Our new CSA index is a sex- and age-specific metric of head shape anomalies built upon the observed statistical distributions in the normative pediatric population. Our metric can objectively evaluate pre- and post-surgical head shapes and will allow the investigation of the reported variability in surgical outcomes among patients and procedures.https://www.cambridge.org/core/product/identifier/S2059866123003679/type/journal_article |
| spellingShingle | Connor Elkhill Jiawei Liu Marius George Linguraru Scott LeBeau David Khechoyan Brooke French Antonio R. Porras 315 Non-invasive and quantitative surgical outcome evaluation of patients with sagittal craniosynostosis undergoing sagittal craniectomy Journal of Clinical and Translational Science |
| title | 315 Non-invasive and quantitative surgical outcome evaluation of patients with sagittal craniosynostosis undergoing sagittal craniectomy |
| title_full | 315 Non-invasive and quantitative surgical outcome evaluation of patients with sagittal craniosynostosis undergoing sagittal craniectomy |
| title_fullStr | 315 Non-invasive and quantitative surgical outcome evaluation of patients with sagittal craniosynostosis undergoing sagittal craniectomy |
| title_full_unstemmed | 315 Non-invasive and quantitative surgical outcome evaluation of patients with sagittal craniosynostosis undergoing sagittal craniectomy |
| title_short | 315 Non-invasive and quantitative surgical outcome evaluation of patients with sagittal craniosynostosis undergoing sagittal craniectomy |
| title_sort | 315 non invasive and quantitative surgical outcome evaluation of patients with sagittal craniosynostosis undergoing sagittal craniectomy |
| url | https://www.cambridge.org/core/product/identifier/S2059866123003679/type/journal_article |
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