Effect of serum cystatin C in early diabetic nephropathy in type 2 Iraqi diabetic patients
Objective This study aimed to find the effect of serum Cystatin C in early diabetic nephropathy. Method This study was conducted in Al Kindy Teaching Hospital during the period from December, 2015 to June, 2016. The study included 90 subjects (30 males and 30 females) with diabetic type 2 and 30 hea...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nab'a Al-Hayat Foundation for Medical Sciences and Health Care - Press
2017-06-01
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| Series: | Journal of Contemporary Medical Sciences |
| Online Access: | http://www.jocms.org/index.php/jcms/article/view/152 |
| _version_ | 1811262997398552576 |
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| author | Ahmed Abed Kadhem Al-Saedy Kismet M. Turki Shaymaa Z. Nadaa |
| author_facet | Ahmed Abed Kadhem Al-Saedy Kismet M. Turki Shaymaa Z. Nadaa |
| author_sort | Ahmed Abed Kadhem Al-Saedy |
| collection | DOAJ |
| description | Objective This study aimed to find the effect of serum Cystatin C in early diabetic nephropathy.
Method This study was conducted in Al Kindy Teaching Hospital during the period from December, 2015 to June, 2016. The study included 90 subjects (30 males and 30 females) with diabetic type 2 and 30 healthy control. Age is between 30 and 70 years. Patients were with no history of liver disease, thyroid or other endocrine diseases through clinical interviewing. They were divided in to three groups. 30 healthy controls, 30 patients with type 2 diabetes mellitus with no albuminuria (albumin excretion in urine <30 μg/ml ) and 30 patients with type 2 diabetes mellitus with micro albuminuria (albumin excretion in urine >30 μg/ml ).
Results There were no significant differences in age, body mass index (BMI) among the studied groups (p > 0.05). Serum Cystatin C levels showed significant difference (p < 0.001) among studied groups, it was significantly higher in micro albuminuria than the other two groups. There was highly significant positive correlation between Cystatin C and serum creatinine (r = 0.697, p < 0.001), and a significant negative correlation between Cystatin C and GFR (r = − 0.455, p = 0.011) and show significant positive correlation between Cystatin C and urine albumin (r = 0.526, p = 0.003 ) in type 2 diabetic patients with micro albuminuria.
Conclusion Cystatin C is negatively correlated with the amount of GFR, so that Cystatin C considered reliable and sensitive marker for identifying
changes in GFR. In type 2 diabetes mellitus with micro albuminuria serum Cystatin C level considered predict marker for renal failure. |
| first_indexed | 2024-04-12T19:37:03Z |
| format | Article |
| id | doaj.art-ed69b12eea65467fb0713e270649a2c5 |
| institution | Directory Open Access Journal |
| issn | 2415-1629 2413-0516 |
| language | English |
| last_indexed | 2024-04-12T19:37:03Z |
| publishDate | 2017-06-01 |
| publisher | Nab'a Al-Hayat Foundation for Medical Sciences and Health Care - Press |
| record_format | Article |
| series | Journal of Contemporary Medical Sciences |
| spelling | doaj.art-ed69b12eea65467fb0713e270649a2c52022-12-22T03:19:11ZengNab'a Al-Hayat Foundation for Medical Sciences and Health Care - PressJournal of Contemporary Medical Sciences2415-16292413-05162017-06-01310152Effect of serum cystatin C in early diabetic nephropathy in type 2 Iraqi diabetic patientsAhmed Abed Kadhem Al-Saedy0Kismet M. Turki1Shaymaa Z. Nadaa2Department of Biochemistry, College of Medicine, University of Karbala, Holy Karbala cityDepartment of Biochemistry, College of Medicine, University of Baghdad, BaghdadDepartment of Biochemistry, College of Medicine, University of KerbalaObjective This study aimed to find the effect of serum Cystatin C in early diabetic nephropathy. Method This study was conducted in Al Kindy Teaching Hospital during the period from December, 2015 to June, 2016. The study included 90 subjects (30 males and 30 females) with diabetic type 2 and 30 healthy control. Age is between 30 and 70 years. Patients were with no history of liver disease, thyroid or other endocrine diseases through clinical interviewing. They were divided in to three groups. 30 healthy controls, 30 patients with type 2 diabetes mellitus with no albuminuria (albumin excretion in urine <30 μg/ml ) and 30 patients with type 2 diabetes mellitus with micro albuminuria (albumin excretion in urine >30 μg/ml ). Results There were no significant differences in age, body mass index (BMI) among the studied groups (p > 0.05). Serum Cystatin C levels showed significant difference (p < 0.001) among studied groups, it was significantly higher in micro albuminuria than the other two groups. There was highly significant positive correlation between Cystatin C and serum creatinine (r = 0.697, p < 0.001), and a significant negative correlation between Cystatin C and GFR (r = − 0.455, p = 0.011) and show significant positive correlation between Cystatin C and urine albumin (r = 0.526, p = 0.003 ) in type 2 diabetic patients with micro albuminuria. Conclusion Cystatin C is negatively correlated with the amount of GFR, so that Cystatin C considered reliable and sensitive marker for identifying changes in GFR. In type 2 diabetes mellitus with micro albuminuria serum Cystatin C level considered predict marker for renal failure.http://www.jocms.org/index.php/jcms/article/view/152 |
| spellingShingle | Ahmed Abed Kadhem Al-Saedy Kismet M. Turki Shaymaa Z. Nadaa Effect of serum cystatin C in early diabetic nephropathy in type 2 Iraqi diabetic patients Journal of Contemporary Medical Sciences |
| title | Effect of serum cystatin C in early diabetic nephropathy in type 2 Iraqi diabetic patients |
| title_full | Effect of serum cystatin C in early diabetic nephropathy in type 2 Iraqi diabetic patients |
| title_fullStr | Effect of serum cystatin C in early diabetic nephropathy in type 2 Iraqi diabetic patients |
| title_full_unstemmed | Effect of serum cystatin C in early diabetic nephropathy in type 2 Iraqi diabetic patients |
| title_short | Effect of serum cystatin C in early diabetic nephropathy in type 2 Iraqi diabetic patients |
| title_sort | effect of serum cystatin c in early diabetic nephropathy in type 2 iraqi diabetic patients |
| url | http://www.jocms.org/index.php/jcms/article/view/152 |
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