USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells
Gain-of-function mutants of p53 are important for cancer development and strategies to target specifically these isoforms are being investigated. Here the authors report that USP15 is a deubiquitinase specifically regulating p53-R175H levels that can be targeted by a small molecule.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03599-w |
| _version_ | 1818341845769388032 |
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| author | Achuth Padmanabhan Nicholes Candelaria Kwong-Kwok Wong Bryan C. Nikolai David M. Lonard Bert W. O’Malley JoAnne S. Richards |
| author_facet | Achuth Padmanabhan Nicholes Candelaria Kwong-Kwok Wong Bryan C. Nikolai David M. Lonard Bert W. O’Malley JoAnne S. Richards |
| author_sort | Achuth Padmanabhan |
| collection | DOAJ |
| description | Gain-of-function mutants of p53 are important for cancer development and strategies to target specifically these isoforms are being investigated. Here the authors report that USP15 is a deubiquitinase specifically regulating p53-R175H levels that can be targeted by a small molecule. |
| first_indexed | 2024-12-13T16:05:16Z |
| format | Article |
| id | doaj.art-ed69d97e703b4b0db8b927bb34b0aba6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:05:16Z |
| publishDate | 2018-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ed69d97e703b4b0db8b927bb34b0aba62022-12-21T23:39:04ZengNature PortfolioNature Communications2041-17232018-03-019111310.1038/s41467-018-03599-wUSP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cellsAchuth Padmanabhan0Nicholes Candelaria1Kwong-Kwok Wong2Bryan C. Nikolai3David M. Lonard4Bert W. O’Malley5JoAnne S. Richards6Department of Molecular and Cellular Biology, Baylor College of MedicineDepartment of Molecular and Cellular Biology, Baylor College of MedicineDepartment of Gynecologic Oncology and Reproductive Medicine - Research, Division of Surgery, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Biology, Baylor College of MedicineDepartment of Molecular and Cellular Biology, Baylor College of MedicineDepartment of Molecular and Cellular Biology, Baylor College of MedicineDepartment of Molecular and Cellular Biology, Baylor College of MedicineGain-of-function mutants of p53 are important for cancer development and strategies to target specifically these isoforms are being investigated. Here the authors report that USP15 is a deubiquitinase specifically regulating p53-R175H levels that can be targeted by a small molecule.https://doi.org/10.1038/s41467-018-03599-w |
| spellingShingle | Achuth Padmanabhan Nicholes Candelaria Kwong-Kwok Wong Bryan C. Nikolai David M. Lonard Bert W. O’Malley JoAnne S. Richards USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells Nature Communications |
| title | USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells |
| title_full | USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells |
| title_fullStr | USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells |
| title_full_unstemmed | USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells |
| title_short | USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells |
| title_sort | usp15 dependent lysosomal pathway controls p53 r175h turnover in ovarian cancer cells |
| url | https://doi.org/10.1038/s41467-018-03599-w |
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