Multiomic Analysis of Cereblon Expression and Its Prognostic Value in Kidney Renal Clear Cell Carcinoma, Lung Adenocarcinoma, and Skin Cutaneous Melanoma
Cereblon (CRBN) is a component of the E3 ubiquitin ligase complex that plays crucial roles in various cellular processes. However, no systematic studies on the expression and functions of <i>CRBN</i> in solid tumors have been conducted to date. Here, we analyzed <i>CRBN</i> e...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/4/263 |
| _version_ | 1797539146737123328 |
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| author | Hyo Jae Shin Kyung Jin Lee Minchan Gil |
| author_facet | Hyo Jae Shin Kyung Jin Lee Minchan Gil |
| author_sort | Hyo Jae Shin |
| collection | DOAJ |
| description | Cereblon (CRBN) is a component of the E3 ubiquitin ligase complex that plays crucial roles in various cellular processes. However, no systematic studies on the expression and functions of <i>CRBN</i> in solid tumors have been conducted to date. Here, we analyzed <i>CRBN</i> expression and its clinical value using several bioinformatic databases. <i>CRBN</i> mRNA expression was downregulated in various cancer types compared to normal cells. Survival analysis demonstrated that overall survival was significantly positively correlated with <i>CRBN</i> expression in some cancer types including lung adenocarcinoma (LUAD), kidney renal clear cell carcinoma (KIRC), and skin cutaneous melanoma (SKCM). <i>CRBN</i> expression was downregulated regardless of clinicopathological characteristics in LUAD and KIRC. Analysis of genes that are commonly correlated with <i>CRBN</i> expression among KIRC, LUAD, and SKCM samples elucidated the potential CRBN-associated mechanisms of cancer progression. Overall, this study revealed the prognostic value of CRBN and its potential associated mechanisms, which may facilitate the development of anti-cancer therapeutic agents. |
| first_indexed | 2024-03-10T12:41:05Z |
| format | Article |
| id | doaj.art-ed6a85efb7c94dab9c06816c42b84e68 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T12:41:05Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-ed6a85efb7c94dab9c06816c42b84e682023-11-21T13:54:45ZengMDPI AGJournal of Personalized Medicine2075-44262021-04-0111426310.3390/jpm11040263Multiomic Analysis of Cereblon Expression and Its Prognostic Value in Kidney Renal Clear Cell Carcinoma, Lung Adenocarcinoma, and Skin Cutaneous MelanomaHyo Jae Shin0Kyung Jin Lee1Minchan Gil2Department of Biological Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, KoreaDepartment of Convergence Medicine, Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, KoreaDepartment of Stem Cell and Regenerative Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, KoreaCereblon (CRBN) is a component of the E3 ubiquitin ligase complex that plays crucial roles in various cellular processes. However, no systematic studies on the expression and functions of <i>CRBN</i> in solid tumors have been conducted to date. Here, we analyzed <i>CRBN</i> expression and its clinical value using several bioinformatic databases. <i>CRBN</i> mRNA expression was downregulated in various cancer types compared to normal cells. Survival analysis demonstrated that overall survival was significantly positively correlated with <i>CRBN</i> expression in some cancer types including lung adenocarcinoma (LUAD), kidney renal clear cell carcinoma (KIRC), and skin cutaneous melanoma (SKCM). <i>CRBN</i> expression was downregulated regardless of clinicopathological characteristics in LUAD and KIRC. Analysis of genes that are commonly correlated with <i>CRBN</i> expression among KIRC, LUAD, and SKCM samples elucidated the potential CRBN-associated mechanisms of cancer progression. Overall, this study revealed the prognostic value of CRBN and its potential associated mechanisms, which may facilitate the development of anti-cancer therapeutic agents.https://www.mdpi.com/2075-4426/11/4/263cereblonmultiomic analysislung adenocarcinomakidney renal clear cell carcinomaskin cutaneous melanomaprognostic value |
| spellingShingle | Hyo Jae Shin Kyung Jin Lee Minchan Gil Multiomic Analysis of Cereblon Expression and Its Prognostic Value in Kidney Renal Clear Cell Carcinoma, Lung Adenocarcinoma, and Skin Cutaneous Melanoma Journal of Personalized Medicine cereblon multiomic analysis lung adenocarcinoma kidney renal clear cell carcinoma skin cutaneous melanoma prognostic value |
| title | Multiomic Analysis of Cereblon Expression and Its Prognostic Value in Kidney Renal Clear Cell Carcinoma, Lung Adenocarcinoma, and Skin Cutaneous Melanoma |
| title_full | Multiomic Analysis of Cereblon Expression and Its Prognostic Value in Kidney Renal Clear Cell Carcinoma, Lung Adenocarcinoma, and Skin Cutaneous Melanoma |
| title_fullStr | Multiomic Analysis of Cereblon Expression and Its Prognostic Value in Kidney Renal Clear Cell Carcinoma, Lung Adenocarcinoma, and Skin Cutaneous Melanoma |
| title_full_unstemmed | Multiomic Analysis of Cereblon Expression and Its Prognostic Value in Kidney Renal Clear Cell Carcinoma, Lung Adenocarcinoma, and Skin Cutaneous Melanoma |
| title_short | Multiomic Analysis of Cereblon Expression and Its Prognostic Value in Kidney Renal Clear Cell Carcinoma, Lung Adenocarcinoma, and Skin Cutaneous Melanoma |
| title_sort | multiomic analysis of cereblon expression and its prognostic value in kidney renal clear cell carcinoma lung adenocarcinoma and skin cutaneous melanoma |
| topic | cereblon multiomic analysis lung adenocarcinoma kidney renal clear cell carcinoma skin cutaneous melanoma prognostic value |
| url | https://www.mdpi.com/2075-4426/11/4/263 |
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