Multiomic Analysis of Cereblon Expression and Its Prognostic Value in Kidney Renal Clear Cell Carcinoma, Lung Adenocarcinoma, and Skin Cutaneous Melanoma

Multiomic Analysis of Cereblon Expression and Its Prognostic Value in Kidney Renal Clear Cell Carcinoma, Lung Adenocarcinoma, and Skin Cutaneous Melanoma

Cereblon (CRBN) is a component of the E3 ubiquitin ligase complex that plays crucial roles in various cellular processes. However, no systematic studies on the expression and functions of <i>CRBN</i> in solid tumors have been conducted to date. Here, we analyzed <i>CRBN</i> e...

Full description

Bibliographic Details
Main Authors:	Hyo Jae Shin, Kyung Jin Lee, Minchan Gil
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Journal of Personalized Medicine
Subjects:	cereblon multiomic analysis lung adenocarcinoma kidney renal clear cell carcinoma skin cutaneous melanoma prognostic value
Online Access:	https://www.mdpi.com/2075-4426/11/4/263

Similar Items

Systematic Multiomic Analysis of <i>PKHD1L1</i> Gene Expression and Its Role as a Predicting Biomarker for Immune Cell Infiltration in Skin Cutaneous Melanoma and Lung Adenocarcinoma
by: Ji Young Kang, et al.
Published: (2023-12-01)

UBE2G1 governs the destruction of cereblon neomorphic substrates
by: Gang Lu, et al.
Published: (2018-09-01)

The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls
by: Carlos Costas-Insua, et al.
Published: (2024-03-01)

Systematic Multiomic Analysis of <i>Ly75</i> Gene Expression and Its Prognostic Value through the Infiltration of Natural Killer (NK) Cells in Skin Cutaneous Melanoma
by: Minchan Gil, et al.
Published: (2020-05-01)

Multiomics characterization of pyroptosis in the tumor microenvironment and therapeutic relevance in metastatic melanoma
by: Wenqiong Chen, et al.
Published: (2024-01-01)

Cutaneous Clear Cell Sarcoma: A Rare Aggressive Tumor with Potential Diagnostic Challenge
by: Akshay Bali, et al.
Published: (2012-01-01)

Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs
by: Megan L. Peach, et al.
Published: (2020-12-01)

Cereblon Deficiency Contributes to the Development of Elastase-Induced Emphysema by Enhancing NF-κB Activation
by: Eun-Young Heo, et al.
Published: (2022-10-01)

Molecular Mechanisms of Cereblon-Interacting Small Molecules in Multiple Myeloma Therapy
by: Matteo Costacurta, et al.
Published: (2021-11-01)

Multiomics characterization and verification of clear cell renal cell carcinoma molecular subtypes to guide precise chemotherapy and immunotherapy
by: Jialin Meng, et al.
Published: (2023-11-01)

Identification of Potential Prognostic Biomarkers Associated With Cancerometastasis in Skin Cutaneous Melanoma
by: Yang Li, et al.
Published: (2021-07-01)

Prediction Model for Cereblon Expression in Bone Marrow Plasma Cells Based on Blood Markers in Multiple Myeloma Patients
by: Byung-Hyun Lee, et al.
Published: (2021-07-01)

FANCI serve as a prognostic biomarker correlated with immune infiltrates in skin cutaneous melanoma
by: Zhenguo Cai, et al.
Published: (2023-11-01)

Mezigdomide—A Novel Cereblon E3 Ligase Modulator under Investigation in Relapsed/Refractory Multiple Myeloma
by: Monique A. Hartley-Brown, et al.
Published: (2024-03-01)

Identification of Lactate-Related Gene Signature for Prediction of Progression and Immunotherapeutic Response in Skin Cutaneous Melanoma
by: Yalin Xie, et al.
Published: (2022-02-01)

Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury
by: Daniela Lecca, et al.
Published: (2023-03-01)

CXC Chemokines as Therapeutic Targets and Prognostic Biomarkers in Skin Cutaneous Melanoma Microenvironment
by: Xuezhi Zhou, et al.
Published: (2021-03-01)

Prognostic Value of Interleukin-32 Expression and Its Correlation with the Infiltration of Natural Killer Cells in Cutaneous Melanoma
by: Ji Young Kang, et al.
Published: (2021-10-01)

Cereblon-Recruiting PROTACs: Will New Drugs Have to Face Old Challenges?
by: Marcin Cieślak, et al.
Published: (2023-03-01)

Identification and validation of a TTN-associated immune prognostic model for skin cutaneous melanoma
by: Qirui Wang, et al.
Published: (2023-01-01)

Caspase-8 Inhibition Prevents the Cleavage and Degradation of E3 Ligase Substrate Receptor Cereblon and Potentiates Its Biological Function
by: Liang Zhou, et al.
Published: (2020-12-01)

Cutaneous metastatic adenocarcinoma
by: Mazharul Huque Khan, et al.
Published: (2010-01-01)

Pan-cancer analysis reveals the prognostic and immunologic roles of cereblon and its significance for PROTAC design
by: Si-Han Zhang, et al.
Published: (2023-06-01)

Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine
by: Tomomi Sato, et al.
Published: (2021-03-01)

Commentary: A novel signature of 23 immunity related gene pairs is prognostic of cutaneous melanoma
by: Ruihuan Shen, et al.
Published: (2023-06-01)

Rapid Progress in the Use of Immunomodulatory Drugs and Cereblon E3 Ligase Modulators in the Treatment of Multiple Myeloma
by: Grzegorz Charliński, et al.
Published: (2021-09-01)

Synergistic Cytotoxicity of Lenalidomide and Dexamethasone in Mantle Cell Lymphoma via Cereblon-dependent Targeting of the IL-6/STAT3/PI3K Axis
by: Jiexian Ma, et al.
Published: (2017-06-01)

Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon‐independent manner
by: Konstantinos Dimopoulos, et al.
Published: (2018-02-01)

ERBB1/2/3 Expression, Prognosis, and Immune Infiltration in Cutaneous Melanoma
by: Shougang Liu, et al.
Published: (2021-03-01)

System analysis based on the pyroptosis-related genes identifes GSDMD as a novel therapy target for skin cutaneous melanoma
by: Shixin Zhao, et al.
Published: (2023-11-01)

The value of cuproptosis-related differential genes in guiding prognosis and immune status in patients with skin cutaneous melanoma
by: Yuming Sun, et al.
Published: (2023-04-01)

High Expression of TIMELESS Predicts Poor Prognosis: A Potential Therapeutic Target for Skin Cutaneous Melanoma
by: Shixin Zhao, et al.
Published: (2022-05-01)

Construction of immunotherapy-related prognostic gene signature and small molecule drug prediction for cutaneous melanoma
by: Jiahua Xing, et al.
Published: (2022-07-01)

Prognostic factors for Taiwanese patients with cutaneous melanoma undergoing sentinel lymph node biopsy
by: Chiao-En Wu, et al.
Published: (2015-05-01)

Multivariable prognostic analyses of Chinese acral and cutaneous melanoma after surgical treatment for the past five years in a single cancer center
by: LIN Xinyi, SUN Wei, HU Tu, WANG Chunmeng, YAN Wangjun, LUO Zhiguo, LIU Xin, ZHONG Jingqin, ZOU Zijian, XU Yu, CHEN Yong
Published: (2022-12-01)

Clear cell adenocarcinoma of the gallbladder: A rare subtype of gallbladder carcinoma
by: Soe Htet Arker, et al.
Published: (2022-06-01)

High mortality due to cutaneous melanoma in Norway: a study of prognostic factors in a nationwide cancer registry
by: Robsahm TE, et al.
Published: (2018-05-01)

Dabrafenib for cutaneous melanoma infiltrating the vitreous: regression of metastasis and occurrence of uveitis as a secondary effect
by: Alex Fonollosa, et al.
Published: (2017-07-01)

Clear Cell Adenocarcinoma of the Female Urethra, Mimicking Cystocele
by: Yassine Ayari, et al.
Published: (2017-05-01)

Clear cell adenocarcinoma of the prostatic urethra with metachronous prostate adenocarcinoma
by: Henry Wang, et al.
Published: (2023-03-01)