Relationship between Mutations of the Epidermal Growth Factor Receptor Gene and Drug-Resistance to Gefitinib in Human Lung Cancer in vitro

Relationship between Mutations of the Epidermal Growth Factor Receptor Gene and Drug-Resistance to Gefitinib in Human Lung Cancer in vitro

Background and objective To explore cell lines' difference of drug-resistance to gefitinib and the underlying mechanism. Methods Human lung cancer cell lines of PC9, PC9/AB2, PC9/AB11, PC9/BB4 were treated in vitro , exons 18-21 of EGFR gene were sequenced and EGFR gene mRNA levels were measure...

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Bibliographic Details
Main Authors: Wei WEI, Yu FAN, Hongyu LIU, Zhihao WU, Haisu WAN, Zhiqin YAN, Ke XU, Qinghua ZHOU
Format: Article
Language:zho
Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2009-01-01
Series:Chinese Journal of Lung Cancer
Subjects:
EGFR genes
Resistance
Gefitinib
Lung neoplasms
Online Access:http://www.lungca.org/index.php?journal=01&page=article&op=view&path%5B%5D=10.3779%2Fj.issn.1009-3419.2009.01.004&path%5B%5D=197

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