The low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study.
Aims: To explore the contagiousness and new SARS-CoV-2 mutations in pediatric COVID-19.Methods: This cohort study enrolled all pediatric patients admitted to 8 hospitals in Zhejiang Province of China between 21 January and 29 February 2020, their family members and close-contact classmates. Epidemio...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-10-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S120197122100672X |
| _version_ | 1819151261289676800 |
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| author | Yinghu chen Hangping Yao Junfen Fu Qiang Shu Zhimin Chen Nanping Wu Sheng Ye Wei Wang Yan Ni Shiqiang Shang Wei Li Jishan Zheng Shibo Li Liang Hong Qi Zhang Weize Xu Junsong Chen Lingyan Fan Xiaohui Cang Jianbing Wang Xiangyun Lu Qingyi Cao |
| author_facet | Yinghu chen Hangping Yao Junfen Fu Qiang Shu Zhimin Chen Nanping Wu Sheng Ye Wei Wang Yan Ni Shiqiang Shang Wei Li Jishan Zheng Shibo Li Liang Hong Qi Zhang Weize Xu Junsong Chen Lingyan Fan Xiaohui Cang Jianbing Wang Xiangyun Lu Qingyi Cao |
| author_sort | Yinghu chen |
| collection | DOAJ |
| description | Aims: To explore the contagiousness and new SARS-CoV-2 mutations in pediatric COVID-19.Methods: This cohort study enrolled all pediatric patients admitted to 8 hospitals in Zhejiang Province of China between 21 January and 29 February 2020, their family members and close-contact classmates. Epidemiological, demographic, clinical and laboratory data were collected. Bioinformatics was used to analyze the features of SARS-CoV-2. Individuals were divided into 3 groups by the first-generation case: Groups 1 (unclear), 2 (adult), and 3 (child). The secondary attack rate (SAR) and R0 were compared among the groups.Results: The infection rate among 211 individuals was 64% (135/211). The SAR in Groups 2 and 3 was 71% (73/103) and 3% (1/30), respectively; the median R0 in Groups 2 and 3 was 2 (range: 1-8) and 0 (range: 0-1), respectively. Compared with adult cases, the SAR and R0 of pediatric cases were significantly lower (p<0.05). We obtained SARS-CoV-2 sequences from the same infant's throat and fecal samples at a two-month interval and found that the new spike protein A958D mutation detected in the stool improved thermostability theoretically.Conclusions: Children have lower ability to spread SARS-CoV-2. The new A958D mutation is a potential reason for its long residence in the intestine. |
| first_indexed | 2024-12-22T14:30:35Z |
| format | Article |
| id | doaj.art-ed6bcb39ba86491787f1c61454a0236b |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-22T14:30:35Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-ed6bcb39ba86491787f1c61454a0236b2022-12-21T18:22:46ZengElsevierInternational Journal of Infectious Diseases1201-97122021-10-01111347353The low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study.Yinghu chen0Hangping Yao1Junfen Fu2Qiang Shu3Zhimin Chen4Nanping Wu5Sheng Ye6Wei Wang7Yan Ni8Shiqiang Shang9Wei Li10Jishan Zheng11Shibo Li12Liang Hong13Qi Zhang14Weize Xu15Junsong Chen16Lingyan Fan17Xiaohui Cang18Jianbing Wang19Xiangyun Lu20Qingyi Cao21The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, ChinaThe Biosafety Tertiary Laboratory, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine. Qingchun Road 69#, Hangzhou City, Zhejiang Province, ChinaThe Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author's. Binsheng Road 3333, Hangzhou City, Zhejiang Province, China. 310052. 860571-86670006, 860571-86670013The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author's. Binsheng Road 3333, Hangzhou City, Zhejiang Province, China. 310052. 860571-86670006, 860571-86670013The Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, ChinaThe Biosafety Tertiary Laboratory, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine. Qingchun Road 69#, Hangzhou City, Zhejiang Province, ChinaThe Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, ChinaThe Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, ChinaThe Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, ChinaThe Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, ChinaThe Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, ChinaInfection Disease Department, Ningbo Women & Children's Hospital, Ningbo, ChinaInfection Disease Department, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, ChinaInfection Disease Department, Rui'an People's Hospital, Rui'an, ChinaInfection Disease Department, Affiliated Hospital of Jiaxing University, Jiaxin, ChinaThe Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, ChinaRespiratory Department, , Hangzhou, ChinaHwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, ChinaThe Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China; Institute of Genetics, and Department of Genetics, Zhejiang University School of Medicine, Hangzhou, ChinaThe Children's Hospital, National Clinical Research Center for Child Health, Children's Regional Medical Center, Zhejiang University School of Medicine, Hangzhou, China; Department of Epidemiology and Biostatistics, Zhejiang University School of Medicine, Hangzhou, ChinaThe Biosafety Tertiary Laboratory, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine. Qingchun Road 69#, Hangzhou City, Zhejiang Province, ChinaThe Biosafety Tertiary Laboratory, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases. National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine. Qingchun Road 69#, Hangzhou City, Zhejiang Province, ChinaAims: To explore the contagiousness and new SARS-CoV-2 mutations in pediatric COVID-19.Methods: This cohort study enrolled all pediatric patients admitted to 8 hospitals in Zhejiang Province of China between 21 January and 29 February 2020, their family members and close-contact classmates. Epidemiological, demographic, clinical and laboratory data were collected. Bioinformatics was used to analyze the features of SARS-CoV-2. Individuals were divided into 3 groups by the first-generation case: Groups 1 (unclear), 2 (adult), and 3 (child). The secondary attack rate (SAR) and R0 were compared among the groups.Results: The infection rate among 211 individuals was 64% (135/211). The SAR in Groups 2 and 3 was 71% (73/103) and 3% (1/30), respectively; the median R0 in Groups 2 and 3 was 2 (range: 1-8) and 0 (range: 0-1), respectively. Compared with adult cases, the SAR and R0 of pediatric cases were significantly lower (p<0.05). We obtained SARS-CoV-2 sequences from the same infant's throat and fecal samples at a two-month interval and found that the new spike protein A958D mutation detected in the stool improved thermostability theoretically.Conclusions: Children have lower ability to spread SARS-CoV-2. The new A958D mutation is a potential reason for its long residence in the intestine.http://www.sciencedirect.com/science/article/pii/S120197122100672XContagiousnessPediatricsSARS-CoV-2Evolutionary treeNew A958D mutation |
| spellingShingle | Yinghu chen Hangping Yao Junfen Fu Qiang Shu Zhimin Chen Nanping Wu Sheng Ye Wei Wang Yan Ni Shiqiang Shang Wei Li Jishan Zheng Shibo Li Liang Hong Qi Zhang Weize Xu Junsong Chen Lingyan Fan Xiaohui Cang Jianbing Wang Xiangyun Lu Qingyi Cao The low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study. International Journal of Infectious Diseases Contagiousness Pediatrics SARS-CoV-2 Evolutionary tree New A958D mutation |
| title | The low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study. |
| title_full | The low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study. |
| title_fullStr | The low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study. |
| title_full_unstemmed | The low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study. |
| title_short | The low contagiousness and new A958D mutation of SARS-CoV-2 in children: An observational cohort study. |
| title_sort | low contagiousness and new a958d mutation of sars cov 2 in children an observational cohort study |
| topic | Contagiousness Pediatrics SARS-CoV-2 Evolutionary tree New A958D mutation |
| url | http://www.sciencedirect.com/science/article/pii/S120197122100672X |
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