Disseminated Bacillus Calmette-Guérin (BCG) infections in infants with immunodeficiency
Abstract Background The Bacillus Calmette-Guérin (BCG) preparations are live-attenuated derivatives of Mycobacterium bovis. These products are used to vaccinate infants at birth, a practice that may result in a disseminated infection in those patients who have an unidentified immunodeficiency. Case...
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-017-2499-7 |
| _version_ | 1818468759062446080 |
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| author | Suleiman Al-Hammadi Ahmed R. Alsuwaidi Eman T. Alshamsi Ghassan A. Ghatasheh Abdul-Kader Souid |
| author_facet | Suleiman Al-Hammadi Ahmed R. Alsuwaidi Eman T. Alshamsi Ghassan A. Ghatasheh Abdul-Kader Souid |
| author_sort | Suleiman Al-Hammadi |
| collection | DOAJ |
| description | Abstract Background The Bacillus Calmette-Guérin (BCG) preparations are live-attenuated derivatives of Mycobacterium bovis. These products are used to vaccinate infants at birth, a practice that may result in a disseminated infection in those patients who have an unidentified immunodeficiency. Case presentation Patients who were immunized at birth with BCG and who developed a disseminated infection are reported here to emphasize the importance of taking an extensive medical history before giving the BCG vaccine. Patient 1 has a sibling who had familial hemophagocytic lymphohistiocytosis. Patient 2 has a severe immunodeficiency with profound lymphopenia. Patient 3 has a sibling who had a disseminated BCG infection. Patient 4 has two siblings with an immunodeficiency disorder; one sibling passed away in infancy and one is receiving regular immunoglobulin infusions. Patient 5 has profound lymphopenia and his brother had cytomegalovirus (CMV) pneumonitis and passed away in infancy. Conclusions These unfortunate events could have been avoided by compiling the relevant clinical and laboratory information. These cases also underscore the importance of a strict adherence to the BCG vaccine policies. Local and international registries that estimate the birth prevalence of primary immune deficiencies are needed prior to implementing universal BCG vaccination administration. |
| first_indexed | 2024-04-13T21:15:29Z |
| format | Article |
| id | doaj.art-ed6d46142d9f4a09b7d220b3b68a1793 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-04-13T21:15:29Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-ed6d46142d9f4a09b7d220b3b68a17932022-12-22T02:29:42ZengBMCBMC Research Notes1756-05002017-05-011011510.1186/s13104-017-2499-7Disseminated Bacillus Calmette-Guérin (BCG) infections in infants with immunodeficiencySuleiman Al-Hammadi0Ahmed R. Alsuwaidi1Eman T. Alshamsi2Ghassan A. Ghatasheh3Abdul-Kader Souid4Department of Pediatrics, UAE UniversityDepartment of Pediatrics, UAE UniversityDepartment of Pediatrics, Tawam HospitalDepartment of Pediatrics, Tawam HospitalDepartment of Pediatrics, UAE UniversityAbstract Background The Bacillus Calmette-Guérin (BCG) preparations are live-attenuated derivatives of Mycobacterium bovis. These products are used to vaccinate infants at birth, a practice that may result in a disseminated infection in those patients who have an unidentified immunodeficiency. Case presentation Patients who were immunized at birth with BCG and who developed a disseminated infection are reported here to emphasize the importance of taking an extensive medical history before giving the BCG vaccine. Patient 1 has a sibling who had familial hemophagocytic lymphohistiocytosis. Patient 2 has a severe immunodeficiency with profound lymphopenia. Patient 3 has a sibling who had a disseminated BCG infection. Patient 4 has two siblings with an immunodeficiency disorder; one sibling passed away in infancy and one is receiving regular immunoglobulin infusions. Patient 5 has profound lymphopenia and his brother had cytomegalovirus (CMV) pneumonitis and passed away in infancy. Conclusions These unfortunate events could have been avoided by compiling the relevant clinical and laboratory information. These cases also underscore the importance of a strict adherence to the BCG vaccine policies. Local and international registries that estimate the birth prevalence of primary immune deficiencies are needed prior to implementing universal BCG vaccination administration.http://link.springer.com/article/10.1186/s13104-017-2499-7VaccinesBCGMycobacterium bovisDanish-SSI 1331 strainImmunodeficiencyNewborns |
| spellingShingle | Suleiman Al-Hammadi Ahmed R. Alsuwaidi Eman T. Alshamsi Ghassan A. Ghatasheh Abdul-Kader Souid Disseminated Bacillus Calmette-Guérin (BCG) infections in infants with immunodeficiency BMC Research Notes Vaccines BCG Mycobacterium bovis Danish-SSI 1331 strain Immunodeficiency Newborns |
| title | Disseminated Bacillus Calmette-Guérin (BCG) infections in infants with immunodeficiency |
| title_full | Disseminated Bacillus Calmette-Guérin (BCG) infections in infants with immunodeficiency |
| title_fullStr | Disseminated Bacillus Calmette-Guérin (BCG) infections in infants with immunodeficiency |
| title_full_unstemmed | Disseminated Bacillus Calmette-Guérin (BCG) infections in infants with immunodeficiency |
| title_short | Disseminated Bacillus Calmette-Guérin (BCG) infections in infants with immunodeficiency |
| title_sort | disseminated bacillus calmette guerin bcg infections in infants with immunodeficiency |
| topic | Vaccines BCG Mycobacterium bovis Danish-SSI 1331 strain Immunodeficiency Newborns |
| url | http://link.springer.com/article/10.1186/s13104-017-2499-7 |
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