Pharmacological Functions, Synthesis, and Delivery Progress for Collagen as Biodrug and Biomaterial
Collagen has been widely applied as a functional biomaterial in regulating tissue regeneration and drug delivery by participating in cell proliferation, differentiation, migration, intercellular signal transmission, tissue formation, and blood coagulation. However, traditional extraction of collagen...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/5/1443 |
| _version_ | 1797598738551668736 |
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| author | Nan Zhou Yu-Da Liu Yue Zhang Ting-Wei Gu Li-Hua Peng |
| author_facet | Nan Zhou Yu-Da Liu Yue Zhang Ting-Wei Gu Li-Hua Peng |
| author_sort | Nan Zhou |
| collection | DOAJ |
| description | Collagen has been widely applied as a functional biomaterial in regulating tissue regeneration and drug delivery by participating in cell proliferation, differentiation, migration, intercellular signal transmission, tissue formation, and blood coagulation. However, traditional extraction of collagen from animals potentially induces immunogenicity and requires complicated material treatment and purification steps. Although semi-synthesis strategies such as utilizing recombinant <i>E. coli</i> or <i>yeast</i> expression systems have been explored as alternative methods, the influence of unwanted by-products, foreign substances, and immature synthetic processes have limited its industrial production and clinical applications. Meanwhile, macromolecule collagen products encounter a bottleneck in delivery and absorption by conventional oral and injection vehicles, which promotes the studies of transdermal and topical delivery strategies and implant methods. This review illustrates the physiological and therapeutic effects, synthesis strategies, and delivery technologies of collagen to provide a reference and outlook for the research and development of collagen as a biodrug and biomaterial. |
| first_indexed | 2024-03-11T03:24:53Z |
| format | Article |
| id | doaj.art-ed6e94e277634d5e8fbbd7f8f145be4d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T03:24:53Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-ed6e94e277634d5e8fbbd7f8f145be4d2023-11-18T02:51:39ZengMDPI AGPharmaceutics1999-49232023-05-01155144310.3390/pharmaceutics15051443Pharmacological Functions, Synthesis, and Delivery Progress for Collagen as Biodrug and BiomaterialNan Zhou0Yu-Da Liu1Yue Zhang2Ting-Wei Gu3Li-Hua Peng4College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, ChinaCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, ChinaCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, ChinaCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, ChinaCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, ChinaCollagen has been widely applied as a functional biomaterial in regulating tissue regeneration and drug delivery by participating in cell proliferation, differentiation, migration, intercellular signal transmission, tissue formation, and blood coagulation. However, traditional extraction of collagen from animals potentially induces immunogenicity and requires complicated material treatment and purification steps. Although semi-synthesis strategies such as utilizing recombinant <i>E. coli</i> or <i>yeast</i> expression systems have been explored as alternative methods, the influence of unwanted by-products, foreign substances, and immature synthetic processes have limited its industrial production and clinical applications. Meanwhile, macromolecule collagen products encounter a bottleneck in delivery and absorption by conventional oral and injection vehicles, which promotes the studies of transdermal and topical delivery strategies and implant methods. This review illustrates the physiological and therapeutic effects, synthesis strategies, and delivery technologies of collagen to provide a reference and outlook for the research and development of collagen as a biodrug and biomaterial.https://www.mdpi.com/1999-4923/15/5/1443collagenpharmacological functionsbiosynthesisdelivery technologies |
| spellingShingle | Nan Zhou Yu-Da Liu Yue Zhang Ting-Wei Gu Li-Hua Peng Pharmacological Functions, Synthesis, and Delivery Progress for Collagen as Biodrug and Biomaterial Pharmaceutics collagen pharmacological functions biosynthesis delivery technologies |
| title | Pharmacological Functions, Synthesis, and Delivery Progress for Collagen as Biodrug and Biomaterial |
| title_full | Pharmacological Functions, Synthesis, and Delivery Progress for Collagen as Biodrug and Biomaterial |
| title_fullStr | Pharmacological Functions, Synthesis, and Delivery Progress for Collagen as Biodrug and Biomaterial |
| title_full_unstemmed | Pharmacological Functions, Synthesis, and Delivery Progress for Collagen as Biodrug and Biomaterial |
| title_short | Pharmacological Functions, Synthesis, and Delivery Progress for Collagen as Biodrug and Biomaterial |
| title_sort | pharmacological functions synthesis and delivery progress for collagen as biodrug and biomaterial |
| topic | collagen pharmacological functions biosynthesis delivery technologies |
| url | https://www.mdpi.com/1999-4923/15/5/1443 |
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