Platycodin D sensitizes KRAS-mutant colorectal cancer cells to cetuximab by inhibiting the PI3K/Akt signaling pathway

Platycodin D sensitizes KRAS-mutant colorectal cancer cells to cetuximab by inhibiting the PI3K/Akt signaling pathway

Cetuximab is a monoclonal antibody against epidermal growth factor receptor that blocks downstream signaling pathways of receptor tyrosine kinases, including Ras/Raf/MAPK and PI3K/Akt, thereby inhibiting tumor cell proliferation and inducing cancer cell apoptosis. Owing to KRAS mutations, the effect...

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Bibliographic Details
Main Authors: Yanfei Liu, Shifeng Tian, Ben Yi, Zhiqiang Feng, Tianhao Chu, Jun Liu, Chunze Zhang, Shiwu Zhang, Yijia Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
Akt
cetuximab
colorectal cancer
platycodin D
resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1046143/full

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