Metabolomics detects clinically silent neuroinflammatory lesions earlier than neurofilament-light chain in a focal multiple sclerosis animal model

Metabolomics detects clinically silent neuroinflammatory lesions earlier than neurofilament-light chain in a focal multiple sclerosis animal model

Abstract Background Despite widespread searches, there are currently no validated biofluid markers for the detection of subclinical neuroinflammation in multiple sclerosis (MS). The dynamic nature of human metabolism in response to changes in homeostasis, as measured by metabolomics, may allow early...

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Bibliographic Details
Main Authors: Tianrong Yeo, Halwan Bayuangga, Marcus Augusto-Oliveira, Megan Sealey, Timothy D. W. Claridge, Rachel Tanner, David Leppert, Jacqueline Palace, Jens Kuhle, Fay Probert, Daniel C. Anthony
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
Metabolomics
Neurofilament-light
Delayed-type hypersensitivity
Biomarker
Blood
Online Access:https://doi.org/10.1186/s12974-022-02614-8

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